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PVRIG Protein, Cynomolgus, Recombinant (His)

PVRIG Protein, Cynomolgus, Recombinant (His)

产品编号 TMPJ-00436
别名: CD112R, C7orf15MGC138295, MGC104322, transmembrane protein PVRIG, MGC138297, PVRIG, C7orf15, MGC2463

PVRIG Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 20-30 KDa and the accession number is A0A2K5WVV8.

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PVRIG Protein, Cynomolgus, Recombinant (His)
规格 价格/CNY 货期 数量
10 μg ¥ 550 5日内发货
50 μg ¥ 1,670 5日内发货
500 μg ¥ 14,200 5日内发货
1 mg ¥ 21,300 5日内发货
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产品目录号及名称: PVRIG Protein, Cynomolgus, Recombinant (His) (TMPJ-00436)
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产品描述 PVRIG Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 20-30 KDa and the accession number is A0A2K5WVV8.
种属 Cynomolgus
表达系统 HEK293 Cells
标签 C-6xHis
蛋白编号 A0A2K5WVV8
别名 CD112R, C7orf15MGC138295, MGC104322, transmembrane protein PVRIG, MGC138297, PVRIG, C7orf15, MGC2463
氨基酸序列 Thr41-Asp171
蛋白构建 Thr41-Asp171
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 20-30 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

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Keywords

PVRIG Protein, Cynomolgus, Recombinant (His) MGC-2463 CD112R MGC 2463 C7orf15MGC138295 MGC104322 MGC 138297 transmembrane protein PVRIG MGC-138297 MGC138297 PVRIG MGC-104322 MGC 104322 C7orf15MGC-138295 C7orf15 MGC2463 C7orf15MGC 138295 recombinant recombinant-proteins proteins protein

 

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