Phe-Pro-Arg-PABA-Resorufin is a Chromogenic and fluorogenic peptide substrate for the highly sensitive detection of proteases in biological matrices. The substrate is also applicable to the sensitive detection of the thrombin inhibitor dabigatran in human
Pro-Adrenomedullin(153-185),human, (C143H224N42O43), a peptide with the sequence H2N-SLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL-OH, MW= 3219.6. Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaechromyctoma in 19931. AM was initially identified as a vasodilator, some have cited this as the most potent endogenous vasodilatory peptide found in the body2. Differences in opinion regarding the ability of AM to relax vascular tone arises from the differences in the model system used3. Other effects of AM include increasing the tolerance of cells to oxidative stress and hypoxic injury and angiogenesis. AM is seen as a positive influence in diseases such as hypertension, myocardial infarction, chronic obstructive pulmonary disease and other cardiovascular diseases, whereas it can be seen as a negative factor in potentiating the potential of cancerous cells to extend their blood supply and cause cell proliferation.
Tos-Gly-Pro-Arg-ANBA-IPA, a chromogenic peptide substrate, is utilized for the rapid and specific photometric assay of recombinant hirudin (r-hirudin).
c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm is a highly efficient, selective, and short-acting peptide V2 receptor agonist (V2R), with EC50s of hV2R and rV2R being 0.25 and 0.05 nM, respectively.
pGlu-Pro-Arg-MNA [N-(3-[2-Furyl]-acryloyl) - L - leucyl - glycyl - p - nitroanilide] is a chromogenic peptide substrate, specifically utilized for its role in biochemical assays.
pGlu-Pro-Arg-MNA monoacetate, a thrombin substrate modeled after a thrombin cleavage site in human fibrinogen, can be used for sensitive assays of antithrombin III activity.
Carpro-AM1 is a compound that acts as a dual inhibitor of both fatty acid amide hydrolase (FAAH) and substrate-selective cyclooxygenase (COX). It exhibits potent inhibitory activity against FAAH, with an IC50 value of 94 nM [1].