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89

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T24928	UPR-IN-17# UPR inhibitor-17#,UPR IN 17#,UPR inhibitor 17#
	UPR-IN-17# is an effective pan-inhibitor of the unfolded protein response.
T6854	GSK621	Apoptosis; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	GSK621 是一种特异性AMPK 激动剂，对 AML 细胞系的IC50值为13-30 μM。它可诱导自噬和凋亡，还可诱导eiF2α磷酸化。
T9110	Ceapin-A7	Others	Others
	Ceapin-A7 是内质网应激 ATF6α信号的选择性阻断剂(IC50:0.59 μM)，可用于探讨 ATF6α 促细胞活化的机制及其在病理环境中的作用。
T9349	IXA4	IRE1	Cell Cycle/Checkpoint
	IXA4 是一种高选择性、无毒的 IRE1/XBP1s 激活剂，通过激活 IRE1 来减少 APP 的分泌。它刺激的 IRE1 激活也增强了胰腺功能。
T17309	(R)-(-)-Ibuprofen levibuprofen,(R)-Ibuprofen	NF-κB	NF-κB
	(R)-(-)-Ibuprofen ((R)-Ibuprofen) 是 Ibuprofen 的 R 型异构体，对 COX 无作用，可以抑制 NF-κB 的活化；(R)-(-)-Ibuprofen 具有抗炎作用，可用于缓解疼痛的研究。
T21224	(+)-Fluprostenol Fluprostenol, (+)-,Travoprost acid,AL-5848,曲伏前列素酸	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	(+)-Fluprostenol (AL-5848) 是前列腺素 F2 α 的类似物，是一种前列腺素 F2α 受体 PTGFR 激动剂，可降低输卵管糖蛋白 1 (OVGP1) 的表达。
T6849	Uprosertib GSK2141795,GSK795,优普色替	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Uprosertib (GSK2141795) 是一种有效的，选择性的 Akt 广谱抑制剂，对 Akt1/Akt2/Akt3 的 IC50值分别为 180/328/38 nM。
T16724	Razuprotafib AKB-9778	Phosphatase; Others	Metabolism; Others
	Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂，抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外，它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化，增强 ANG1 诱导的 TIE2 活化，并刺激 TIE2 通路中信号分子的磷酸化。
T3496	Buprofezin 噻嗪酮,NNI 750,Applaud,Buprofezine	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Buprofezin (Applaud) 是一种杀虫剂，通过抑制几丁质合成起作用，在体外还可以剂量依赖性地增加活性氧的产生。
T0324	Isoxsuprine hydrochloride Duvadilan,Isolait,盐酸异克舒令,盐酸苯氧丙酚胺	Adrenergic Receptor; iGluR	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Isoxsuprine hydrochloride (Isolait) 是 β 肾上腺素受体激动剂和NMDA 受体拮抗剂，对子宫肌层和胎盘的 β 肾上腺素受体的Ki 值分别为 13.65 和 3.48 μM。
T60191	Cuprous iodide Iodocopper,Copper (I) iodide	Antibiotic	Microbiology/Virology
	Cuprous iodide (Iodocopper) 是一种抗菌化合物。
T0302	Triflupromazine hydrochloride Neoprin,盐酸三氟丙嗪,Fluopromazine hydrochloride,Fluorofen,Flumazin	Dopamine Receptor; 5-HT Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Triflupromazine hydrochloride (Fluopromazine hydrochloride) 是一种抗精神病药物，是多巴胺 D1/D2 受体拮抗剂。
T60707	Quinupramine
	Quinupramine 具有口服活性的抗抑郁剂，其抗抑郁活性与中枢血清素系统有关，与 β- 肾上腺素能系统无关。Quinupramine 能够渗入中枢神经系统并且影响某些神经传递的过程。
T68093	Lobuprofen	COX	Immunology/Inflammation; Neuroscience
	Lobuprofen 是一种小分子COX 抑制剂，可用于治疗神经系统疾病。
T0448	(S)-(+)-Ibuprofen 左旋布洛芬,Dexibuprofen,(S)-Ibuprofen,(S)-(+)-布洛芬	BCL; Thrombin; Cysteine Protease; COX; PPAR	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome
	(S)-(+)-Ibuprofen (Dexibuprofen) 是 Ibuprofen 的 S(+)-对映异构体，能够有效的抑制COX-1(IC50:2.1 μM)和COX-2(IC50:1.6 μM)，。它具有抗癌、退热、止痛，抗炎的效果。
T1394	Ibuprofen Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil	COX	Immunology/Inflammation; Neuroscience
	Ibuprofen (Advil) 是一种丙酸衍生物和非甾体抗炎药 (NSAID)，具有抗炎、镇痛和解热作用。它是COX-1和COX-2的抑制剂，IC50值分别为 13 和 370 μM，导致前列腺素和血栓素前体的形成减少。
T6540	Ibuprofen Lysine 布洛芬赖氨酸盐,Neoprofen	COX	Immunology/Inflammation; Neuroscience
	Ibuprofen Lysine (Neoprofen) 是一种非甾体抗炎药。
T6687	Suprofen Maldocil,Suprol,TN-762,舒洛芬,Profenal	COX; PGE Synthase	Immunology/Inflammation; Neuroscience
	Suprofen (Suprol) 是一种非甾体抗炎化合物，对前列腺素合成具有抑制作用。
T27572	Ibuprofen diethylaminoethyl ester Brufen diethylaminoethyl ester,BF-DEAE,BF DEAE	Others	Others
	Ibuprofen diethylaminoethyl ester (BF DEAE) 具有抗炎活性，可作为局部麻醉剂，可用于研究麻风性神经炎等神经系统疾病。
T0378	Oxybuprocaine hydrochloride Risedronic Acid,Oxybuprocaine HCl,奥布卡因盐酸盐	Sodium Channel	Membrane transporter/Ion channel
	Oxybuprocaine hydrochloride (Oxybuprocaine HCl) 是可逆的钠通道阻断剂，可防止角膜，结膜和巩膜中疼痛神经的冲动传播。Oxybuprocaine hydrochloride 专用于眼科与耳鼻喉科。
T7363	Ibuprofen Piconol U75630,匹美诺芬,布洛芬吡啶甲醇	Others	Others
	Ibuprofen Piconol (U75630) 是非甾体抗炎药物，局部使用可缓解原发性热灼伤和晒伤。
T41303	Isoflupredone Delta-Fluorocortisone,Isoflupredona,异氟泼尼松,Isoflupredonum,9-Fluoroprednisolone	Others	Others
	Isoflupredone (Isoflupredonum) 是一种合成的皮质类固醇，通过与动物 (如马) 的糖皮质激素和矿皮质激素受体结合抑制炎症细胞和抑制炎症介质的表达在生物体内发挥作用。Isoflupredone 具有抗炎和免疫抑制作用，可应用于治疗各种肌肉骨骼、过敏性和全身炎症性疾病。
T6472	Difluprednate Myser,Epitopic,二氟孕甾丁酯,CM 9155	Others	Others
	Difluprednate (Myser) 是一种可用于术后眼睛疼痛和炎症的皮质类固醇。
T40417	Ethylhydrocupreine hydrochloride Optochin hydrochloride,乙氢去甲奎宁盐酸盐；奥普托欣盐酸盐	Antibacterial; Parasite	Microbiology/Virology
	Ethylhydrocupreine hydrochloride (Optochin hydrochloride) 是奎宁的一种衍生物，具有抗菌作用，可抑制肺炎链球菌的活性。Ethylhydrocupreine hydrochloride 具有抗疟活性，对 Plasmodium falciparum 的IC50为 25.75 nM。Ethylhydrocupreine hydrochloride 是Gallus gallus2 受体 (ggTas2r1，ggTas2r2和ggTas2r7) 激动剂。
T28886	Suprafenacine N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide	Microtubule Associated	Cytoskeletal Signaling
	Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) 是一种细胞渗透性微管去稳定剂，可在 G2/M 期诱导细胞周期停滞和细胞凋亡。它与微管结合并抑制秋水仙碱连接处的聚集。它对癌细胞有选择性，包括耐药癌细胞。
T27288	Esuprone LU-43839,LU 43839,LU43839	MAO	Metabolism; Neuroscience
	Esuprone (LU-43839) 是一种新型可逆且具有高选择性的MAO-A 抑制剂，具有抗惊厥活性，可用于治疗抑郁症。
T8580	Bupranolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bupranolol 是竞争性的、口服活性的、非选择性的β-adrenoceptor 拮抗剂，无固有的拟交感神经活性。
T9047	Fluprednisolone NSC-47439,NSC 47439,氟泼尼龙,NSC47439	Others	Others
	Fluprednisolone (NSC-47439) 是一种合成糖皮质激素，具有抗炎特性。
T21193	Isoflupredone Acetate	Others	Others
	Isoflupredone Acetate 是一种具有局部抗炎活性的皮质类固醇。
T65013	Cuprizone	Others	Others
	Cuprizone 是一种铜螯合剂。Cuprizone 可用于诱导小鼠精神分裂症。Cuprizone 可诱导少突胶质细胞死亡，诱导脱髓鞘反应。
T15428	Uprosertib hydrochloride GSK2141795 (hydrochloride)	Others	Others
	Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively).
T32978	Luprostiol Reprodin,Equestrolin,Prosolvin
	Luprostiol is a prostaglandin analog.
T31398	Dexibuprofen lysine L669455,L 669455,L-669455,Doctrin,L-669,455
	Dexibuprofen (S-ibuprofen) is a non-steroidal anti-inflammatory drug. Most ibuprofen preparations contain a racemic mixture of two isomers. Dexibuprofen as a cyclooxygenase inhibitor.
T20142	Tafluprost acid UNII-WTV8EPZ396
	Tafluprost acid is a selective agonist at the prostaglandin F receptor.
T11605	(-)-Ibuprofenamide (R)-Ibuprofenamide	COX	Immunology/Inflammation; Neuroscience
	(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.
T23417	Talsupram hydrochloride	Others	Others
	noradrenalin re-uptake inhibitor
T33631	Neocuproine Neocuproin
	Neocuproine 是一种铜（I）螯合剂，可增强电场刺激引起的输精管收缩的嘌呤能成分，常被用作配位试剂和铜离子检测剂。Neocuproine 与铜离子形成稳定的络合物，并可在某些化学反应和分析方法中起到催化作用。Neocuproine 作为铁和钴上的氧化还原活性配体平台，对NSC34细胞氧化损伤的保护作用。
T13828	Isoxsuprine-monoester-1	Others	Others
	Isoxsuprine-monoester-1 is a monoester of isoxsuprine,and is a long acting peripheral vasodilator.
TP2285	Quinupristin-Dalfopristin Complex (mesylate)	Others	Others
	Quinupristin-Dalfopristin Complex is a mixture of two streptogramin antibiotics. Quinupristin-dalfopristin complex is a mixture of two streptogramin antibiotics, dalfopristin, and quinupristin. Streptogramin antibiotics are divided into types A and B, whi
T37956	Tafluprost ethyl amide
	Tafluprost ethyl amide 是一种前列腺素衍生物。Tafluprost ethyl amide 能降低眼压 (IOP)，影响睫毛生长。Tafluprost ethyl amide 可用于抗青光眼眼药及化妆品。
T32684	Leuprolide (1-3) Leuprorelin
	Leuprolide (1-3) is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty.
T11604	Ibuprofen-d3 Ibuprofen D3,(±)-Ibuprofen D3	Others	Others
	Ibuprofen D3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor (IC50s: 13 μM and 370 μM).
T71834	Ibuprofen ethyl ester
	Ibuprofen ethyl ester is a derivative of Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) that is known to inhibit PGH synthase-1 and PGH synthase-2.
T60292	Ibuprofen sodium
	Ibuprofen ((±)-Ibuprofen) sodium 是一种口服活性的选择性COX-1抑制剂，IC50值为 13 μM。Ibuprofen sodium 抑制细胞增殖、血管生成，并诱导细胞凋亡 (apoptosis)。Ibuprofen sodium 是一种非甾体抗炎剂和一氧化氮 (NO) 供体。Ibuprofen sodium 可用于疼痛、肿胀、炎症、感染、免疫学、癌症的研究。
TP1473	Velmupressin c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2
	c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 is a selective and short-acting peptidic V2 receptor (V2R) agonist with EC50s of 0.07nM and 0.02 nM for hV2R and rV2R, respectively.
T75275	Quinupristin mesylate
	Quinupristin mesylate 为链球菌素类抗生素，通过阻断细菌核糖体亚基中的肽键合成，阻止多肽链延伸，并促进不完全蛋白链分离。
T37813	Fluprostenol methyl ester
	Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals. The isopropyl ester of fluprostenol (travoprost) is an effective ocular hypotensive drug. CAY10532 is a methyl ester analog of fluprostenol.
T16941	Stauprimide	Others	Others
	Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which causes down-regulation of MYC transcription.
T41363	1-Oxo Ibuprofen
	1-Oxo Ibuprofen 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T41363，CAS号为 65813-55-0。
T29070	Uproleselan
	Uproleselan has antithrombotic and antineoplastic properties.

化合物

Cat.No: T24928

Synonym: UPR inhibitor-17#,UPR IN 17#,UPR inhibitor 17#

Cat.No: T6854

Target: Apoptosis, AMPK, Autophagy

Cat.No: T9110

Target: Others

Cat.No: T9349

Target: IRE1

(R)-(-)-Ibuprofen

Cat.No: T17309

Synonym: levibuprofen,(R)-Ibuprofen

Target: NF-κB

(+)-Fluprostenol

Cat.No: T21224

Synonym: Fluprostenol, (+)-,Travoprost acid,AL-5848,曲伏前列素酸

Target: Prostaglandin Receptor

Cat.No: T6849

Synonym: GSK2141795,GSK795,优普色替

Target: Akt

Cat.No: T16724

Synonym: AKB-9778

Target: Phosphatase, Others

Cat.No: T3496

Synonym: 噻嗪酮,NNI 750,Applaud,Buprofezine

Target: Reactive Oxygen Species

Isoxsuprine hydrochloride

Cat.No: T0324

Synonym: Duvadilan,Isolait,盐酸异克舒令,盐酸苯氧丙酚胺

Target: Adrenergic Receptor, iGluR

Cat.No: T60191

Synonym: Iodocopper,Copper (I) iodide

Target: Antibiotic

Triflupromazine hydrochloride

Cat.No: T0302

Synonym: Neoprin,盐酸三氟丙嗪,Fluopromazine hydrochloride,Fluorofen,Flumazin

Target: Dopamine Receptor, 5-HT Receptor, AChR, Autophagy

Cat.No: T60707

Cat.No: T68093

Target: COX

(S)-(+)-Ibuprofen

Cat.No: T0448

Synonym: 左旋布洛芬,Dexibuprofen,(S)-Ibuprofen,(S)-(+)-布洛芬

Target: BCL, Thrombin, Cysteine Protease, COX, PPAR

Cat.No: T1394

Synonym: Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil

Target: COX

Ibuprofen Lysine

Cat.No: T6540

Synonym: 布洛芬赖氨酸盐,Neoprofen

Target: COX

Cat.No: T6687

Synonym: Maldocil,Suprol,TN-762,舒洛芬,Profenal

Target: COX, PGE Synthase

Ibuprofen diethylaminoethyl ester

Cat.No: T27572

Synonym: Brufen diethylaminoethyl ester,BF-DEAE,BF DEAE

Target: Others

Oxybuprocaine hydrochloride

Cat.No: T0378

Synonym: Risedronic Acid,Oxybuprocaine HCl,奥布卡因盐酸盐

Target: Sodium Channel

Ibuprofen Piconol

Cat.No: T7363

Synonym: U75630,匹美诺芬,布洛芬吡啶甲醇

Target: Others

Cat.No: T41303

Synonym: Delta-Fluorocortisone,Isoflupredona,异氟泼尼松,Isoflupredonum,9-Fluoroprednisolone

Target: Others

Cat.No: T6472

Synonym: Myser,Epitopic,二氟孕甾丁酯,CM 9155

Target: Others

Ethylhydrocupreine hydrochloride

Cat.No: T40417

Synonym: Optochin hydrochloride,乙氢去甲奎宁盐酸盐；奥普托欣盐酸盐

Target: Antibacterial, Parasite

Cat.No: T28886

Synonym: N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide

Target: Microtubule Associated

Cat.No: T27288

Synonym: LU-43839,LU 43839,LU43839

Target: MAO

Cat.No: T8580

Target: Adrenergic Receptor

Fluprednisolone

Cat.No: T9047

Synonym: NSC-47439,NSC 47439,氟泼尼龙,NSC47439

Target: Others

Isoflupredone Acetate

Cat.No: T21193

Target: Others

Cat.No: T65013

Target: Others

Uprosertib hydrochloride

Cat.No: T15428

Synonym: GSK2141795 (hydrochloride)

Target: Others

Cat.No: T32978

Synonym: Reprodin,Equestrolin,Prosolvin

Dexibuprofen lysine

Cat.No: T31398

Synonym: L669455,L 669455,L-669455,Doctrin,L-669,455

Tafluprost acid

Cat.No: T20142

Synonym: UNII-WTV8EPZ396

(-)-Ibuprofenamide

Cat.No: T11605

Synonym: (R)-Ibuprofenamide

Target: COX

Talsupram hydrochloride

Cat.No: T23417

Target: Others

Cat.No: T33631

Synonym: Neocuproin

Isoxsuprine-monoester-1

Cat.No: T13828

Target: Others

Quinupristin-Dalfopristin Complex (mesylate)

Cat.No: TP2285

Target: Others

Tafluprost ethyl amide

Cat.No: T37956

Leuprolide (1-3)

Cat.No: T32684

Synonym: Leuprorelin

Cat.No: T11604

Synonym: Ibuprofen D3,(±)-Ibuprofen D3

Target: Others

Ibuprofen ethyl ester

Cat.No: T71834

Ibuprofen sodium

Cat.No: T60292

Cat.No: TP1473

Synonym: c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2

Quinupristin mesylate

Cat.No: T75275

Fluprostenol methyl ester

Cat.No: T37813

Cat.No: T16941

Target: Others

1-Oxo Ibuprofen

Cat.No: T41363

Cat.No: T29070

Cat. No.	Product Name	Target	Signaling Pathways
TQ0203	Tafluprost MK2452,AFP-168,他氟前列素	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Tafluprost 是一种抗青光眼前列腺素（PG）类似物。
T35000	Uproleselan sodium GMI 1271,GMI1271,GMI-1271
	Uproleselan sodium (GGI-1271) is a small molecule E-selector antagonist originally targeted at AML as an adjuvant to standard chemotherapy for hematological malignancies.
TN3343	Acetylisocupressic acid	Others	Others
	Acetylisocupressic acid是一种天然产物，属于南洋杉科南洋杉属，其产品编号为 TN3343，CAS号为 52992-82-2。Acetylisocupressic acid可用作对照参考。
T10072	2-Hydroxy Ibuprofen 2-羟基布洛芬,(±)-2-Hydroxy Ibuprofen	Others	Others
	2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1/COX-2 (IC50s: 13 μM/370 μM).
TN4277	Isocupressic acid	cAMP; P450; PKA	GPCR/G Protein; Metabolism; Tyrosine Kinase/Adaptors
	Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial ce
TN3730	Cupressuflavone	Others	Others
	Cupressuflavone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3730，CAS号为 3952-18-9。
TN3005	4',4'''-Di-O-methylcupressuflavone	Others	Others
	4',4'''-Di-O-methylcupressuflavone is a natural product from Phyllanthus niruri Linn.
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Cat.No: TQ0203

Synonym: MK2452,AFP-168,他氟前列素

Target: Prostaglandin Receptor

Uproleselan sodium

Cat.No: T35000

Synonym: GMI 1271,GMI1271,GMI-1271

Acetylisocupressic acid

Cat.No: TN3343

Target: Others

2-Hydroxy Ibuprofen

Cat.No: T10072

Synonym: 2-羟基布洛芬,(±)-2-Hydroxy Ibuprofen

Target: Others

Isocupressic acid

Cat.No: TN4277

Target: cAMP, P450, PKA

Cupressuflavone

Cat.No: TN3730

Target: Others

4',4'''-Di-O-methylcupressuflavone

Cat.No: TN3005

Target: Others

Cat.No: T36954

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