k-ras

KRas(G12C) inhibitor 6 是一种变构的，选择性的 K-Ras(G12C)抑制剂。

K-Ras(G12C) inhibitor 9 是致癌 K-Ras(G12C) 的变构抑制剂。

K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。

K-Ras-IN-1 是K-Ras 抑制剂。K-Ras-IN-1 能与 K-Ras (WT)、K-Ras (G12D)、K-Ras (G12V) 和 H-Ras 结合。它对胰腺癌、结肠癌和肺癌的具潜在的研究价值。

K-Ras(G12C) inhibitor 12是一种K-Ras(G12C)抑制剂，作用于H1792细胞，EC50为0.32 μM。

K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.

Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers.K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.

PROTAC K-Ras Degrader-1 是一种基于 Cereblon E3 配体的 PROTAC 降解剂，可降解 K-Ras。

K-Ras ligand-Linker Conjugate 1 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, facilitating the recruitment of E3 ligases VHL, CRBN, MDM2, and IAP. It can be utilized in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound that consists of a ligand for K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that demonstrates a degradation efficacy of ≥70% in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 4 is a chemical compound that combines a ligand for K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The compound has the potential to be used in the synthesis of PROTAC K-Ras Degrader-1, a powerful degrader of K-Ras that has been shown to exhibit a degradation efficacy of ≥70% in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 5 is a chemical compound that combines a ligand for the K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The K-Ras ligand-Linker Conjugate 5 plays a crucial role in the synthesis of PROTAC K-Ras Degrader-1, a highly potent K-Ras degrader. In SW1573 cells, this degrader exhibits an impressive degradation efficacy of ≥70% [1].

BMS-214662是一种选择性的 farnesyl transferase 抑制剂，具有抗肿瘤活性，可用于研究胰腺癌、头颈癌和肺癌。

CP-609754 是高效的、可逆的法尼基转移酶抑制剂，对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng mL 和 46 ng mL。CP-609754有潜在的抗癌作用。

Oncrasin 1 是一种有效的抗癌抑制剂，可在低或亚微摩尔浓度下杀死具有 K-Ras 突变的各种人类肺癌细胞。

K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.

K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker. This compound is capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC K-Ras Degrader-1, which is a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 6 是一种结合 K-Ras 招募片段配体和PROTAC连接子的化合物,可募集 E3 连接酶,合成 PROTAC K-Ras Degrader-1.

PROTAC K-Ras Degrader-3（化合物 40）为特定靶向K-Ras的PROTAC降解剂，其在SW620 KRAS G12D 细胞上体现出极高效力，DC50 值不超过1 nM，同时对SW620 3D 细胞生长的GI50 值亦不高于10 nM。该化合物常用于癌症领域的研究工作。

PROTAC K-Ras degrader-2 (compound 48) 是一种广谱KRAS突变体PROTAC降解剂，对KRAS G12V RAF1的IC50≤200 nM。该化合物可以降解SW620 KRAS G12D，DC50≤200 nM，并抑制SW620 3D细胞扩增，其IC50≤20 nM。

Pan-KRAS degrader 4 (compound 69) 作为一种基于cereblon的PROTACKRAS降解剂，展现出抗癌效能，其DC50 值低于 100 nM。

Pan-KRAS degrader 5 (compound 102) 作为基于cereblon的PROTACKRAS降解剂，展现出显著的抗癌活性，其DC50 值低于100 nM。

BI-2493 是高度选择的泛 KRAS 抑制剂，是 BI-2865 的结构类似物。BI-2493 具有抗肿瘤活性，可抑制肿瘤细胞生长，可用于癌症疾病的研究。

BI-2865 是一种非共价的泛-KRAS 抑制剂。BI-2865 可与 KRAS WT、G12C、G12D、G12V 和 G13D 突变体结合，KD 值 分别为 6.9、4.5、32、26、4.3 nM。BI-2865在对 表达 KRAS G12C、G12D 或 G12V 突变体的 BaF3 细胞实验的过程中显示出抗增殖活性 ，平均 IC50值大约为 140 nM。[1]