s-14

PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor that acts by targeting the cyclic adenosine monophosphate (cAMP) cAMP-response element-binding protein (CREB) pathway.

TF-S14 是一种 RORγt 的反向激动剂，它通过结合 RORγt 并抑制其活性来减少 Th17 细胞相关细胞因子的产生，包括 IL-17A、IL-21 和 IL-22。TF-S14 可用于研究自身免疫疾病和同种异体移植中的排斥反应。

GNS-1481为一种新型EGFR激酶抑制剂，专门针对EGFR的T790M突变异构体。

WMS-1405是ifenprodil的衍生物。作为一种高效的NR2B选择性NMDA受体拮抗剂，WMS-1405展示出了5.4 nM的Ki值。通过中心构建基块合成，WMS-1405由于其基本氮原子与苯基残基之间的特定距离，显示出高NR2B亲和性。WMS-1405具有成为治疗兴奋毒性的NMDA拮抗剂的潜力。

MRS-1477 is used as a TRPV1 positive allosteric modulator (PAM).

S-14671 is a 5-HT1A receptor agonist (pKi = 9.3) with high efficacy and exceptional in vivo potency. S-14671 also acts as a 5-HT2A and 5-HT2C receptor antagonist (both are pKi = 7.8).

UNBS-1450 is a sodium channel antagonist. UNBS-1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin, it is effective against various cancer cell types with an excellent differential toxicity. At low nanomolar concentrations, UNBS-1450 induce

IS-145 is a thromboxane A2 receptor antagonist.

GBS-149 is a novel non-toxic and mammalian-specific LINE-1 inhibitor.

Inobrodib (CBP-IN-1) 是一种口服活性的强选择性p300 CBP 抑制剂，与 p300 和 CBP 结合，Kd 值为 1.3 和 1.7 nM。它抑制前列腺癌细胞系的细胞增殖并降低雄激素受体和 C-MYC 调节的基因表达。

6-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-1H-pyridine-3,4-dicarbonitrile 是一种生物活性化合物，可用于化学和生命科学领域的研究。

Questiomycin A derivatives 14 是一种 Questiomycin A 衍生物。

Fenclozine Maleate (S 1429) 是一种潜在的组胺H1受体拮抗剂 ，可用于研究发热、炎症和疼痛。

S 14506 hydrochloride 是一种5-HT1A 受体完全激动剂。

(2S,3S)-Pterosin S 14-O-glucoside 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124536。

Benazepril hydrochloride (CGS 14824A HCl) 是一种血管紧张素转化酶（ACE）抑制剂，能够作用于高血压。

cIAP1 Ligand-Linker Conjugates 14 consist of an IAP ligand that targets the E3 ubiquitin ligase and a PROTAC linker. These conjugates, known as cIAP1 Ligand-Linker Conjugates 14, are used in the development of SNIPERs[1].

D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is a second messenger that promotes the release of calcium ions from the endoplasmic reticulum.

RS14203为一种IV型环核苷酸磷酸二酯酶(PDE IV)抑制剂，具有口服活性，其主要作用是诱导呕吐。

AS1411-C4-VH032（AS1411-VH032）通过促进MDM2的肿瘤选择性降解，有效缩小肿瘤体积，且未观察到明显毒性。

AS1468240 is a factor Xa inhibitor. It has significant oral anticoagulant activity.

MIPS1455 is a photoactivatable allosteric M1 muscarinic acetylcholine receptor ligand.

GS-143 是选择性的IκBα泛素化抑制剂，抑制 SCFβTrCP1介导的IκBα泛素化作用，IC50=5.2 μM。GS143 抑制NF-κB 的活化和靶基因的转录，并且不抑制蛋白酶体的特性，并具有抗哮喘作用。

RS 14203 is a selective type 4 phosphodiesterase (PDE4) inhibitor.