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CK1 alpha/CSNK1A1 Protein, Human, Recombinant (GST)

Synonyms: PRO2975, HLCDGP1, HEL-S-77p, CKIa, CK1a, CK1, casein kinase 1, α1, casein kinase 1, alpha 1, Casein Kinase 1 α
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26年秋季促销
26年新产品线折扣促销活动

Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are useful prognosis markers in non-small cell lung cancer (NSCLC) patients after complete resection, independent of lymph node metastasis status. CSNK1A1 can phosphorylate a large number of proteins. It participates in Wnt signaling. It phosphorylates CTNNB1 at 'Ser-45'. CSNK1A1 may play a role in segregating chromosomes during mitosis.

CK1 alpha/CSNK1A1 Protein, Human, Recombinant (GST)

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Rating icon 还可以
26年秋季促销
26年新产品线折扣促销活动
货号 TMPY-04375

别名 PRO2975, HLCDGP1, HEL-S-77p, CKIa, CK1a, CK1, casein kinase 1, α1, casein kinase 1, alpha 1, Casein Kinase 1 α

Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are useful prognosis markers in non-small cell lung cancer (NSCLC) patients after complete resection, independent of lymph node metastasis status. CSNK1A1 can phosphorylate a large number of proteins. It participates in Wnt signaling. It phosphorylates CTNNB1 at 'Ser-45'. CSNK1A1 may play a role in segregating chromosomes during mitosis.

CK1 alpha/CSNK1A1 Protein, Human, Recombinant (GST)
规格价格库存数量
5 μg
¥ 585
6-8日内发货
10 μg
¥ 958
6-8日内发货
20 μg
¥ 1,590
5日内发货
50 μg
¥ 3,170
5日内发货
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选择批次:
纯度: > 85 % as determined by SDS-PAGE
颜色: 无色透明
性状: Solution
资源下载: COA重组蛋白用户指南

产品介绍


生物活性
产品描述
Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are useful prognosis markers in non-small cell lung cancer (NSCLC) patients after complete resection, independent of lymph node metastasis status. CSNK1A1 can phosphorylate a large number of proteins. It participates in Wnt signaling. It phosphorylates CTNNB1 at 'Ser-45'. CSNK1A1 may play a role in segregating chromosomes during mitosis.
生物活性
The specific activity was determined to be 30 nmol/min/mg using casein as substrate.
研究背景
Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are useful prognosis markers in non-small cell lung cancer (NSCLC) patients after complete resection, independent of lymph node metastasis status. CSNK1A1 can phosphorylate a large number of proteins. It participates in Wnt signaling. It phosphorylates CTNNB1 at 'Ser-45'. CSNK1A1 may play a role in segregating chromosomes during mitosis.
种属
Human
表达系统
Baculovirus Insect Cells
标签
N-GST
蛋白编号P48729-1
蛋白构建
A DNA sequence encoding the full length of human CSNK1A1 isoform 1 (P48729-1) (Met 1-Phe 337) was expressed with the GST tag at the N-terminus. Predicted N terminal: Met
蛋白纯度
> 85 % as determined by SDS-PAGE
蛋白性状
Solution
缓冲液
Supplied as sterile 20 mM Tris, 500 mM NaCl, 2 mM GSH, pH 7.4.
复溶方法
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
别名
PRO2975, HLCDGP1, HEL-S-77p, CKIa, CK1a, CK1, casein kinase 1, α1, casein kinase 1, alpha 1, Casein Kinase 1 α
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量65.2 kDa (predicted); 62 kDa (reducing conditions)
储存&溶解度
运输方式Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
存储

It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

实际储存温度请以COA为准

计算器

  • 复溶 计算器
  • 重组蛋白稀释 计算器
  • 比活力 计算器

剂量转换

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技术支持

请阅读 重组蛋白用户指南 了解更多具体信息.
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