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SLAMF6 Protein, Mouse, Recombinant (His)

SLAMF6 Protein, Mouse, Recombinant (His)

产品编号 TMPY-01809
别名: SF2000, SLAM family member 6, NTBA, KAL1, KAL1b, Ly108, NTB-A

SLAMF6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.4 kD and the accession number is Q18PG5.

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SLAMF6 Protein, Mouse, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 3,820 5日内发货
1 mg ¥ 24,900 5日内发货
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产品目录号及名称: SLAMF6 Protein, Mouse, Recombinant (His) (TMPY-01809)
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生物活性
技术参数
产品性质
参考文献
生物活性 Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.
产品描述 SLAMF6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.4 kD and the accession number is Q18PG5.
种属 Mouse
表达系统 HEK293 Cells
标签 C-His
蛋白编号 Q18PG5
别名 SF2000, SLAM family member 6, NTBA, KAL1, KAL1b, Ly108, NTB-A
蛋白构建 The Mouse SLAMF6 (NP_109635.1) extracellular domain (Met 1-Asn 239) was fused with a polyhistidine tag at the C-terminus.
蛋白纯度 > 95 % as determined by SDS-PAGE
分子量 24.4 kD (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly18, is a single-pass type I membrane protein that belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly18 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly18 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly18 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly18 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly18 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

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Keywords

SLAMF6 Protein, Mouse, Recombinant (His) SF-2000 SF2000 SLAM family member 6 NTBA KAL1 KAL1b KAL-1 Ly108 NTB-A KAL 1 SF 2000 recombinant recombinant-proteins proteins protein

 

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