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B7-1 Protein, Human, Recombinant

产品编号 TMPY-00674

别名: CD28LG1, B7, CD80 molecule, LAB7, B7.1, B7-1, CD28LG, BB1

B7-1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.5 kDa and the accession number is A0N0P2.

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B7-1 Protein, Human, Recombinant

规格	价格/CNY		货期	数量
100 μg	￥ 4,470		现货
200 μg	￥ 7,630		5日内发货
500 μg	￥ 15,450		5日内发货

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生物活性	Testing in progress
产品描述	B7-1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.5 kDa and the accession number is A0N0P2.

种属	Human
表达系统	HEK293 Cells
标签	Tag Free
蛋白编号	A0N0P2
别名	CD28LG1, B7, CD80 molecule, LAB7, B7.1, B7-1, CD28LG, BB1
蛋白构建	The mature form of Human B7-1 (NP_005182.1) extracellular domain (Met 1-Asn 242) with five amini acids (DDDDK) at the C-terminus was expressed and purified.
蛋白纯度	> 85 % as determined by SDS-PAGE
分子量	25.5 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

1. Greenfield EA, et al. (1998) CD28/B7 costimulation: a review. Crit Rev Immunol. 18(5): 389-418. 2. Zang X, et al. (2007) The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res. 13(18 Pt 1): 5271-9. 3. Mir MA, et al. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin Ther Targets. 12(8): 969-79.

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Keywords

B7-1 Protein, Human, Recombinant LAB 7 CD28LG1 B 7 B7 CD80 molecule LAB-7 BB 1 B-7 LAB7 B7.1 B7-1 BB-1 CD28LG BB1 recombinant recombinant-proteins proteins protein

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