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Anti-Granzyme H/GZMH Antibody (5P967)
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产品编号 TMAY-00668
别名 CTSGL2, CTLA1, CSP-C, CGL-2, CGL2, CCP-X
Anti-Granzyme H/GZMH Antibody (5P967) 是一种 Mouse 抗体，靶向 Granzyme H/GZMH。Anti-Granzyme H/GZMH Antibody (5P967) 可用于 ELISA。
Anti-Granzyme H/GZMH Antibody (5P967)
331 Anti-Granzyme H/GZMH Antibody (5P967)
还可以产品编号 TMAY-00668 别名 CTSGL2, CTLA1, CSP-C, CGL-2, CGL2, CCP-X
Anti-Granzyme H/GZMH Antibody (5P967) 是一种 Mouse 抗体，靶向 Granzyme H/GZMH。Anti-Granzyme H/GZMH Antibody (5P967) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,694 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-Granzyme H/GZMH Antibody (5P967) is a Mouse antibody targeting Granzyme H/GZMH. Anti-Granzyme H/GZMH Antibody (5P967) can be used in ELISA. |
| 别名 | CTSGL2, CTLA1, CSP-C, CGL-2, CGL2, CCP-X |
| Ig Type | Mouse IgG2a |
| 克隆号 | 5P967 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Granzyme H / GZMH (rh Granzyme H / GZMH; NP_219491.1; Met 1-Leu 246). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes (A-G and M) have been identified in the mouse, but only five are known in humans (A, B, H, M, and granzyme 3), and granzyme H appears to be specifically human. Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/natural killer (NK) compartment of the immune system. In adenovirus-infected cells in which granzyme B (gzmB) and downstream apoptosis pathways are inhibited, granzyme H directly cleaves the adenovirus DNA-binding protein (DBP), a viral component required for viral DNA replication. This virus demonstrated that gzmH directly induces an important decay in viral DNA replication. Interestingly, gzmH also cleaves the adenovirus 1K assembly protein, a major inhibitor of gzmB, and relieves gzmB inhibition. Granzyme H has a very high amino acid identity (>9%) with many portions of the granzyme B sequence, particularly near the amino terminus of the molecule despite performing a distinct enzymic function. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human Granzyme H / GZMH protein |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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