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LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated

LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated

产品编号 TMPJ-00321
别名: Lymphocyte activation gene 3 protein, CD223, LAG-3, Protein FDC, LAG3

LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 60-70 KDa and the accession number is P18627.

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LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated
规格 价格/CNY 货期 数量
20 μg ¥ 2,260 5日内发货
100 μg ¥ 6,130 5日内发货
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产品目录号及名称: LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated (TMPJ-00321)
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生物活性
技术参数
产品性质
生物活性 Loaded Anti-Human LAG-3 mAb-Fc on Protein A Biosensor, can bind Biotinylated Human LAG-3-6His-Avi with an affinity constant of 0.17 nM as determined in BLI assay. (Regularly tested)
产品描述 LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 60-70 KDa and the accession number is P18627.
种属 Human
表达系统 HEK293 Cells
标签 C-6xHis-Avi
蛋白编号 P18627
别名 Lymphocyte activation gene 3 protein, CD223, LAG-3, Protein FDC, LAG3
氨基酸序列 Leu23-Leu450
蛋白构建 Leu23-Leu450
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 60-70 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.

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Keywords

LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated Lymphocyte activation gene 3 protein CD223 CD-223 LAG-3 CD 223 Protein FDC LAG3 LAG 3 recombinant recombinant-proteins proteins protein

 

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