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B7-H3 Protein, Human, Recombinant (His), Biotinylated

产品编号 TMPY-04262

B7-H3 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48 kDa and the accession number is Q5ZPR3-1.

B7-H3 Protein, Human, Recombinant (His), Biotinylated

产品编号 TMPY-04262

B7-H3 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48 kDa and the accession number is Q5ZPR3-1.

规格	价格	库存
20 μg	¥ 1,950	In stock
100 μg	¥ 4,630	5日内发货
200 μg	¥ 7,910	5日内发货
500 μg	¥ 15,990	5日内发货

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产品信息

生物活性	Immobilized Anti-B7-H3 Antibody, IgG1 Kappa at 2 μg/mL (100 μL/well) can bind Recombinant Human CD276 / B7-H3 Protein (His Tag), Biotinylated , the EC50 is 3.6-12 ng/mL.
产品描述	B7-H3 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48 kDa and the accession number is Q5ZPR3-1.
种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q5ZPR3-1
别名	CD276 molecule,B7RP-2,B7-H3,B7H3,4Ig-B7-H3
蛋白构建	A DNA sequence encoding the human CD276 (Q5ZPR3-1) extracellular domain (Met1-Thr461) was expressed, with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro. Predicted N terminal: Leu 29
蛋白纯度	> 97 % as determined by SDS-PAGE
分子量	48 kDa (predicted); 73 kDa (reducing condition, due to glycosylation)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4, 5% trehalose, 5% mannitol. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy