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**HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled**

产品编号 TMPK-01435

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

**HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled**

产品编号 TMPK-01435

规格	价格	库存	数量
100 μg	¥ 18,900	5日内发货
1 mg	¥ 126,000	5日内发货

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产品信息

生物活性	Immobilized HLA-A11:01&B2M&KRAS G12D TCR at 1μg/ml (100μl/well) on the plate. Dose response curve for PE Labeled Human HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer, His Tag with the EC50 of 0.11μg/ml determined by ELISA.
产品描述	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
种属	Human
表达系统	HEK293 Cells
标签	C-His-Avi
蛋白编号	NP_002107.3(HLA-A*03:01)&P61769(B2M)&VVVGAVGVGK
别名	RASK2,RALD,NS3,NS,MHC,K-RAS4B,K-RAS4A,K-RAS2B,K-RAS2A,KRAS2,KRAS1,K-Ras 2,KRAS,KI-RAS,GTPase Kras,C-K-RAS,CFC2
蛋白构建	Gly25-Thr305(HLA-A03:01), Ile21-Met119(B2M) and VVVGAVGVGK peptide. PE-Labeled Human KRAS G12V (HLA-A03:01) Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin.
内毒素	< 1 EU/μg by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, 0.2% BSA (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.