Name: HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein, Human, MHC (His & Avi)
Brand: TargetMol
SKU: TMPK-01507
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 1,290

6-8日内发货

10 μg

¥ 2,180

6-8日内发货

20 μg

¥ 3,690

5日内发货

50 μg

¥ 7,430

5日内发货

100 μg

¥ 12,600

5日内发货

生物活性

产品描述	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
生物活性	Immobilized HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) TCR at 1μg/ml (100μl/well) on the plate. Dose response curve for Human HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer, His Tag with the EC50 of 51.5ng/ml determined by ELISA.
研究背景	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
种属	Human
表达系统	HEK293 Cells
标签	C-His-Avi
蛋白编号	AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGADGVGK
蛋白构建	Gly25-Thr305(HLA-A*11:01),Ile21-Met119(B2M) and VVVGADGVGK peptide. Tetramer is assembled by biotinylated monomer and streptavidin.
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名	RASK2, RALD, NS3, NS, MHC, K-RAS4B, K-RAS4A, K-RAS2B, K-RAS2A, KRAS2, KRAS1, K-Ras 2, KRAS, KI-RAS, GTPase Kras, C-K-RAS, CFC2
内毒素	< 1 EU/μg by the LAL method.

化学信息

分子量	The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.

储存&溶解度

运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein, Human, MHC (His & Avi)

**HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein, Human, MHC (His & Avi)**

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