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B7-H3 Protein, Cynomolgus, Recombinant (hFc)

产品编号 TMPY-00268

B7-H3 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.8 kDa and the accession number is A0A7N9CYV2.

B7-H3 Protein, Cynomolgus, Recombinant (hFc)

产品编号 TMPY-00268

B7-H3 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.8 kDa and the accession number is A0A7N9CYV2.

规格	价格	库存	数量
50 μg	¥ 2,270	5日内发货
500 μg	¥ 14,800	5日内发货

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产品信息

生物活性	Immobilized Recombinant Cynomolgus B7-H3 / CD276 Protein (ECD, Fc Tag) at 2 μg/mL (100 μL/well) can bind Anti-B7-H3 Antibody, IgG1 Kappa , the EC50 is 9-27 ng/mL.
产品描述	B7-H3 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.8 kDa and the accession number is A0A7N9CYV2.
种属	Cynomolgus
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	A0A7N9CYV2
别名	CD276 molecule
蛋白构建	A DNA sequence encoding the cynomolgus CD276 (XP_005560056.1) (Met1-Glu465) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Leu 29
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	73.8 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy