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Anti-BMI-1 Antibody (9H107)
还可以产品编号 TMAY-00110
Anti-BMI-1 Antibody (9H107) 是一种 Rabbit 抗体，靶向 BMI-1。Anti-BMI-1 Antibody (9H107) 可用于 IHC-P。
Anti-BMI-1 Antibody (9H107)
Anti-BMI-1 Antibody (9H107)
还可以产品编号 TMAY-00110
Anti-BMI-1 Antibody (9H107) 是一种 Rabbit 抗体，靶向 BMI-1。Anti-BMI-1 Antibody (9H107) 可用于 IHC-P。
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产品介绍
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抗原信息
| 产品描述 | Anti-BMI-1 Antibody (9H107) is a Rabbit antibody targeting BMI-1. Anti-BMI-1 Antibody (9H107) can be used in IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 9H107 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human BMI1 in human skeletal muscle with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the Human BMI1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Polycomb group member protein BMI1 is involved in maintaining cell identity, proliferation, differentiation and human oncogenesis. BMI1 mRNA expression in whole blood might represent a new biomarker for the diagnosis and prognosis of NSCLC. In human myoblasts, BMI1 overexpression increases mitochondrial activity, leading to an enhanced energetic state with increased ATP production and concomitant protection against DNA damage both in vitro and upon xenografting in a severe dystrophic mouse model. BMI1 inhibition suppressed proliferation of leukemia cells through NOTCH signaling which functions downstream of BMI1, suggesting that BMI1 inhibitors can be candidate targeted drugs against leukemia. BMI1 decreases ATR activation through a mechanism that involves binding to TOPBP1 and/or ATR. BMI1 over-expression may be useful in identifying patients who might benefit from novel therapies directed at reversing the chromatin-modifying functions of BMI1. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to the center region of the Human BMI1 |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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