购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空

抑制性免疫检查点蛋白 (Co-inhibitory Immune Checkpoint Proteins)

抑制性免疫检查点分子在维持免疫稳态中起着至关重要的作用:它们效应 T 细胞上的表达确保了效应 T 细胞反应的适当紧缩;它们在调节性 T (Treg) 细胞上的表达促进了Treg细胞的抑制功能。阻断共抑制分子已被证实可以增强宿主对各种癌症的免疫应答,在癌症治疗中表现出显著的临床效果。

PD-L1 Protein, Human, Recombinant
TMPY-05208
PD-L1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.2 kDa and the accession number is Q9NZQ7-1.
  • ¥ 4470
现货
规格
数量
CD73 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-06907
CD73 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 61.04 kDa and the accession number is NP_002517.1.
  • ¥ 3820
现货
规格
数量
FGL1 Protein, Human, Recombinant (His)
TMPY-05372
FGL1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 35.5 kDa and the accession number is Q08830.
  • ¥ 3420
现货
规格
数量
IDO Protein, Human, Recombinant
TMPY-02928
IDO Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 45.2 kDa and the accession number is A0A348GSI3.
  • ¥ 3170
现货
规格
数量
B7-H3 Protein, Human, Recombinant (His)
TMPY-02031
B7-H3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48 kDa and the accession number is Q5ZPR3-1.
  • ¥ 2690
现货
规格
数量
CD73/5'-Nucleotidase Protein, Mouse, Recombinant (His)
TMPY-01342
CD73 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.4 kDa and the accession number is Q0VEE0.
  • ¥ 2260
现货
规格
数量
CD47 Protein, Human, Recombinant (His)
TMPJ-00211
CD47 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-45 KDa and the accession number is Q08722.
  • ¥ 620
现货
规格
数量
PD-L1 Protein, Mouse, Recombinant (His)
TMPY-01155
PD-L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is Q3U472.
  • ¥ 1940
现货
规格
数量
PD-L1 Protein, Human, Recombinant (Flag)
TMPJ-00183
PD-L1 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with C-Flag tag. The predicted molecular weight is 35-40 KDa and the accession number is Q9NZQ7.
  • ¥ 500
5日内发货
规格
数量
CD73/5'-Nucleotidase Protein, Human, Recombinant (His)
TMPY-01851
CD73 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is P21589-1.
  • ¥ 4120
现货
规格
数量
PD-L1 Protein, Human, Recombinant (His)
TMPY-04343
PD-L1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is Q9NZQ7-1.
  • ¥ 3170
现货
规格
数量
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated
TMPY-05227
TIM-3 KIM-3 HAVCR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.3 kDa and the accession number is AAL65157.1.
  • ¥ 1950
现货
规格
数量
CD155/PVR Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
TMPY-05597
CD155 PVR Protein, Mouse, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 62.9 kDa and the accession number is Q8K094.
  • ¥ 2940
现货
规格
数量
PD-1 Protein, Human, Recombinant (hFc)
TMPY-04898
PD-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession number is A0A0M3M0G7.
  • ¥ 1700
现货
规格
数量
PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00181
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28 CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
  • ¥ 2260
5日内发货
规格
数量
CD155/PVR Protein, Human, Recombinant (hFc)
TMPY-00699
CD155 PVR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P15151-1.
  • ¥ 2470
现货
规格
数量
CD155/PVR Protein, Mouse, Recombinant (mFc)
TMPY-05791
CD155 PVR Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 60.78 kDa and the accession number is Q8K094.
  • ¥ 2270
现货
规格
数量
PD-1 Protein, Mouse, Recombinant (hFc)
TMPY-05395
PD-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is Q02242.
  • ¥ 1120
现货
规格
数量
PD-1 Protein, Canine, Recombinant (hFc)
TMPY-00233
PD-1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43 kDa and the accession number is XP_543338.3.
  • ¥ 3820
5日内发货
规格
数量
BTNL2 Protein, Human, Recombinant (Isoform 4, His)
TMPH-03822
BTNL2 Protein, Human, Recombinant (Isoform 4, His) is expressed in E. coli with C-6xHis. The accession number is Q9UIR0.
  • ¥ 1800
20日内发货
规格
数量
CD300A Protein, Cynomolgus, Recombinant (His)
TMPK-00561
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX FPR2 expression levels following IgE-mediated activation. CD300A Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 18.73 kDa and the accession number is A0A7N9CE79.
  • ¥ 3100
5日内发货
规格
数量
CD300A Protein, Cynomolgus, Recombinant (Avi)
TMPK-00559
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX FPR2 expression levels following IgE-mediated activation. CD300A Protein, Cynomolgus, Recombinant (Avi) is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19.44 kDa and the accession number is A0A7N9CE79.
  • ¥ 3850
5日内发货
规格
数量
FGL2 Protein, Human, Recombinant (hFc & Flag)
TMPK-00970
Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses. FGL2 is overexpressed in glioma, and its expression level is negatively associated with the prognosis of glioma patients. FGL2 Protein, Human, Recombinant (hFc & Flag) is expressed in HEK293 mammalian cells with N-hFc-Flag tag. The predicted molecular weight is 54.73 kDa and the accession number is Q14314.
  • ¥ 3400
5日内发货
规格
数量
B7-H3 Protein, Human, Recombinant (aa 29-245, hFc)
TMPK-01017
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 Protein, Human, Recombinant (aa 29-245, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 50.1 kDa and the accession number is Q5ZPR3-2.
  • ¥ 2360
5日内发货
规格
数量
CD96 Protein, Human, Recombinant (hFc)
TMPJ-00949
CD96 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 110-160 KDa and the accession number is P40200-2.
  • ¥ 550
5日内发货
规格
数量
PD-L1 Protein, Cynomolgus, Recombinant (His)
TMPJ-00638
PD-L1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-40 KDa and the accession number is G7PSE7.
  • ¥ 700
5日内发货
规格
数量
CD200R1/CRTR2 Protein, Cynomolgus, Recombinant (His)
TMPK-01262
CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand. CD200R1 CRTR2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 28.09 kDa and the accession number is XP_005548207.1.
  • ¥ 3100
5日内发货
规格
数量
LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00321
LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 60-70 KDa and the accession number is P18627.
  • ¥ 2260
5日内发货
规格
数量
CD160 Protein, Rhesus macaque, Recombinant (His)
TMPJ-00627
CD160 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 16-30 KDa and the accession number is G7MG20.
  • ¥ 740
5日内发货
规格
数量
B7-H4 Protein, Rhesus macaque, Recombinant (hFc)
TMPJ-00175
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
  • ¥ 1170
5日内发货
规格
数量
Siglec-9 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00287
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results in increased sialylation. Thus, when the mucin MUC1 is expressed on cancer cells, it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST). Siglec-9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.9 kDa and the accession number is Q9Y336-1.
  • ¥ 5180
5日内发货
规格
数量
PD-1 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
TMPK-00181
Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity. PD-1 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is Q02242.
  • ¥ 5180
5日内发货
规格
数量
Siglec-9 Protein, Human, Recombinant (His & Avi)
TMPK-00286
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results in increased sialylation. Thus, when the mucin MUC1 is expressed on cancer cells, it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST). Siglec-9 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.9 kDa and the accession number is Q9Y336-1.
  • ¥ 3100
5日内发货
规格
数量
ILDR2 Protein, Human, Recombinant (His)
TMPJ-00353
ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasis. The human ILDR2 lumenal domain shares a 99% and 98% homology with the mouse and rat respectively. The human gene encoding ILDR2 is located in a region on Chr1q23–25 that has been associated with type 2 diabetes. ILDR2 plays critical roles in hepatic clearance of lipoproteins and in lipid homeostasis. ILDR2 regulates human dendritic cells (DC2 cells, a subpopulation of polarized DCs that promotes Th2 differentiation). Recent publications reported that ILDR2 displayed negative regulatory functions on human and mouse T cells in various experimental systems. Fusion protein of ILDR2 lumenal domain with an Fc fragment, displays therapeutic effects in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA). ILDR2 represents a novel B7-like ligand that exerts negative immune modulation via interaction with a putative counterpart receptor expressed on activated T cells.
  • ¥ 550
5日内发货
规格
数量
CTLA-4 Protein, Cynomolgus, Recombinant (His)
TMPJ-00636
CTLA-4 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 17-25 KDa and the accession number is G7PL88.
  • ¥ 380
5日内发货
规格
数量
CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00208
CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 60-70 KDa and the accession number is Q08722.
  • ¥ 2260
5日内发货
规格
数量
CD155/PVR Protein, Human, Recombinant (His & Avi)
TMPK-00260
CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the poliovirus receptor, or PVR.
  • ¥ 2360
5日内发货
规格
数量
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
TMPK-00314
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 (4Ig) B7-H3b Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.5 kDa and the accession number is Q5ZPR3-1.
  • ¥ 2660
5日内发货
规格
数量
CTLA-4 Protein, Canine, Recombinant (hFc)
TMPY-00620
CTLA-4 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.1 kDa and the accession number is A0A8C0TW59.
  • ¥ 3170
5日内发货
规格
数量
CD73/5'-Nucleotidase Protein, Human, Recombinant (hFc)
TMPY-05580
CD73 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.5 kDa and the accession number is P21589-1.
  • ¥ 3820
5日内发货
规格
数量
PD-1 Protein, Human, Recombinant (His)
TMPY-00897
PD-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is A0A0M3M0G7.
  • ¥ 2920
现货
规格
数量
CTLA-4 Protein, Human, Recombinant (His), Biotinylated
TMPY-04948
CTLA-4 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is P16410-1.
  • ¥ 1950
5日内发货
规格
数量
CD47 Protein, Human, Recombinant, Biotinylated
TMPY-05191
CD47 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
  • ¥ 1950
现货
规格
数量
Siglec-9 Protein, Human, Recombinant (His)
TMPY-06847
Siglec-9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.48 kDa and the accession number is Q9Y336-1.
  • ¥ 3170
5日内发货
规格
数量
PD-L1 Protein, Human, Recombinant (hFc), Biotinylated
TMPY-05238
PD-L1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52 kDa and the accession number is Q9NZQ7-1.
  • ¥ 1950
5日内发货
规格
数量
PD-1 Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated
TMPY-05295
PD-1 Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 44.5 kDa and the accession number is B0LAJ3.
  • ¥ 2940
5日内发货
规格
数量
CD47 Protein, Mouse, Recombinant
TMPY-05467
CD47 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 13.8 kDa and the accession number is E5Q371.
  • ¥ 5750
5日内发货
规格
数量
CD47 Protein, Human, Recombinant
TMPY-04683
CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
  • ¥ 4470
现货
规格
数量