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LAG-3 Protein, Human, Recombinant

LAG-3 Protein, Human, Recombinant

产品编号 TMPY-04939
别名: LAG-3, lymphocyte-activation gene 3, CD223

LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.

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LAG-3 Protein, Human, Recombinant
规格 价格/CNY 货期 数量
50 μg ¥ 2,260 现货
100 μg ¥ 3,880 5日内发货
200 μg ¥ 6,630 5日内发货
500 μg ¥ 13,410 5日内发货
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产品目录号及名称: LAG-3 Protein, Human, Recombinant (TMPY-04939)
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生物活性
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参考文献
生物活性 Immobilized Recombinant Human LAG3 / CD223 / Lymphocyte activation gene 3 Protein (ECD) at 2μg/mL (100μL/well) can bind Anti-LAG3(BMS)-IgG4 Antibody , the EC50 is 45-130 ng/mL.

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产品描述 LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.
种属 Human
表达系统 HEK293 Cells
标签 Tag Free
蛋白编号 P18627-1
别名 LAG-3, lymphocyte-activation gene 3, CD223
蛋白构建 Human LAG3 (NP_002277.4) (Met1-Arg440)
蛋白纯度 > 90 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC.

TargetMol TargetMol

分子量 45.3 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy

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Keywords

LAG-3 Protein, Human, Recombinant LAG 3 CD 223 LAG3 LAG-3 lymphocyte-activation gene 3 CD-223 CD223 recombinant recombinant-proteins proteins protein

 

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