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kynureninase/KYNU Protein, Human, Recombinant (His)

kynureninase/KYNU Protein, Human, Recombinant (His)

产品编号 TMPY-02479
别名: KYNUU, kynureninase

kynureninase/KYNU Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 53.80 kDa and the accession number is Q16719.

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kynureninase/KYNU Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
50 μg ¥ 3,820 5日内发货
药物设计专题培训
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
产品目录号及名称: kynureninase/KYNU Protein, Human, Recombinant (His) (TMPY-02479)
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生物活性
技术参数
产品性质
参考文献
生物活性 Measured by its ability to oxidize 3-hydroxykynurenine. The specific activity is > 200 pmoles/min/μg.
产品描述 kynureninase/KYNU Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 53.80 kDa and the accession number is Q16719.
种属 Human
表达系统 Baculovirus Insect Cells
标签 C-His
蛋白编号 Q16719
别名 KYNUU, kynureninase
蛋白构建 The Human KYNU (Q16719) (Met1-Asn465) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度 > 92 % as determined by SDS-PAGE
分子量 53.80 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 25% gly.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 KYNU (Kynureninase) is a Protein Coding gene. KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Genetic studies in the mouse and the human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension was previously detected in the Chinese Han population. The results show that the rare KYNU variant Arg188Gln affects kynureninase activity and are consistent with the hypothesis that this mutation can predispose to essential hypertension. Diseases associated with KYNU include Hydroxykynureninuria and Vertebral, Cardiac, Renal, And Limb Defects Syndrome 2.

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Keywords

kynureninase/KYNU Protein, Human, Recombinant (His) KYNUU kynureninase recombinant recombinant-proteins proteins protein

 

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