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Anti-DUOX2 Polyclonal Antibody

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货号 TMAB-00575

别名 Thyroid oxidase 2, THOX2, P138 TOX, p138 thyroid oxidase, NOXEF2, NADPH thyroid oxidase 2, NADPH oxidase/peroxidase DUOX2, NADH/NADPH thyroid oxidase p138-tox, Long NOX 2, LNOX2, Large NOX 2, Dual oxidase2, Dual oxidase 2

Anti-DUOX2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DUOX2。Anti-DUOX2 Polyclonal Antibody 可用于 ELISA,ICC/IF,IF,IHC-Fr,IHC-P。

Anti-DUOX2 Polyclonal Antibody

Anti-DUOX2 Polyclonal Antibody

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货号 TMAB-00575 别名 Thyroid oxidase 2, THOX2, P138 TOX, p138 thyroid oxidase, NOXEF2, NADPH thyroid oxidase 2, NADPH oxidase/peroxidase DUOX2, NADH/NADPH thyroid oxidase p138-tox, Long NOX 2, LNOX2, Large NOX 2, Dual oxidase2, Dual oxidase 2

Anti-DUOX2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DUOX2。Anti-DUOX2 Polyclonal Antibody 可用于 ELISA,ICC/IF,IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-DUOX2 Polyclonal Antibody is a Rabbit antibody targeting DUOX2. Anti-DUOX2 Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P.
别名Thyroid oxidase 2, THOX2, P138 TOX, p138 thyroid oxidase, NOXEF2, NADPH thyroid oxidase 2, NADPH oxidase/peroxidase DUOX2, NADH/NADPH thyroid oxidase p138-tox, Long NOX 2, LNOX2, Large NOX 2, Dual oxidase2, Dual oxidase 2
Ig Type
IgG
反应种属
(predicted:Human,Mouse,Rat,Dog)
应用ELISAICC/IFIFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Apical cell membrane. Localizes to the apical membrane of epithelial cells.
组织特异性Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景Dual oxidase 2 (DUOX2), also designated NADPH thyroid oxidase 2, p138 thyroid oxidase or large NOX2, localizes to the apical membrane of epithelial cells. DUOX1, also designated NADPH thyroid oxidase or large NOX1, and DUOX2 are multi-pass membrane proteins predominantly expressed in thyrocytes, tracheal surface epithelial cells as well as thyroid, colon, duodenum, trachea and bronchium. DUOX1 and DUOX2 generate hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. In mucosa, DUOX proteins are involved in thyroid hormone biosynthesis and lactoperoxidase-mediated antimicrobial defense. Defects in the gene encoding for DUOX2 cause congenital hypothyroidism (CH), a disorder characterized by a defect in hydrogen peroxide production in the thyroid gland.
抗原信息
免疫原
KLH conjugated synthetic peptide: human DUOX2
抗原种属
Human
基因名称
DUOX2
基因ID
50506
蛋白名称
Dual oxidase 2
Uniprot ID
Q9NRD8
研究领域
Thyroid axis
功能
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
化学信息
分子量Theoretical: 173 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

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