首页工具

登录

搜索结果

Search Results for " kras "

203

抑制剂 & 化合物

1

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T78212	KRAS G12D inhibitor 18 KRAS G12D IN 18	Others	Others
	KRAS G12D inhibitor 18 为一种有效的 KRAS G12D 抑制剂，具有潜在的抗肿瘤和抑制肿瘤细胞增殖的活性，可用于研究胰腺癌。
T8756	KRAS inhibitor-9 DUN09716	Apoptosis; Ras	Apoptosis; GPCR/G Protein; MAPK
	KRAS inhibitor-9 (DUN09716) 是一种 KRAS 抑制剂，阻止 GTP-KRAS 的形成和 KRAS 下游激活。它以中等的结合亲和力与 KRAS G12D、KRAS G12C 和 KRAS Q61H 蛋白结合，选择性抑制具有 KRAS 突变的 NSC-LC 细胞的增殖。它可导致 G2/M 细胞周期停滞并诱导凋亡。
T40286	KRAS G12C inhibitor 19	Ras	GPCR/G Protein; MAPK
	KRAS G12C inhibitor 19 是一种有效的 KRAS G12C 抑制剂，在细胞实验中显示出抗肿瘤活性，科抑制肿瘤生长。
T38936	KRAS G13D peptide, 25 mer KRAS G13D peptide, 25 mer
	KRAS G13D peptide, a 25-mer sequence, is derived from the KRAS activating oncogene mutation and serves as an immune potentiator. This peptide possesses immunogenic properties and can be utilized for the development of a KRAS vaccine.
T62228	KRAS G12D inhibitor 14	Ras	GPCR/G Protein; MAPK
	KRAS G12D inhibitor 14 是一种 KRAS G12D 的有效抑制剂，能够结合 KRAS G12D 蛋白 (Kd: 33 nM)。KRAS G12D inhibitor 14 抑制 KRAS G12D (KRAS G12D-GTP) 的活性形式，但对 KRAS G13D 无抑制作用。
T36761	KRAS inhibitor-10
	KRAS inhibitor-10 (WO2021005165 A1, compound 11) is a potent and selective inhibitor of RAS proteins, with a specific focus on KRAS proteins. This orally active anti-cancer agent demonstrates strong efficacy in cancer research, specifically in pancreatic cancer, breast cancer, multiple myeloma, leukemia, and lung cancer. KRAS inhibitor-10 is classified as a tetrahydroisoquinoline compound. Its inhibitory properties provide valuable insights and potential therapeutic applications in the field of ...
T40282	KRAS G12D inhibitor 7
	KRAS G12D inhibitor 7, is a highly potent inhibitor specifically targeting KRAS G12D.
T11774	KRAS inhibitor-7	Ras	GPCR/G Protein; MAPK
	KRAS inhibitor-7 is a potent KRAS G12C inhibitor.
T11775	KRAS inhibitor-8	Ras	GPCR/G Protein; MAPK
	KRAS inhibitor-8 is a potent KRAS G12C inhibitor.
T11772	KRAS inhibitor-4	Others	Others
	KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor.
T77808	Kras binder 12

T40285	KRAS G12C inhibitor 18
	KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.
T11773	KRAS inhibitor-6	Ras	GPCR/G Protein; MAPK
	KRAS inhibitor-6 is a potent KRAS G12C inhibitor.
T77806	KRAS inhibitor FB9

T40281	KRAS G12D inhibitor 6
	KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.
T40246	KRAS G12D inhibitor 5
	KRAS G12D inhibitor 5 is a KRAS G12D inhibitor for the potential treatment of pancreatic cancer.
T40272	KRAS mutant protein inhibitor 1
	KRAS mutant protein inhibitor 1 is a KRAS mutant protein inhibitor for potential treatment in cancer.
T9674	KRAS G12D inhibitor 1
	KRAS G12D inhibitor 1 (例 243) 是一种KRAS G12D 抑制剂，对KRAS G12D 介导的 ERK 磷酸化的IC50值为0.8 nM。
T11779	KRas G12C inhibitor 4	Ras	GPCR/G Protein; MAPK
	KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.
T11778	KRas G12C inhibitor 3	Ras	GPCR/G Protein; MAPK
	KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.
T11769	KRAS G12C inhibitor 15	Ras	GPCR/G Protein; MAPK
	KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .
T11780	KRAS G12C inhibitor 5	Ras	GPCR/G Protein; MAPK
	KRAS G12C inhibitor 5 is a KRas G12C inhibitor.
T11771	KRAS G12C inhibitor 17	Ras	GPCR/G Protein; MAPK
	KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.
T11768	KRAS G12C inhibitor 14	Ras	GPCR/G Protein; MAPK
	KRAS G12C inhibitor 14 是一种有效的 KRAS G12C 抑制剂（IC50= 18 nM）。
T11767	KRAS G12C inhibitor 13	Ras	GPCR/G Protein; MAPK
	KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .
T11776	KRas G12C inhibitor 1	Ras	GPCR/G Protein; MAPK
	KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
T11770	KRAS G12C inhibitor 16	Ras	GPCR/G Protein; MAPK
	KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.
T11777	KRas G12C inhibitor 2	Ras	GPCR/G Protein; MAPK
	KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.
T77802	KRAS G12C inhibitor 1R

T77804	KRAS G12D mutation regulator 4

T77805	KRAS G12C mutant protein inhibitor A-1

T78651	Glecirasib JAB-21822,KRAS G12C inhibitor 36	Ras	GPCR/G Protein; MAPK
	Glecirasib (KRAS G12C inhibitor 36) 作为潜在的KRAS G12C抑制剂，在Ras蛋白家族中发挥作用，对细胞内信号传递具重要影响，并在生长发育中扮演关键角色。本化合物显示出研究KRAS G12C介导的癌症潜力。
T63928	KRAS inhibitor-21
	KRAS inhibitor-21 (22b) 是 KRAS G12C 抑制剂 (IC50<0.01 μM)，能够用于研究癌症。
T62737	KRAS inhibitor-15
	KRAS inhibitor-15 (compound 3-19) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.954 μM)。KRAS inhibitor-15 在 MIA PaCA-2，A549 细胞中表现出 p-ERK 抑制作用，IC50s 分别为 2.03，>33.3 μM。KRAS inhibitor-15 具有潜力进行胰腺癌、结直肠癌和肺癌的研究。
T63164	KRAS inhibitor-13
	KRAS inhibitor-13 (compound 5-6) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.883 μM)。KRAS inhibitor-13 在 MIA PaCA-2，A549 细胞中具有 p-ERK 抑制效果，其 IC50 值分别为 5.9，>100 μM。 KRAS inhibitor-13 具有潜力进行胰腺癌、结直肠癌和肺癌的研究。
T79147	KRAS degrader-1
	KRAS degrader-1（compound 1）是通过自噬-溶酶体途径降解特定蛋白的高效KRAS降解剂。
T72659	KRAS inhibitor-3
	KRAS inhibitor-3，一种高效KRAS抑制剂，具有强大的亲和力，能够与野生型及致癌型KRAS突变体紧密结合（KD值：KRAS WT为0.28 μM，KRAS G12C为0.63 μM，KRAS G12D为0.37 μM，KRAS Q61H为0.74 μM）。该化合物还能干扰KRAS与Raf之间的相互作用。
T72599	KRAS inhibitor-11
	KRAS inhibitor-11 是一种 KRAS 抑制剂。
T63235	KRAS inhibitor-14
	KRAS inhibitor-14 是 KRAS G12C 的有效抑制剂(IC50: 0.249 μM)。KRAS inhibitor-14 在 MIA PaCA-2，A549 细胞中表现出 p-ERK 抑制作用，IC50s 分别为 1.12，>33.3 μM。KRAS inhibitor-14 对胰腺癌、结直肠癌和肺癌的具有研究潜力。
T62981	KRAS inhibitor-17
	KRAS inhibitor-17 (compound 3-9) 是一种 KRAS G12C 的有效抑制剂 (IC50: 3.37 μM)。KRAS inhibitor-17 具有 p-ERK 抑制作用，在 MIA PaCA-2 细胞的 IC50=9.25 μM，在 A549 细胞中的 IC50 >33.3 μM。KRAS inhibitor-17 具有潜力进行胰腺癌，结直肠癌和肺癌的研究。
T62751	KRAS inhibitor-12
	KRAS inhibitor-12 (compound 6-1) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.537 μM)。KRAS inhibitor-12 在 MIA PaCA-2，A549 细胞中表现出 p-ERK 抑制作用，其 IC50 值分别为 1.3，3.7 μM。 KRAS inhibitor-12 具有潜力进行胰腺癌，结直肠癌和肺癌的研究。
T62752	KRAS inhibitor-16
	KRAS inhibitor-16 (compound 3-11) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.457 μM)。KRAS inhibitor-16 在 MIA PaCA-2，A549 细胞中表现出 p-ERK 抑制作用，IC50s 分别为 3.06，11.1 μM。 KRAS inhibitor-16 具有潜力进行胰腺癌，结直肠癌和肺癌的研究。
T62784	KRAS inhibitor-18
	KRAS inhibitor-18 (compound 3-10) 是一种 KRAS G12C 的有效抑制剂 (IC50: 4.74 μM)。KRAS inhibitor-18 在 MIA PaCA-2，A549 细胞中表现出 p-ERK 抑制作用，IC50s 分别为 66.4，11.1 μM。KRAS inhibitor-18 具有潜力进行胰腺癌、结直肠癌和肺癌的研究。
T79800	pan-KRAS-IN-2	Ras	GPCR/G Protein; MAPK
	Pan-KRAS-IN-2（compound 6）是一种抑制剂，对KRAS WT及其多种突变体（G12D、G12C、G12V、G12S、G12A、Q61H）表现出极高的抑制活性，其IC50均不超过10 nM；然而对KRAS G13D的抑制活性较低，IC50超过10 μM。
T79162	SOS1/KRAS-IN-1	Ras	GPCR/G Protein; MAPK
	SOS1/KRAS-IN-1(Compound 2)为针对SOS1/KRAS介导的疾病进行研究而设计的抑制剂。
T64142	KRAS G12C inhibitor 46
	KRAS G12C inhibitor 46 是一种 KRAS G12C 的有效抑制剂。
T63807	KRAS G12C inhibitor 33
	KRAS G12C inhibitor 33 是 KRAS G12C 抑制剂，能够用于研究癌症。
T63501	KRAS G12C inhibitor 30
	KRAS G12C inhibitor 30 是 KRAS G12C 的抑制剂，能够用于研究癌症。
T63577	KRAS G12D inhibitor 11
	KRAS G12D inhibitor 11 是 KRAS G12D 的有效抑制剂。其中 Ras 蛋白家族是重要的细胞内信号分子，在生长发育中起重要作用。KRAS G12D inhibitor 11 对 KRAS G12D 介导的癌症表现出研究潜力。
T72394	KRAS G12D inhibitor 3
	KRAS G12D inhibitor 3 是一种KRAS G12D 抑制剂，其IC50小于500 nM，具有抗肿瘤作用。

化合物

KRAS G12D inhibitor 18

Cat.No: T78212

Synonym: KRAS G12D IN 18

Target: Others

KRAS inhibitor-9

Cat.No: T8756

Synonym: DUN09716

Target: Apoptosis, Ras

KRAS G12C inhibitor 19

Cat.No: T40286

Target: Ras

KRAS G13D peptide, 25 mer

Cat.No: T38936

Synonym: KRAS G13D peptide, 25 mer

KRAS G12D inhibitor 14

Cat.No: T62228

Target: Ras

KRAS inhibitor-10

Cat.No: T36761

KRAS G12D inhibitor 7

Cat.No: T40282

KRAS inhibitor-7

Cat.No: T11774

Target: Ras

KRAS inhibitor-8

Cat.No: T11775

Target: Ras

KRAS inhibitor-4

Cat.No: T11772

Target: Others

Kras binder 12

Cat.No: T77808

KRAS G12C inhibitor 18

Cat.No: T40285

KRAS inhibitor-6

Cat.No: T11773

Target: Ras

KRAS inhibitor FB9

Cat.No: T77806

KRAS G12D inhibitor 6

Cat.No: T40281

KRAS G12D inhibitor 5

Cat.No: T40246

KRAS mutant protein inhibitor 1

Cat.No: T40272

KRAS G12D inhibitor 1

Cat.No: T9674

KRas G12C inhibitor 4

Cat.No: T11779

Target: Ras

KRas G12C inhibitor 3

Cat.No: T11778

Target: Ras

KRAS G12C inhibitor 15

Cat.No: T11769

Target: Ras

KRAS G12C inhibitor 5

Cat.No: T11780

Target: Ras

KRAS G12C inhibitor 17

Cat.No: T11771

Target: Ras

KRAS G12C inhibitor 14

Cat.No: T11768

Target: Ras

KRAS G12C inhibitor 13

Cat.No: T11767

Target: Ras

KRas G12C inhibitor 1

Cat.No: T11776

Target: Ras

KRAS G12C inhibitor 16

Cat.No: T11770

Target: Ras

KRas G12C inhibitor 2

Cat.No: T11777

Target: Ras

KRAS G12C inhibitor 1R

Cat.No: T77802

KRAS G12D mutation regulator 4

Cat.No: T77804

KRAS G12C mutant protein inhibitor A-1

Cat.No: T77805

Cat.No: T78651

Synonym: JAB-21822,KRAS G12C inhibitor 36

Target: Ras

KRAS inhibitor-21

Cat.No: T63928

KRAS inhibitor-15

Cat.No: T62737

KRAS inhibitor-13

Cat.No: T63164

KRAS degrader-1

Cat.No: T79147

KRAS inhibitor-3

Cat.No: T72659

KRAS inhibitor-11

Cat.No: T72599

KRAS inhibitor-14

Cat.No: T63235

KRAS inhibitor-17

Cat.No: T62981

KRAS inhibitor-12

Cat.No: T62751

KRAS inhibitor-16

Cat.No: T62752

KRAS inhibitor-18

Cat.No: T62784

pan-KRAS-IN-2

Cat.No: T79800

Target: Ras

SOS1/KRAS-IN-1

Cat.No: T79162

Target: Ras

KRAS G12C inhibitor 46

Cat.No: T64142

KRAS G12C inhibitor 33

Cat.No: T63807

KRAS G12C inhibitor 30

Cat.No: T63501

KRAS G12D inhibitor 11

Cat.No: T63577

KRAS G12D inhibitor 3

Cat.No: T72394

Cat. No.	Product Name	Target	Signaling Pathways
T5S0777	Phellodendrine chloride	Others	Others
	Phellodendrine chloride 是一种Phellodendron amurense 中的生物碱。它通过巨胞饮抑制营养物质的吸收，进而抑制 KRAS 突变的胰腺癌细胞的增殖。

天然产物

Phellodendrine chloride

Cat.No: T5S0777

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼