Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
TN3468 | Atractylochromene
化合物 TN3468
|
203443-33-8 | 98% |
|
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colo... | ||||
TN1694 | Gliotoxin
胶霉毒素
|
67-99-2 | 98% |
|
Gliotoxin 是一种次生代谢产物,由A. fumigatus 分泌,可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性,从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度,调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞... | ||||
TN3525 | Boehmenan
化合物 TN3525
|
57296-22-7 | 98% |
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ... | ||||
TN3319 | 9-Hydroxycanthin-6-one
化合物 TN3319
|
138544-91-9 | 98% |
|
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ... | ||||
TMA1743 | Ergosterol peroxide
过氧麦角甾醇
|
2061-64-5 | 98% |
|
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox... | ||||
TN2995 | 4,10-Aromadendranediol
化合物 TN2995
|
70051-38-6 | 98% |
|
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm... | ||||
TN2775 | 2-Methoxystypandrone
化合物 TN2775
|
85122-21-0 | 98% |
|
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm... | ||||
T12537 | β-catenin/CBP-IN-1
化合物 T12537
|
1198780-38-9 | 98% |
|
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin | ||||
TP1565L | Foxy-5 acetate
化合物Foxy-5 acetate
|
TP1565L | 98% |
|
Foxy-5 acetate 是 Wnt 5A 的激动剂,Wnt 5A 是 Wnt 家族的非经典成员。 Foxy-5 acetate 损害上皮癌细胞的迁移和侵袭,触发细胞溶质游离钙信号传导,而不影响 β-连环蛋白活化。 | ||||
TN4046 | Excisanin A
化合物 TN4046
|
78536-37-5 | 98% |
|
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote... | ||||
T35556 | GSK-3β inhibitor 8
GSK-3β抑制剂8
|
1139875-74-3 | 98% |
|
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII)是具有有效和选择性的 GSK-3β 抑制剂 ,IC50值为 64 nM。GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物,负调控 Wnt 信号通路,刺激 β 细胞增殖。 | ||||
T13078 | Tankyrase-IN-2
化合物 T13078
|
1588870-36-3 | 98% |
|
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively | ||||
T5342 | IWP-O1
化合物IWP-O1
|
2074607-48-8 | 99.98% |
|
IWP-O1 是 Porcn 抑制剂,在 L-Wnt-STF 细胞中的 EC50值为 80 pM。它能够抑制 Wnt 蛋白分泌,可以抑制 HeLa 细胞中 Dvl2/3 和 LRP6 磷酸化。 | ||||
T6673 | SKI II
化合物SKI II
|
312636-16-1 | 99.97% |
|
SKI II (SphK-I2) 是一种口服有效的合成鞘氨醇激酶 (SK)抑制剂,抑制 SK1 和 SK2,IC50值分别为 78 μM 和 45 μM。它通过诱导溶酶体/蛋白酶体降解,不可逆地抑制SK1。 | ||||
T0470 | Nefopam hydrochloride
盐酸奈福泮
|
23327-57-3 | 99.97% |
|
Nefopam hydrochloride (Nefopam HCl) 作用于体外和体内间充质细胞β-连环蛋白水平,是一种中枢性但非阿片类缓解中度和重度疼痛。 | ||||
T7830 | Windorphen
3-氯-2,3-双(4-甲氧苯基)丙烯醛
|
19881-70-0 | 99.96% |
|
Windorphen 是一种 Wnt 抑制剂,可选择性地消除 Wnt 信号传导。 | ||||
T17256 | Wnt pathway activator 1
化合物Wnt pathway activator 1
|
1360540-81-3 | 99.94% |
|
Wnt pathway activator 1 是Wnt 激活剂(EC50=28-29 nM)。 | ||||
T6768 | AZ6102
化合物AZ6102
|
1645286-75-4 | 99.91% |
|
AZ6102 是TNKS1和TNKS2双重抑制剂,IC50值分别为 3 和 1 nM,选择性是对 PARP 家族其他蛋白的 100 多倍,对 PARP1、PARP2 和 PARP6 的IC50值分别为 2.0、0.5 和大于 3 μM。 | ||||
T24076 | FzM1
化合物FzM1
|
1680196-54-6 | 99.89% |
|
FzM1 是卷曲蛋白受体 FZD4 的负变构调节剂 (NAM)。 FzM1减少 WNT5A 依赖的 WNT 反应元件 (WRE) 活性 (log EC50inh=-6.2)。 FzM1 与位于 FZD4 细胞内环 3 (ICL3) 的变构结合位点结合并改变受体的构象,从而抑制 WNT/β-连环蛋白级联反应。 | ||||
T9182 | NRX-252262
化合物NRX-252262
|
2438637-61-5 | 99.87% |
|
NRX-252262 是 β-Catenin 与同源 E3 ligaseSCFβ-TrCP 的相互作用增强剂,能够诱导 β-catenin 的降解,其 EC50=3.8 nM。 |