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UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)

产品编号 TMPY-04480

CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid biosynthesis.

UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)

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产品编号 TMPY-04480

规格	价格	库存
5 μg	¥ 472	6-8日内发货
10 μg	¥ 772	6-8日内发货
20 μg	¥ 1,270	5日内发货
50 μg	¥ 2,930	5日内发货

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产品信息

生物活性	Kinase activity untested
产品描述	CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid biosynthesis.
种属	Human
表达系统	Baculovirus Insect Cells
标签	N-His
蛋白编号	P30085
别名	UMPK,UMP-CMPK,UMK,cytidine monophosphate (UMP-CMP) kinase 1, cytosolic,CMPK,CMK,CK
蛋白构建	A DNA sequence encoding the human CMPK1 (P30085) (Met1-Gly196) was fused with a polyhistide tag at the N-terminus. Predicted N terminal: His
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	24.5 kDa (predicted); 27 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Solution
缓冲液	Supplied as sterile 20 mM Tris, 500 mM Nacl, pH 7.4, 10% glycerol.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
研究背景	CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid biosynthesis.