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Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 2

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Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 2
产品编号 TMAC-03054
别名 p-PAK2 (Ser141), p-PAK2 (S141), PAK2 (p-Ser141), PAK2 (p-S141)

Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PAK2 (Ser141)。Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 可用于 WB。

Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 2

Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 2

Rating icon 还可以
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 2
产品编号 TMAC-03054 别名 p-PAK2 (Ser141), p-PAK2 (S141), PAK2 (p-Ser141), PAK2 (p-S141)

Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PAK2 (Ser141)。Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,485
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100 μL
¥ 2,235
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产品介绍

生物活性
产品描述
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PAK2 (Ser141). Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody can be used in WB.
别名p-PAK2 (Ser141), p-PAK2 (S141), PAK2 (p-Ser141), PAK2 (p-S141)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of extracts from HepG2 cells treated with Adriamycin (0.5uM, 24hours) and Jurkat cells treated with PMA (125ng/ml, 30mins) using PAK2 (Phospho-Ser141) antibody TMAC-03054. The lane on the right is treated with the synthesized peptide.
应用
WB
推荐剂量
WB: 1:500-3000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of serine 141 (Y-L-S(p)-F-T) derived from Human PAK2
抗原种属
human
Uniprot ID
Q13177
化学信息
分子量Actual: 60 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pPAK2 (Ser141)pPAK2 (S141)PAK2 (pSer141)PAK2 (pS141)PAK2 (phospho-Ser141)PAK2 (phospho-S141)

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