Name: Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2
Brand: TargetMol
SKU: T78436
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 mg

待询

50 mg

待询

生物活性

产品描述	Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a quenched, fluorescent MMP peptide substrate designed for the real-time quantification of MMP enzymatic activity. As an extended variant of the MMP substrate (FS-1), it demonstrates increased specificity against collagenases (MMP-1, MMP-8, MMP-13) and MT1-MMP, evidenced by higher specificity constants (Ex/Em=325 nm/400 nm). [1]
靶点活性	MMP14:7.9 μM (Km), MMP13:5.2 μM (Km), MMP1:27.5 μM (Km)
体外活性	Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2的对胶原酶(MMP-1、MMP-8、MMP-13)以及MT1-MMP (MMP-14)的特异性常数(kcat/Km)较FS-1提高了2至9倍，相对增幅约为3倍[1]。

化学信息

分子量	1221.32
分子式	C₅₅H₈₀N₁₆O₁₆
CAS No.	720710-69-0
Smiles	C(C(N[C@H](C(=O)N1[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CNC2=C(N(=O)=O)C=C(N(=O)=O)C=C2)C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)C)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)CCC1)CCCCN)=O)C=3C=4C(=CC(OC)=CC4)OC(=O)C3

储存&溶解度

存储	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.