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Wnt/beta-catenin

Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.
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Cat. No. Product Name CAS No. Purity Chemical Structure
TQ0215 Salinomycin sodium salt
盐霉素钠
55721-31-8 98%
Salinomycin sodium salt (Sodium salinomycin) 是钾离子载体抗生素,是作用于 Wnt/Fzd/LRP 复合物的Wnt/β-catenin 信号传导抑制剂,能阻断 Wnt 诱导的 LRP6 磷酸化,导致 LRP6 蛋白降解。它选择性抑制人肿瘤干细胞。
TN3468 Atractylochromene
化合物 TN3468
203443-33-8 98%
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colo...
TN1694 Gliotoxin
胶霉毒素
67-99-2 98%
Gliotoxin 是一种次生代谢产物,由A. fumigatus 分泌,可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性,从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度,调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞...
TN3525 Boehmenan
化合物 TN3525
57296-22-7 98%
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN3319 9-Hydroxycanthin-6-one
化合物 TN3319
138544-91-9 98%
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
TMA1743 Ergosterol peroxide
过氧麦角甾醇
2061-64-5 98%
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
TN2995 4,10-Aromadendranediol
化合物 TN2995
70051-38-6 98%
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
TN2775 2-Methoxystypandrone
化合物 TN2775
85122-21-0 98%
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
T12537 β-catenin/CBP-IN-1
化合物 T12537
1198780-38-9 98%
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
TP1565L Foxy-5 acetate
化合物Foxy-5 acetate
TP1565L 98%
Foxy-5 acetate 是 Wnt 5A 的激动剂,Wnt 5A 是 Wnt 家族的非经典成员。 Foxy-5 acetate 损害上皮癌细胞的迁移和侵袭,触发细胞溶质游离钙信号传导,而不影响 β-连环蛋白活化。
TN4046 Excisanin A
化合物 TN4046
78536-37-5 98%
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T35556 GSK-3β inhibitor 8
GSK-3β抑制剂8
1139875-74-3 98%
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII)是具有有效和选择性的 GSK-3β 抑制剂 ,IC50值为 64 nM。GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物,负调控 Wnt 信号通路,刺激 β 细胞增殖。
T13078 Tankyrase-IN-2
化合物 T13078
1588870-36-3 98%
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
T5342 IWP-O1
化合物IWP-O1
2074607-48-8 99.98%
IWP-O1 是 Porcn 抑制剂,在 L-Wnt-STF 细胞中的 EC50值为 80 pM。它能够抑制 Wnt 蛋白分泌,可以抑制 HeLa 细胞中 Dvl2/3 和 LRP6 磷酸化。
T6673 SKI II
化合物SKI II
312636-16-1 99.97%
SKI II (SphK-I2) 是一种口服有效的合成鞘氨醇激酶 (SK)抑制剂,抑制 SK1 和 SK2,IC50值分别为 78 μM 和 45 μM。它通过诱导溶酶体/蛋白酶体降解,不可逆地抑制SK1。
T0470 Nefopam hydrochloride
盐酸奈福泮
23327-57-3 99.97%
Nefopam hydrochloride (Nefopam HCl) 作用于体外和体内间充质细胞β-连环蛋白水平,是一种中枢性但非阿片类缓解中度和重度疼痛。
T7830 Windorphen
3-氯-2,3-双(4-甲氧苯基)丙烯醛
19881-70-0 99.96%
Windorphen 是一种 Wnt 抑制剂,可选择性地消除 Wnt 信号传导。
T17256 Wnt pathway activator 1
化合物Wnt pathway activator 1
1360540-81-3 99.94%
Wnt pathway activator 1 是Wnt 激活剂(EC50=28-29 nM),摘自专利 WO2012024404A1,compound 1。
T6768 AZ6102
化合物AZ6102
1645286-75-4 99.91%
AZ6102 是TNKS1和TNKS2双重抑制剂,IC50值分别为 3 和 1 nM,选择性是对 PARP 家族其他蛋白的 100 多倍,对 PARP1、PARP2 和 PARP6 的IC50值分别为 2.0、0.5 和大于 3 μM。
TP1263 Fz7-21
化合物Fz7-21
2247635-23-8 99.8%
Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) 是一种 Frizzled 7 (FZD 7) 受体的肽抑制剂,能够选择性的与FZD7 CRD 亚类结合。它还阻断了WNT3A 介导的β-catenin 在小鼠L 细胞中的稳定作用。它对外源性WNT3A 刺激和转染WNT3A 或WNT1的HEK293细胞Wn...
Salinomycin sodium salt
TQ0215
Salinomycin sodium salt (Sodium salinomycin) 是钾离子载体抗生素,是作用于 Wnt/Fzd/LRP 复合物的Wnt/β-catenin 信号传导抑制剂,能阻断 Wnt 诱导的 LRP6 磷酸化,导致 LRP6 蛋白降解。它选择性抑制人肿瘤干细胞。
Atractylochromene
TN3468
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colo...
Gliotoxin
TN1694
Gliotoxin 是一种次生代谢产物,由A. fumigatus 分泌,可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性,从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度,调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
9-Hydroxycanthin-6-one
TN3319
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
Ergosterol peroxide
TMA1743
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
4,10-Aromadendranediol
TN2995
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
2-Methoxystypandrone
TN2775
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
β-catenin/CBP-IN-1
T12537
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
Foxy-5 acetate
TP1565L
Foxy-5 acetate 是 Wnt 5A 的激动剂,Wnt 5A 是 Wnt 家族的非经典成员。 Foxy-5 acetate 损害上皮癌细胞的迁移和侵袭,触发细胞溶质游离钙信号传导,而不影响 β-连环蛋白活化。
Excisanin A
TN4046
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
GSK-3β inhibitor 8
T35556
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII)是具有有效和选择性的 GSK-3β 抑制剂 ,IC50值为 64 nM。GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物,负调控 Wnt 信号通路,刺激 β 细胞增殖。
Tankyrase-IN-2
T13078
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
IWP-O1
T5342
IWP-O1 是 Porcn 抑制剂,在 L-Wnt-STF 细胞中的 EC50值为 80 pM。它能够抑制 Wnt 蛋白分泌,可以抑制 HeLa 细胞中 Dvl2/3 和 LRP6 磷酸化。
SKI II
T6673
SKI II (SphK-I2) 是一种口服有效的合成鞘氨醇激酶 (SK)抑制剂,抑制 SK1 和 SK2,IC50值分别为 78 μM 和 45 μM。它通过诱导溶酶体/蛋白酶体降解,不可逆地抑制SK1。
Nefopam hydrochloride
T0470
Nefopam hydrochloride (Nefopam HCl) 作用于体外和体内间充质细胞β-连环蛋白水平,是一种中枢性但非阿片类缓解中度和重度疼痛。
Windorphen
T7830
Windorphen 是一种 Wnt 抑制剂,可选择性地消除 Wnt 信号传导。
Wnt pathway activator 1
T17256
Wnt pathway activator 1 是Wnt 激活剂(EC50=28-29 nM),摘自专利 WO2012024404A1,compound 1。
AZ6102
T6768
AZ6102 是TNKS1和TNKS2双重抑制剂,IC50值分别为 3 和 1 nM,选择性是对 PARP 家族其他蛋白的 100 多倍,对 PARP1、PARP2 和 PARP6 的IC50值分别为 2.0、0.5 和大于 3 μM。
Fz7-21
TP1263
Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) 是一种 Frizzled 7 (FZD 7) 受体的肽抑制剂,能够选择性的与FZD7 CRD 亚类结合。它还阻断了WNT3A 介导的β-catenin 在小鼠L 细胞中的稳定作用。它对外源性WNT3A 刺激和转染WNT3A 或WNT1的HEK293细胞Wn...
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