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CD96 Protein, Human, Recombinant (His)

CD96 Protein, Human, Recombinant (His)

产品编号 TMPY-02011
别名: CD96 molecule, TACTILE

CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2.

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CD96 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 4,470 现货
200 μg ¥ 7,900 5日内发货
500 μg ¥ 16,710 5日内发货
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产品目录号及名称: CD96 Protein, Human, Recombinant (His) (TMPY-02011)
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生物活性
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参考文献
生物活性 Measured by its binding ability in a functional ELISA. Immobilized Human CD155/PVR hFc at 2 μg/ml (100 μl/well) can bind Human CD96 His , the EC50 of Human CD96 His is 200-800 ng/mL.

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产品描述 CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 P40200-2
别名 CD96 molecule, TACTILE
蛋白构建 The Human CD96 isoform 2 (P40200-2) extracellular domain (Met 1-Met 503) was expressed, with a polyhistidine tag at the C-terminus.
蛋白纯度 > 90 % as determined by SDS-PAGE

TargetMol

分子量 55 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. The CD155 ligand CD96 is a member of the Ig superfamily. It's an immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. NK cells recognize poliovirus receptor (PVR), a nectins and nectin-like protein family member serve to mediate cell-cell adhesion, cell migration, with the presence of an additional receptor, CD96. CD96 promotes NK cell adhesion to target cells expressing PVR, stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. The effect the cells with mutated CD96 protein lost adhesion and growth activities indicates that CD96 mutations may cause a form of the C syndrome by interfering with cell adhesion and growth.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

CD96 Protein, Human, Recombinant (His) CD96 molecule TACTILE recombinant recombinant-proteins proteins protein

 

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