csp

Competence-Stimulating Peptide-2 (CSP-2) is a quorum sensing signal peptide synthesized by Streptococcus pneumoniae. ComD2, a compatible receptor of CSP-2, exhibits an EC 50 value of 50.7 nM.

CSP1 is a highly potent and selective agonist of the ComD1 receptor, exhibiting an IC50 value of 10.3 nM. It represents a major variant of competence-stimulating peptide (CSP) and plays a crucial role in regulating the genetic transformation of S. pneumoniae through modulation of quorum sensing (QS). Additionally, CSP1 possesses antibacterial activity, further enhancing its potential as an effective antibacterial agent.

CSP-2503 is a 5-HT1A receptor agonist.

TTK21 是 CBP p300 组蛋白乙酰转移酶活性的激活剂，与葡萄糖基碳纳米球结合时，可通过血脑屏障，对成人大脑神经发生和长期记忆功能有益。

Itanapraced (CHF5074) 是新型γ-secretase 调节剂，能够降低 Aβ42 (IC50=3.6 nM) 和 Aβ40 (IC50=18.4 nM) 分泌。

cSPM (Cyclic spermine) 是一种 Aβ42 抑制剂。cSPM 对三种不同肽 Aβ42、胰淀素和胰岛素的聚集具有抑制作用，且能够减少细胞毒性。

CSPD substrate 是用于碱性磷酸酶的化学发光底物，提供了增强的碱性磷酸酶敏感性并简化检测过程。

Azithromycin (CP 62993) 是一种常用于细菌感染研究的大环内酯抗生素。

TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) 是一种抗朊病毒剂，可抑制蛋白酶抗性朊病毒蛋白的积累。它诱导神经鞘瘤细胞调亡，在ScN2a 和F3细胞株中均显示IC50值为3 nM。

3-Cl-DPA, a cardiac troponin activator, acts by a mechanism distinct from bepridil or TFP.

DMAC-SPP is a cleavable linker vital in ADC synthesis. DMAC-SPP joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

MC-Val-Cit-PAB-tubulysin5a is a drug-linker conjugate for ADC with potent antitumor activity by using tubulysin5a (a tubulin inhibitor), linked via the ADC linker MC-Val-Cit-PAB.

PC SPDP-NHS carbonate ester is a cleavable linker compound utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

Sulfo-DMAC-SPP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs) [1].

Sulfo-LC-SPDP is a heterobifunctional crosslinker characterized by its thiol-cleavable and membrane impermeable properties.

(Rac)-Spirotetramat-enol (Compound 8) 作为一种靶向蛋白的配体，主要用途在于合成PROTAC ACC degrader。

TC-SP 14, also known as compound 14, is a highly active and potent S1P1 agonist with oral bioavailability. It exhibits an EC50 value of 0.042 μM, indicating its strong binding affinity to the S1P1 receptor. Notably, its interaction with the S1P3 receptor is minimal, as evidenced by an EC50 value of 3.47 μM. TC-SP 14 demonstrates significant pharmacological effects, including a marked reduction in blood lymphocyte counts and the attenuation of delayed type hypersensitivity response to antigen challenge [1].

TCS PIM-1 1 (SC 204330) 是一种特异性有效的 ATP 竞争性 Pim-1 激酶抑制剂，IC50为 50 nM，对 MEK1 MEK2 和 Pim-2 表现出良好的特异性，IC50值大于 20000 nM。

GSK329 是一种有效的选择性 TNNI3 相互作用激酶 (TNNI3K) 抑制剂。 GSK329 在缺血 再灌注心脏损伤模型中表现出积极的心脏保护作用。

(Z)-SMI-4a (TCS PIM-1 4a) 是一种选择性的，细胞可渗透的且具有 ATP 竞争性的 Pim-1抑制剂，IC50为 24 μM，Ki 为 0.6 μM。它还抑制 Pim-2，IC50为 100 μM，具有抗癌活性。

DMAC-SPDB is a cleavable linker vital in ADC synthesis. DMAC-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

DMAC-SPDB-sulfo is a cleavable linker vital in ADC synthesis. DMAC-SPDB-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

TCS-PIM-1-4a (SMI-4a) 是一种泛-Pim 激酶抑制剂，可通过激活 AMPK 来阻断 mTORC1的活性。它可杀死多种髓样和淋巴样细胞系，IC50值为 0.8 μM 至 40 μM。

MC-VC-PABC-SP 141 是抗体-活性分子偶联物的一部分，由有效的 MDM2抑制剂 SP 141 和可降解的 ADC linkerMC-VC-PABC 连接而成。