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Anti-Phospho-BRCA1 (Ser1423) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-BRCA1 (Ser1423)。Anti-Phospho-BRCA1 (Ser1423) Polyclonal Antibody 可用于 WB,IHC。
Anti-Phospho-BRCA1 (Ser1423) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-BRCA1 (Ser1423)。Anti-Phospho-BRCA1 (Ser1423) Polyclonal Antibody 可用于 WB,IHC。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,485 | 5日内发货 | |
100 μL | ¥ 2,245 | 5日内发货 |
产品描述 | Anti-Phospho-BRCA1 (Ser1423) Polyclonal Antibody is a Rabbit antibody targeting Phospho-BRCA1 (Ser1423). Anti-Phospho-BRCA1 (Ser1423) Polyclonal Antibody can be used in WB,IHC. |
别名 | p-BRCA1 (Ser1423), p-BRCA1 (S1423), BRCA1 (p-Ser1423), BRCA1 (p-S1423) |
Ig Type | IgG |
交叉反应 | Human |
验证活性 | 1. Western blot analysis of extracts from HT29 cells untreated or treated with Anisomycin using BRCA1 (Phospho-Ser1423) Antibody TMAC-00469. 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BRCA1 (Phospho-Ser1423) Antibody TMAC-00469 (left) or the same antibody preincubated with blocking peptide (right). |
应用 | |
抗体种类 | Polyclonal |
宿主来源 | Rabbit |
构建方式 | Polyclonal Antibody |
纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
性状 | Liquid |
缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
研究背景 | The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation |
偶联 | Unconjugated |
其他可选修饰符 | Phospho |
免疫原 | Peptide sequence around phosphorylation site of serine 1423 (H-G-S(p)-Q-P) derived from Human BRCA1 |
抗原种属 | human |
Uniprot ID |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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