adp

Prasugrel (CS-747) 是一种噻吩吡啶和前药，是一种可口服的 P2Y12受体拮抗剂，抑制 ADP 诱导的血小板聚集，用于预防急性冠状动脉综合征患者的血栓形成、不稳定型心绞痛和心肌梗塞，以及接受经皮冠状动脉介入治疗的患者。

Adenosine 5'-diphosphate (ADP) 属于天然核苷酸，由 ATP 去磷酸化得到。Adenosine 5'-diphosphate 对细胞代谢至关重要，还可诱导血小板聚集。

Tirofiban（MK383） hydrochloride monohydrate是一种非肽类糖蛋白IIb/IIIa 的拮抗剂。

Limaprost (17α,20-dimethyl-δ2-PGE1) 是PGE1类似物，也是口服具有活性的血管舒张剂。它能够增加血流量以及减少血小板聚集。它具有抗心绞痛的功能，可用于疼痛的缓解，以及用于研究缺血性症状。

Ticlopidine (PCR 5332) 是抗血栓前药。它是CYP2C19人肝细胞色素的抑制剂，抑制 CYP2C9 及 CYP3A4。他是变构CD39的非竞争性抑制剂，能够阻断 NTPDase 同工酶，对NTPDase2和NTPDase3的IC50分别为 170 µM 和 149 µM。

Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release

2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) 是 Adenosine 5'-diphosphate（ADP）的衍生物，能够诱导血小板聚集并抑制腺苷酸环化酶 (adenylate cyclase) 的活性。该化合物抑制 Mortalin 的核苷酸结合域 (NBD)，其 Ki 值为 45.05 μM。

ADP-β-S (trisodium) 是一种ADP类似物及部分激动剂。ADP-β-S (trisodium) 能促使人类血小板聚集，同时抑制PGE1刺激的腺苷酸环化酶活性。

2-Fluoro-ADP is a bioactive chemical.

ADP-2341 is a soluble analog of FiVe1.

ADP-Ribosylarginine can regulate cell proliferation and tumorigenesis.

ADP-Glucose (ADPG) is an immediate precursor used in the biosynthesis, by glucose addition, of storage polysaccharides in plants, green algae, and cyanobacteria, as well as structural polysaccharides in certain bacteria.[1],[2] It is used by amylose synthases or starch synthases in plastids in the production of amylose, amylopectins, starch, and other polysaccharides. ADPG is normally generated within plastids, although it can be biosynthesized in the cytoplasm of certain grasses and imported into plastids by a membrane-bound transporter.[3]

Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8] In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with isoproterenol , and treatment with this metabolite at 100 μM under heat stress conditions induces the release of oxytocin from the mouse hypothalamus.[9],[4]

Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-mediated release from the endoplasmic reticulum, while also facilitating extracellular influx through the opening of TRPM2 channels [1][2][3].

Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD+ by cADP-ribose synthases, including CD38. cADP-Ribose appears to activate calcium channels in intracellular membranes, which in turn activate ryanodine receptors. 8-bromo-cADP-Ribose is a stable, cell-permeable analog that blocks calcium release evoked by cADP-ribose in sea urchin egg homogenates with an IC50 value of 1.7 μM. It is commonly used to investigate intracellular signaling through cADP-ribose in isolated cells and tissues.

8-Azido-ADP (disodium) 是一种线粒体腺嘌呤核苷酸易位的共价结合抑制剂，对ADP 诱导的线粒体呼吸的 4 到 3 正常转变表现出抑制作用。在光依赖反应中，8-Azido-ADP (disodium) 不可逆的抑制腺嘌呤核苷酸交换。

2′-OMe-ADP 是用于寡核苷酸合成的核苷酸类似物。

8-Br-7-CH-cADPR disodium (7-Deaza-8-bromo-cADPR) 是一种有效的cADPR拮抗剂，该化合物能够部分抑制sTIR二聚化引起的钙浓度升高，并显著降低紫杉醇诱导的轴突变性。

2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) 是一种高效的嘌呤能 (P2Y) 受体激动剂，对人 P2Y13、小鼠 P2Y13 和人 P2Y12 的EC50分别为19、6.2 和 5 nM，对人 P2Y1 和大鼠 P2Y6 的 pEC50分别是8.29 和 5.75。2-MeSADP 能诱导血小板聚集和形态改变，并能抑制前列腺素 E1 介导的血小板内环腺苷酸的积累。

pNP-ADPr is a colorimetric substrate employed in the first continuous activity assays for Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3). Its utilization facilitates research on poly(ADP-ribose) polymerase (PARP) enzymes.

8-Br-7-CH-cADPR (7-Deaza-8-bromo-cADPR) 是一种cADPR有效拮抗剂。该化合物能部分抑制sTIR二聚化引发的钙离子升高。此外，8-Br-7-CH-cADPR 对于降低紫杉醇诱导的轴突变性也有显著效果。

8-Br-cADPR为cADPR的高效拮抗剂,能有效减轻肾损伤并降低caspase-3与TRPM2的表达水平.

ADP-Specificglucokinase，一种嗜热古细菌中表达的 ADP 特异性葡萄糖激酶，主要功能是催化葡萄糖转化为葡萄糖-6-磷酸，从而推动糖酵解过程。此外，ADP-Specificglucokinase 在免疫调节中也扮演角色，能激活 T 细胞并增强巨噬细胞的吞噬能力。该酶在研究代谢性疾病、神经系统疾病及肿瘤方面具有潜在应用价值。

Olaparib (KU0059436) 是 PARP1/PARP2 的小分子抑制剂 (IC50=5/1 nM)，对 PARP tankyrase-1 的抑制活性较弱 (IC50=1.5 μM)，具有选择性和口服活性。Olaparib 具有自噬和线粒体自噬激活活性。