B7-1 Protein, Mouse, Recombinant (hFc)

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SPR兼容缓冲液

产品编号 TMPY-02363

B7-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is Q00609-1.

B7-1 Protein, Mouse, Recombinant (hFc)

一键复制产品信息

SPR兼容缓冲液

产品编号 TMPY-02363

B7-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is Q00609-1.

规格	价格	库存
5 μg	¥ 237	6-8日内发货
10 μg	¥ 373	6-8日内发货
20 μg	¥ 588	5日内发货
50 μg	¥ 1,170	5日内发货
100 μg	¥ 2,260	5日内发货
200 μg	¥ 3,430	5日内发货
500 μg	¥ 7,230	5日内发货
1 mg	¥ 14,700	5日内发货

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产品信息

生物活性	1. Measured by its binding ability in a functional ELISA. 2. Immobilized human CTLA4 at 10 μg/mL (100 μl/well) can bind mouse CD80-Fc , The EC50 of mouse CD80-Fc is 28 ng/mL.
产品描述	B7-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is Q00609-1.
种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q00609-1
别名	TSA1,MIC17,Ly-53,Ly53,CD80 molecule,Cd28l,B71
蛋白构建	A DNA sequence encoding the mouse CD80 (Q00609-1) extracellular domain (Met 1-Lys 245) was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Val 38
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	50.7 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy