LAG-3 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 Cells. The accession number is Q61790.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μg | ¥ 3,820 | 期货 | |
| 100 μg | ¥ 8,830 | 期货 |
| 生物活性 | Immobilized Recombinant Mouse LAG3 Protein (His & AVI Tag), Biotinylated at 2 μg/mL (100 μL/well) on streptavidin precoated (2 μg/mL, 100 μL/well) can bind Recombinant Mouse FGL1 Protein (Fc Tag) with a linear range of 0.16-2.5 μg/mL |
| 产品描述 | LAG-3 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 Cells. The accession number is Q61790. |
| 种属 | Mouse |
| 表达系统 | HEK293 Cells |
| 标签 | C-His-Avi |
| 蛋白编号 | Q61790 |
| 别名 | Ly66,LAG-3,Lag3,CD223 |
| 蛋白构建 | A DNA sequence encoding the Mouse LAG3 (NP_032505.1)(Met1-Leu442) was expressed with a C-terminal polyhistidine tag followed by an AVI tag. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. |
| 蛋白纯度 | ≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC. |
| 分子量 | 48.5 kDa (predicted); 57.8 kDa (reducing contition) |
| 内毒素 | < 1.0 EU per μg protein as determined by the LAL method. |
| 缓冲液 | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 复溶方法 | Please refer to the lot-specific COA. |
| 存储 | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. |
| 研究背景 | LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
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