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Search Results for " mapk-2 "

Targets Recommended: Others

57

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T11241	p38 MAPK-IN-2	Others	Others
	p38 MAPK-IN-2 is an inhibitor of p38 kinase.
T16501	PF-3644022	p38 MAPK; Serine Protease; MAPK	MAPK; Proteases/Proteasome
	PF-3644022 是可口服的，具有 ATP 竞争性的MAPKAPK2 (MK2)选择性抑制剂，IC50为 5.2 nM，Ki 为 3 nM。它有效抑制 TNFα 的产生并具有抗炎作用，还抑制 MK3 和 p38 调节/激活激酶，IC50分别为 53 和 5.0 nM。
T14988	CMPD1	MAPK	MAPK
	CMPD1 是非 ATP 竞争性 p38 MAPK 介导的 MK2磷酸化选择性抑制剂(Ki:330 nM)。
T12058	MK2-IN-3 hydrate MK-2 Inhibitor III	ERK; MAPK; MNK	MAPK
	MK2-IN-3 hydrate (MK-2 Inhibitor III) 是一种口服有活性的、ATP 竞争性的MAPKAP-K2 (MK-2)选择性抑制剂(IC50:0.85 nM)。
T11898	LXH254	Raf	MAPK
	LXH254 是B/C RAF 抑制剂。
T50005	Sertaconazole	Antifungal	Microbiology/Virology
	Sertaconazole 是一种广谱抗真菌药。
T4646	TA-02	p38 MAPK; Autophagy	Autophagy; MAPK
	TA02 是一种Adezmapimod 类似物，是p38 MAPK 的抑制剂，其IC50值为 20 nM。它和Adezmapimod、SB 202190 具有相似的心源活性，可抑制 TGFBR-2。
T9034	MK2-IN-3 MK2 Inhibitor III	MAPK	MAPK
	MK2-IN-3 (MK2 Inhibitor III) 是选择性的 MAPKAP-K2 (MK-2)抑制剂(IC50:8.5 nM)，能够抑制 U937 细胞及体内 TNFα 的生成。
T4442	MK2-IN-1 hydrochloride MK2 Inhibitor,MK 25	MAPK	MAPK
	MK2-IN-1 hydrochloride (MK 25) 是一种高效的选择性 MAPKAPK2(MK2)激酶抑制剂，其 IC50值为0.11uM。
T23046	N-tert-butyl-α-Phenylnitrone (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide,N-叔丁基-α-苯基硝酮	ROS; COX	Immunology/Inflammation; Neuroscience
	N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) 是基于硝酮的自由基清除剂，可形成一氧化氮自旋加合物。它可以穿透血脑屏障，抑制 COX2的催化活性，有 ROS 清除、抗炎、神经保护、抗衰老和抗糖尿病的作用。
T8605	GS87 4-[5-[[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	GS87 是 GSK3（糖原合酶激酶 3）的高度特异性抑制剂，可诱导 AML 细胞的广泛分化。
T79572	MAPK-IN-2	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	MAPK-IN-2 (化合物3h)是一种携带抗肿瘤活性的高效MAPK抑制剂。它在多个癌细胞系中有效抑制了细胞增殖，并对MAPK途径表现出强大的抑制效果（EGFRWT IC50=281 nM, c-MET IC50=205 nM, B-RAFWT IC50=112 nM, CDK4/6 IC50=95和184 nM），对突变型EGFR和B-RAF亦展现出高效力（EGFRT790M IC50=69 nM, B-RAFV600E IC50=83 nM）。
T7276	SD 0006 SD-06,3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑	p38 MAPK; Autophagy	Autophagy; MAPK
	SD 0006 (SD-06) 是一种选择性的、ATP 竞争性的、口服有效的p38α MAPK 的二芳基吡唑抑制剂，IC50值为 110 nM。它可用于治疗关节炎。
T8656	CAY10404 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T	Apoptosis; Akt; COX	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling
	CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂，可诱导 NSC-LC 细胞凋亡，具有镇痛、抗炎和抗癌活性。
T6665	Sertaconazole nitrate FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑	Antibiotic; Antifungal	Microbiology/Virology
	Sertaconazole nitrate (FI-7045) 是一种局部广谱抗真菌药，可用于治疗浅表皮肤和粘膜感染。
T7196	HG-10-102-01 [4-[[5-氯-4-(甲基氨基)-2-嘧啶基]氨基]-3-甲氧基苯基]-4-吗啉基甲酮	LRRK2	Autophagy
	HG-10-102-01 是富含亮氨酸重复激酶 2 和突变型G2019S 抑制剂，IC50分别为20.3 nM 和3.2 nM。
T2277	Losmapimod GSK-AHAB,GW856553X,6-[5-(环丙基氨基甲酰基)-3-氟-2-甲基苯基]-N-(2,2-二甲基丙基)吡啶-3-甲酰胺,GW856553,洛批莫德,SB856553	p38 MAPK; Autophagy	Autophagy; MAPK
	Losmapimod (GSK-AHAB) 是一种可口服的特异性 p38 MAPK 抑制剂，抑制 p38α 和 p38β 的 pKi 值分别为 8.1 和 7.6。
T1764	Adezmapimod PB 203580,4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑,RWJ 64809,SB203580	Mitophagy; p38 MAPK; Autophagy	Autophagy; MAPK
	Adezmapimod (SB 203580) 是一种 p38 MAPK 抑制剂 (IC50=0.3-0.5 μM)，具有选择性和 ATP 竞争性。Adezmapimod 具有自噬和线粒体自噬的激活活性。Adezmapimod 显示出比 PKB、LCK 和 GSK-3β 高 100 倍以上的选择性。
T21312	Afatinib 阿法替尼,Afatinib free base,BIBW 2992	EGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Afatinib (BIBW 2992) 是一种不可逆的 EGFR 家族抑制剂，抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。
T1773	Afatinib Dimaleate 马来酸阿法替尼,双马来酸盐阿法替尼,BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate	EGFR; HER; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Afatinib Dimaleate (BIBW 2992MA2) 是一种可口服的苯胺基-喹唑啉衍生物和受体酪氨酸激酶表皮生长因子受体家族的抑制剂，具有抗肿瘤活性。它抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。
T64587	p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695R
	p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64587。
T64608	Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R
	Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64608。
T63119	NF-κB/MAPK-IN-1	NF-κB; MAPK	MAPK; NF-κB
	NF-κB/MAPK-IN-1 是一种有效的 NF-κB 和 MAPK 通路双重抑制剂，具有潜在的抗炎活性，抑制 NO 生成，对 LPS 诱导的iNOS，COX-2，ERΚ和P38激活有抑制作用。 NF-κB/MAPK-IN-1 可用于预防和治疗类风湿关节炎 (RA) 。
T6760	APS-2-79 hydrochloride APS-2-79 HCl,APS-2-79	MEK; MAPK	MAPK
	APS-2-79 hydrochloride (APS-2-79 HCl) 是一种 KSR 依赖性的MEK 拮抗剂，可与 ATPbiotin 竞争性地结合到 KSR2-MEK1 复合物内的KSR2。它与 KSR 结合可将 KSR 处于非活性状态，使其无法再结合 RAF 和激活 MEK，从而阻断 Ras-MAPK 信号通路。
T6934	Pexmetinib ARRY-614	Tie-2; p38 MAPK; Autophagy	Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Pexmetinib (ARRY-614) 是一种口服生物可利用的双重 p38 MAPK/Tie-2 抑制剂，可研究急性骨髓性白血病。在 HEK-293 细胞系中的 IC50 为 4 nM/18 nM。
T11224	Rineterkib ERK-IN-1	ERK; Raf	MAPK
	Rineterkib (ERK-IN-1) 是口服有效的RAF 和ERK1/2的抑制剂，与 KRAS-突变型非小细胞肺癌、BRAF-突变型非小细胞肺癌、KRAS-突变型胰腺癌、KRAS -突变型结肠癌和 KRAS-突变型卵巢癌尤为相关。
T27242	EF24 EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone	ERK; MEK; Caspase	Apoptosis; MAPK; Proteases/Proteasome
	EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) 是姜黄素类似物，口服生物利用度高，抗肿瘤作用强。它可增强活化的 Caspase3 及 Caspase9 的水平，并抑制 MEK1 及 ERK 的磷酸化形式的表达。它可以抑制口腔鳞状细胞癌细胞的 MAPK/ERK 信号通路，从而发挥抗肿瘤作用。
T22905	L748337 L-748,337	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	L748337是一种具有竞争性和高效性的 β3-肾上腺素受体拮抗剂，抑制 β3-、β2- 和 β1-肾上腺素受体发挥作用，激活 MAPK 信号传导，促进 Erk1/2 的磷酸化，抑制CL316243 的保护作用，可用于研究和β3-肾上腺素受体异常引起的疾病。
T36256	LC-2 LC 2,PROTAC KRASG12C Degrader-LC-2,LC2	PROTACs	PROTAC
	LC-2 (PROTAC KRASG12C Degrader-LC-2) 是一种新型基于von Hippel-Lindau的内源性 KRAS G12C 的 PROTAC 降解剂，DC50 在 0.25 和 0.76 μM 之间。LC-2 是一种与 MRTX849 共价结合 KRAS G12C 并招募 E3 连接酶 VH的 PROTAC，诱导 KRAS G12C 快速持续降解。LC-2 对纯合和杂合子 KRAS G12C 细胞系 MAPK 信号有抑制作用。
T4431	Olodanrigan PD-126055,EMA401	RAAS	Endocrinology/Hormones
	Olodanrigan (EMA401) 是具有口服活性、高选择性及外周受限的血管紧张素 Ⅱ 类型 2 受体(AT2R)拮抗剂。它的缓解疼痛的机制可能是：抑制增强的 AngII/AT2R 诱导的 p38 和 p42/p44 MAPK 激活，进而阻碍 DRG 神经元的过度兴奋性及 DRG 神经元的萌发。它可用于研究神经性疼痛。
T1496	Amiodarone hydrochloride 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone	Potassium Channel; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。
T16721	Ralimetinib LY2228820	Others	Others
	Ralimetinib selectively inhibits phosphorylation of MK2 (Thr334) and has no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc. Ralimetinib is an effective and selective, ATP-competitive inhibitor of p38 MAPK α/β (IC50s: 5.3 and 3.
T74374	ERK1/2 inhibitor 4
	ERK1/2 inhibitor 5 是一种有效的ERK1/2抑制剂。丝裂原活化蛋白激酶 (MAPK) 在信号转导通路中起着极其重要的作用，而细胞外信号调节激酶 (ERK) 是MAPK 家族的成员。ERK1/2 inhibitor 5 具有研究或预防癌症、炎症或其他增殖性疾病的潜力。
T60754	MAPK-IN-1
	MAPK-IN-1 (Compound 2) 是MAPK 信号通路的抑制剂，具有抗神经炎症和神经保护活性，可用于研究阿尔兹海默症。MAPK-IN-1 以23.84 μM 的IC50值抑制AChE。
T74373	ERK1/2 inhibitor 3
	ERK1/2 inhibitor 3 是一种有效的 ERK1/2抑制剂。丝裂原活化蛋白激酶 (MAPK) 在信号转导通路中起着极其重要的作用，而细胞外信号调节激酶 (ERK) 是 MAPK 家族的成员。ERK1/2 inhibitor 3 具有研究或预防癌症、炎症或其他增殖性疾病的潜力。
T81783	MK2-IN-5 Hsp25 kinase inhibitor,Mk2 pseudosubstrate	ERK	MAPK
	MK2-IN-5为Mk2的假底物，Ki值为8 μM。该化合物针对MAPK通路内的蛋白相互作用域，并能抑制HSP25与HSP27的磷酸化。
T70004	APS-2-79
	APS-2-79 是一种 KSR 依赖性的MEK 拮抗剂。APS-2-79 与 ATPbiotin 竞争性地结合到 KSR2-MEK1 复合物内的KSR2，IC50为 120 nM。APS-2-79 与 KSR 结合可将 KSR 固定在一个非活性的状态，使其无法再结合RAF 和激活MEK，从而阻断了 Ras-MAPK 信号通路。
T68459	RO4927350
	RO4927350 is a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. RO4927350 selectively blocks the MAPK pathway signaling both in vitro and in vivo, which results in significant antitumor efficacy in a broad spectrum of tumor models. RO4927350 inhibits not only ERK1/2 but also MEK1/2 phosphorylation. In cancer cells, high basal levels of phospho-MEK1/2 rather than phospho-ERK1/2 seem to correlate with greater sensitivity to RO4927350. Furthermore, RO4927350 prevents a feedback inc...
T74895	Anti-inflammatory agent 31
	Anti-inflammatory agent 31 是一种穿心莲内酯衍生物，是一种抗炎剂 (anti-inflammatoryagent)。Anti-inflammatory agent 31 通过上游阻断PI3K/Akt 和ERK1/2 MAPK 激活来抑制NF-kB 激活。Anti-inflammatory agent 31 能够恢复细胞内 GSH 水平并对肝脏具有保护作用。
T3650	STO-609 acetate	CaMK	Neuroscience
	STO-609 acetate 是选择性的、细胞可渗透的 Ca2+-钙调蛋白依赖性蛋白激酶激酶抑制剂（Ki：80/15 ng/ml，对于 CaM-KKα/KKβ）；竞争 ATP 结合位点。它比 CaMK1/2/4、PKC、MLCK、PKA 和 p42 MAPK 显示 > 80 倍的选择性。
T81598	Org OD 02-0 10-Ethenyl-19-norprogesterone	p38 MAPK	MAPK
	Org OD 02-0（10-Ethenyl-19-norprogesterone）为mPRα（膜孕酮受体α）特异性激动剂，IC50值为33.9 nM。该化合物能够激活MAPK活性，并且能抑制催乳素（PRL）的分泌。
T64147	ERK1/2 inhibitor 6
	ERK1/2 inhibitor 6 是 ERK1/2 的有效抑制剂。其中丝裂原活化蛋白激酶 (MAPK) 在信号转导通路中发挥着极大的作用，而细胞外信号调节激酶 (ERK) 是 MAPK 家族的成员。ERK1/2 inhibitor 6 对癌症、炎症或其他增殖性疾病表现出研究或预防的潜力。
T64155	ERK1/2 inhibitor 5
	ERK1/2 inhibitor 5 是一种 ERK1/2 的有效抑制剂。其中丝裂原活化蛋白激酶 (MAPK) 在信号转导通路中发挥着极大的作用，而细胞外信号调节激酶 (ERK) 是 MAPK 家族的成员。ERK1/2 inhibitor 5 具有研究或预防癌症、炎症或其他增殖性疾病的潜力。
T83740	Ziptide TFA
	Ziptide是多种丝氨酸/苏氨酸蛋白激酶的肽底物，包括MAPK激活蛋白激酶2（MAPKAPK2）、MAPKAPK3、MAPKAPK5、checkpoint kinase 1（Chk1）、AMP激活蛋白激酶（AMPK）和钙/钙调蛋白依赖型蛋白激酶II（CamKII）。它被用来评估CamKII活性以用于抑制剂的开发。
T37303	5-OxoETE 5-KETE,5-OxoETE
	5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.[1] It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM.[2] 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils via a specific G protein-coupled receptor.[3],[4],[5],[6]
T76583	H-Ile-Lys-Val-Ala-Val-OH
	H-Ile-Lys-Val-Ala-Val-OH 是层纤蛋白-1 有效的活性位点之一。H-Ile-Lys-Val-Ala-Val-OH 可促进细胞粘附、神经突生长和肿瘤生长。H-Ile-Lys-Val-Ala-Val-OH 通过激活 MAPK/ERK1/2和 PI3K/Akt 信号通路，刺激 BMMSC 细胞生长和增殖。
T37590	ML 3403
	p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively). Laufer et al (2003) Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J.Med.Chem. 46 3230 PMID:12852754 \|Kammerer et al (2007) Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-...
T61755	E6201
	E6201 (ER-806201) is a potent dual kinase inhibitor targeting MEK1 and FLT3, inhibiting their activities in an ATP-competitive manner. It effectively suppresses MEK1-induced ERK2 phosphorylation (IC50 = 5.2 nM), MKK4-induced JNK phosphorylation (IC50 = 91 nM), and MKK6-induced p38 MAPK phosphorylation (IC50 = 19 nM). E6201 exhibits anti-tumor and anti-psoriasis effects [1] [2].
T36012	p38α inhibitor 2
	p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets[1]. [1]. Raubo P, et al. The discovery and evaluation of 3-amino-2(1H)-pyrazinones as a novel series of selective p38α MAP kinase inhibitors [published online ahead of pr...
T36676	Rineterkib hydrochloride
	Rineterkib hydrochloride (compound B) is an orally active RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer[1]. ERK-IN-1 (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the C...

化合物

p38 MAPK-IN-2

Cat.No: T11241

Target: Others

Cat.No: T16501

Target: p38 MAPK, Serine Protease, MAPK

Cat.No: T14988

Target: MAPK

MK2-IN-3 hydrate

Cat.No: T12058

Synonym: MK-2 Inhibitor III

Target: ERK, MAPK, MNK

Cat.No: T11898

Target: Raf

Cat.No: T50005

Target: Antifungal

Cat.No: T4646

Target: p38 MAPK, Autophagy

Cat.No: T9034

Synonym: MK2 Inhibitor III

Target: MAPK

MK2-IN-1 hydrochloride

Cat.No: T4442

Synonym: MK2 Inhibitor,MK 25

Target: MAPK

N-tert-butyl-α-Phenylnitrone

Cat.No: T23046

Synonym: (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide,N-叔丁基-α-苯基硝酮

Target: ROS, COX

Cat.No: T8605

Synonym: 4-[5-[[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine

Target: GSK-3

Cat.No: T79572

Target: EGFR

Cat.No: T7276

Synonym: SD-06,3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑

Target: p38 MAPK, Autophagy

Cat.No: T8656

Synonym: 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T

Target: Apoptosis, Akt, COX

Sertaconazole nitrate

Cat.No: T6665

Synonym: FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑

Target: Antibiotic, Antifungal

Cat.No: T7196

Synonym: [4-[[5-氯-4-(甲基氨基)-2-嘧啶基]氨基]-3-甲氧基苯基]-4-吗啉基甲酮

Target: LRRK2

Cat.No: T2277

Synonym: GSK-AHAB,GW856553X,6-[5-(环丙基氨基甲酰基)-3-氟-2-甲基苯基]-N-(2,2-二甲基丙基)吡啶-3-甲酰胺,GW856553,洛批莫德,SB856553

Target: p38 MAPK, Autophagy

Cat.No: T1764

Synonym: PB 203580,4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑,RWJ 64809,SB203580

Target: Mitophagy, p38 MAPK, Autophagy

Cat.No: T21312

Synonym: 阿法替尼,Afatinib free base,BIBW 2992

Target: EGFR, Autophagy

Afatinib Dimaleate

Cat.No: T1773

Synonym: 马来酸阿法替尼,双马来酸盐阿法替尼,BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate

Target: EGFR, HER, Autophagy

p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695R

Cat.No: T64587

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R

Cat.No: T64608

NF-κB/MAPK-IN-1

Cat.No: T63119

Target: NF-κB, MAPK

APS-2-79 hydrochloride

Cat.No: T6760

Synonym: APS-2-79 HCl,APS-2-79

Target: MEK, MAPK

Cat.No: T6934

Synonym: ARRY-614

Target: Tie-2, p38 MAPK, Autophagy

Cat.No: T11224

Synonym: ERK-IN-1

Target: ERK, Raf

Cat.No: T27242

Synonym: EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone

Target: ERK, MEK, Caspase

Cat.No: T22905

Synonym: L-748,337

Target: Adrenergic Receptor

Cat.No: T36256

Synonym: LC 2,PROTAC KRASG12C Degrader-LC-2,LC2

Target: PROTACs

Cat.No: T4431

Synonym: PD-126055,EMA401

Target: RAAS

Amiodarone hydrochloride

Cat.No: T1496

Synonym: 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone

Target: Potassium Channel, Adrenergic Receptor, Autophagy

Cat.No: T16721

Synonym: LY2228820

Target: Others

ERK1/2 inhibitor 4

Cat.No: T74374

Cat.No: T60754

ERK1/2 inhibitor 3

Cat.No: T74373

Cat.No: T81783

Synonym: Hsp25 kinase inhibitor,Mk2 pseudosubstrate

Target: ERK

Cat.No: T70004

Cat.No: T68459

Anti-inflammatory agent 31

Cat.No: T74895

STO-609 acetate

Cat.No: T3650

Target: CaMK

Cat.No: T81598

Synonym: 10-Ethenyl-19-norprogesterone

Target: p38 MAPK

ERK1/2 inhibitor 6

Cat.No: T64147

ERK1/2 inhibitor 5

Cat.No: T64155

Cat.No: T83740

Cat.No: T37303

Synonym: 5-KETE,5-OxoETE

H-Ile-Lys-Val-Ala-Val-OH

Cat.No: T76583

Cat.No: T37590

Cat.No: T61755

p38α inhibitor 2

Cat.No: T36012

Rineterkib hydrochloride

Cat.No: T36676

Cat. No.	Product Name	Target	Signaling Pathways
T5S2358	Dehydrocorydaline Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine	BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
	Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax，Bcl-2蛋白表达，激活caspase-7，caspase-8，并使PARP 失活。它能增强p38 MAPK 活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。
T5S0761	Nitidine chloride	Apoptosis; ERK; FAK; p38 MAPK; NF-κB; Topoisomerase; STAT; Parasite	Angiogenesis; Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。
T10990	Dehydrocorydaline chloride 盐酸脱氢紫堇碱,13-Methylpalmatine chloride	BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
	Dehydrocorydaline chloride (13-Methylpalmatine chloride) 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达；激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。
T2S2362	Dehydrocorydaline nitrate 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱	BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
	Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达，激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌、抗疟疾等功效。
T6427	Butein 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因	Apoptosis; EGFR; Others; PDE; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Others; Tyrosine Kinase/Adaptors
	Butein (2’,3,4,4’-tetrahydroxy Chalcone) 是一种 cAMP 特异性PDE 抑制剂，也是蛋白酪氨酸激酶抑制剂，还是一种SIRT1激活剂。它通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。
T5429	Theaflavin 3,3'-digallate 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG	Virus Protease; Antioxidant; HIV Protease; HSV	Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
	Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂，IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制，可抑制 gp41 和 NS2B-3 蛋白酶的活性，并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚，有抗肿瘤作用。
T4085	Paris saponin VII 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位，增加凋亡相关蛋白的表达，并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬，可研究白血病。
T5729	L-quebrachitol L-白雀木醇,(-)-白雀木醇	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	L-Quebrachitol 是一种从多种植物中分离得到的天然产物，能够触发 BMP-2 反应以及 Runx2、MAPK 和 Wnt/β-catenin 信号通路，诱导成骨细胞生成。
T5S2283	Sesamolin	p38 MAPK; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Sesaminol 是从Justicia orbiculata 中分离得到的一种天然产物，抑制脂质过氧化，具有神经保护作用和抗氧化活性。它通过抑制JNK、p38 MAPKs 和caspase-3磷酸化，抑制MAPK 的级联反应。
T4912	Jatrorrhizine chloride 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride	Others; 5-HT Receptor; OCT; Antibacterial; AChE	GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	Jatrorrhizine chloride (Neprotine chloride) 是从黄连中分离得到的生物碱，具有神经保护、抗菌、抗氧化和抗疟原虫活性。它通过抑制摄取2转运蛋白的活性减少血清素和去甲肾上腺素的摄取。它是具有口服活性的乙酰胆碱酯酶抑制剂。
T2S2382	3'-Hydroxypterostilbene 3’-羟基紫檀茋,3'-羟基紫檀茋,3'-HPT	Apoptosis; Autophagy	Apoptosis; Autophagy
	3'-Hydroxypterostilbene (3'-HPT) 是天然紫檀芪类似物，通过诱导细胞凋亡和自噬，有效抑制人结肠癌细胞的生长。它抑制 PI3K/Akt/mTOR/p70S6K 和 p38MAPK 途径并激活 ERK1/2，JNK1/2 MAPK 途径。
T5S1058	Triptonide 雷公藤内酯酮,PG 492,NSC 165677	Apoptosis; Wnt/beta-catenin; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Stem Cells
	Triptonide (PG 492) 是从雷公藤中鉴定出的一种天然产物，是一种 Wnt 信号抑制剂，其 IC50约为 0.3 nM。它具有免疫抑制、抗炎、避育、神经保护和抗淋巴瘤作用。
T3008	Lawsone methyl ether 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌	Apoptosis; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology
	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和Swertia calycina 中分离出的，有抗真菌和抗菌活性。
T3924	Astragaloside II 黄芪皂苷 II,Astrasieversianin VIII	TGF-beta/Smad	Stem Cells
	Astragaloside II (Astrasieversianin VIII) 是一种分离自黄芪中的天然化合物。
T6S0095	Genkwanin 7-O-Methylapigenin,Puddumetin,Apigenin 7-methyl ether,芫花素	Virus Protease	Microbiology/Virology
	Genkwanin (Apigenin 7-methyl ether) 是一种O-甲基化黄酮，有抗炎活性，通过被动扩散和多药耐药蛋白介导的外排机制转运。
T3410	Momordin Ic 地肤子皂苷Ic,地肤子皂苷 Ic,Momordin 1c	Apoptosis; MAPK; PI3K	Apoptosis; MAPK; PI3K/Akt/mTOR signaling
	Momordin Ic (Momordin 1c) 是山茱萸的主要皂苷成分，通过氧化应激调控线粒体功能障碍诱导细胞凋亡，具有抗癌活性。
T3763	Fumaric acid Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,反丁烯二酸,Donitic acid,Allomaleic acid,富马酸	Endogenous Metabolite	Metabolism
	Fumaric acid (2-Butenedioic acid) 与烟酸酶缺乏症相关，是癌症相关的内源性代谢物。
TN1013	Cucurbitacin D	Apoptosis	Apoptosis
	Cucurbitacin D 是一种从 Ecballium elaterium （L.）分离出来的三萜类化合物，具有抗癌抗肿瘤活性，抑制转移性 PrC 中的葡萄糖摄取和乳酸产生，诱导独立于 ERK1/2 激活的炎症小体激活。 Cucurbitacin D 是巨噬细胞中的一种新的炎症小体激活剂，通过调节 JAK/STAT3、PI3K/Akt/mTOR 和 MAPK 信号通路抑制 HepG2 细胞增殖并诱导细胞凋亡，可用于研究宫颈癌、白血病和前列腺癌。
T7033	Rosmanol	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rosmanol 能够显著抑制脂多糖诱导的 INOS、COX-2 的表达，抑制低密度脂蛋白的氧化，并具有抗炎作用。
TN5888	Toddaculin	Others	Others
	Toddaculin 是一种天然香豆素，抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡，具有抗炎活性。
T6S1369	Vitexin 牡荆素,Apigenin-8-C-glucoside	Antioxidant	oxidation-reduction
	Vitexin 是一种存在于多种药用植物（如榕树、螺旋藻）中的 c-糖基化的黄酮。它具有广泛的药理作用，包括抗氧化，抗癌，抗炎，抗痛觉过敏和神经保护作用。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。
T2S0618	β-Elemonic Acid 3-oxo Tirucallic Acid,β-岚香酮酸,Beta-Elemonic acid,3-Oxotirucallenoic Acid,β-榄香酮酸,Elemadienonic Acid	Apoptosis; Reactive Oxygen Species; COX	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	β-Elemonic Acid (3-Oxotirucallenoic Acid) 是从乳香树中分离得到的一种三萜，具有抗癌和抗炎作用。它抑制脯氨酰内肽酶，诱导细胞凋亡，活性氧和COX-2表达。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T6S0735	Flavokawain B 黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone	Apoptosis; Others	Apoptosis; Others
	Flavokawain B (Flavokavain B) 是从卡瓦醉椒的根提取物中，分离出的查尔酮。它是一种凋亡诱导剂，可抑制各种癌细胞株生长。它以极低的无毒浓度抑制人脑内皮细胞的迁移和血管形成，具有抗血管生成活性。
T3923	Calycosin Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮	Apoptosis; Tyrosinase	Apoptosis; Proteases/Proteasome
	Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。
T6S1538	Neochlorogenic acid 新绿原酸,trans-5-O-Caffeoylquinic acid,Neochlorogenate,金银花,5-O-Caffeoylquinic acid	TNF; NF-κB; COX; Antibacterial; Interleukin	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) 是在干果和其他植物中发现的一种多酚类天然产物，可抑制iNOS 和COX-2蛋白表达，抑制TNF-α和IL-1β产生，还抑制磷酸化的NF-κB p65和p38 MAPK 活化。
T3S1416	Decursin Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素	Apoptosis; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling
	Decursin (Decursinol angelate) 是一种细胞毒性剂，是一种来自朝鲜当归根的有效蛋白激酶 C 激活剂。它通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。它通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长，迁移和侵袭。
T5S0754	Isoquercetin 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷	NF-κB; Wnt/beta-catenin; NO Synthase	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; Stem Cells
	Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚，具有抗氧化，抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性，氧化应激和炎症反应。它具有高生物利用度和低毒性，是预防糖尿病妊娠出生缺陷的有希望的候选药物。
T6S1684	8-Gingerol	Antioxidant; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction
	8-Gingerol 分离自姜的根状茎，是口服有效的 TRPV1激活剂，EC50值为5.0 µM。8-Gingerol 抑制 COX-2，还能抑制体外 H. pylori 的生长。
T6S1572	Sauchinone	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。
T3669	Curcumenol (+)-Curcumenol,莪术醇	P450	Metabolism
	Curcumenol ((+)-Curcumenol) 提取具有药用价值的 Curcuma zedoaria，是高效的 CYP3A4抑制剂(IC50=12.6 μM)，具有神经抗肿瘤、保护、抗炎、和保肝的作用。它在 LPS 刺激的 BV-2 小胶质细胞中，抑制 Akt 介导的 NF-κB 活化及 p38 MAPK 信号通路。
T6S1256	Ruscogenin	NOS; NF-κB; NOD-like Receptor (NLR)	Immunology/Inflammation; NF-κB
	Ruscogenin 是一种重要甾体皂苷元，提取自麦冬。它能够抑制 TXNIP/NLRP3炎症体激活和 MAPK 途径，改善脑缺血诱导的血脑屏障功能障碍，具有显著抗血栓、抗炎作用。
T4S2326	Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside	ERK; p38 MAPK; NF-κB; JNK	MAPK; NF-κB
	Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷，可用于炎症疾病的研究和促进血液循环。它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应，用于炎性过敏性疾病中的潜能。
TN2039	Panaxydol	cAMP; p38 MAPK; JNK	GPCR/G Protein; MAPK
	Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through NADPH oxidase and mitochondria.
T80631	Esculin sesquihydrate	p38 MAPK	MAPK
	Esculin sesquihydrate为荧光香豆素葡萄糖苷类化合物，源自灰树皮有效成分。该化合物可经MAPK信号通路改善实验性糖尿病肾病(DN)的认知障碍，并具有抗氧化应激及抗炎效应。
T4S0083	Protostemonine	Others	Others
	Protostemonine 是一种主要从 Stemona sesslifolia 根中分离得到的生物碱，对哮喘及革兰氏阴性菌所致急性肺损伤有抗炎作用。
TN5050	Sprengerinin C	NADPH-oxidase; VEGFR; p38 MAPK; ROS; Akt; PI3K; mTOR; p53	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascul

天然产物

Dehydrocorydaline

Cat.No: T5S2358

Synonym: Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Nitidine chloride

Cat.No: T5S0761

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Dehydrocorydaline chloride

Cat.No: T10990

Synonym: 盐酸脱氢紫堇碱,13-Methylpalmatine chloride

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Dehydrocorydaline nitrate

Cat.No: T2S2362

Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Cat.No: T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因

Target: Apoptosis, EGFR, Others, PDE, Autophagy

Theaflavin 3,3'-digallate

Cat.No: T5429

Synonym: 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG

Target: Virus Protease, Antioxidant, HIV Protease, HSV

Paris saponin VII

Cat.No: T4085

Synonym: 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Cat.No: T5729

Synonym: L-白雀木醇,(-)-白雀木醇

Target: Wnt/beta-catenin

Cat.No: T5S2283

Target: p38 MAPK, Caspase, JNK

Jatrorrhizine chloride

Cat.No: T4912

Synonym: 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride

Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE

3'-Hydroxypterostilbene

Cat.No: T2S2382

Synonym: 3’-羟基紫檀茋,3'-羟基紫檀茋,3'-HPT

Target: Apoptosis, Autophagy

Cat.No: T5S1058

Synonym: 雷公藤内酯酮,PG 492,NSC 165677

Target: Apoptosis, Wnt/beta-catenin, Autophagy

Lawsone methyl ether

Cat.No: T3008

Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌

Target: Apoptosis, Antibacterial, Antifungal

Astragaloside II

Cat.No: T3924

Synonym: 黄芪皂苷 II,Astrasieversianin VIII

Target: TGF-beta/Smad

Cat.No: T6S0095

Synonym: 7-O-Methylapigenin,Puddumetin,Apigenin 7-methyl ether,芫花素

Target: Virus Protease

Cat.No: T3410

Synonym: 地肤子皂苷Ic,地肤子皂苷 Ic,Momordin 1c

Target: Apoptosis, MAPK, PI3K

Cat.No: T3763

Synonym: Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,反丁烯二酸,Donitic acid,Allomaleic acid,富马酸

Target: Endogenous Metabolite

Cat.No: TN1013

Target: Apoptosis

Cat.No: T7033

Target: Antioxidant, COX

Cat.No: TN5888

Target: Others

Cat.No: T6S1369

Synonym: 牡荆素,Apigenin-8-C-glucoside

Target: Antioxidant

Cat.No: T6S1699

Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Target: Lipoxygenase, Autophagy

β-Elemonic Acid

Cat.No: T2S0618

Synonym: 3-oxo Tirucallic Acid,β-岚香酮酸,Beta-Elemonic acid,3-Oxotirucallenoic Acid,β-榄香酮酸,Elemadienonic Acid

Target: Apoptosis, Reactive Oxygen Species, COX

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Cat.No: T6S0735

Synonym: 黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone

Target: Apoptosis, Others

Cat.No: T3923

Synonym: Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮

Target: Apoptosis, Tyrosinase

Neochlorogenic acid

Cat.No: T6S1538

Synonym: 新绿原酸,trans-5-O-Caffeoylquinic acid,Neochlorogenate,金银花,5-O-Caffeoylquinic acid

Target: TNF, NF-κB, COX, Antibacterial, Interleukin

Cat.No: T3S1416

Synonym: Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素

Target: Apoptosis, PKC

Cat.No: T5S0754

Synonym: 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷

Target: NF-κB, Wnt/beta-catenin, NO Synthase

Cat.No: T6S1684

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

Cat.No: T6S1572

Target: ERK, p38 MAPK, NF-κB

Cat.No: T3669

Synonym: (+)-Curcumenol,莪术醇

Target: P450

Cat.No: T6S1256

Target: NOS, NF-κB, NOD-like Receptor (NLR)

Cat.No: T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Cat.No: TN2039

Target: cAMP, p38 MAPK, JNK

Esculin sesquihydrate

Cat.No: T80631

Target: p38 MAPK

Cat.No: T4S0083

Target: Others

Cat.No: TN5050

Target: NADPH-oxidase, VEGFR, p38 MAPK, ROS, Akt, PI3K, mTOR, p53

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04539	ERK2 Protein, Human, Recombinant (GST) ERT1,ERK,PRKM1,ERK-2,p41,p41mapk,PRKM2...	Human	Baculovirus Insect Cells
	ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 67 kDa and the accession number is P28482-1.
TMPY-02252	LAMTOR2 Protein, Human, Recombinant (His) Ragulator2,p14,MAPBPIP,MAPKSP1AP,RP11-336K...	Human	E. coli
	Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, Roadblock domain-containing protein 3, LAMTOR2, MAPBPIP, and ROBLD3, is a protein which belongs to the GAMAD family. LAMTOR2 / ROBLD3 is a regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factor...
TMPY-04571	ERK2 Protein, Mouse, Recombinant (His & GST) PRKM2,C78273,mitogen-activated protein kin...	Mouse	Baculovirus Insect Cells
	ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.1 kDa and the accession number is P63085.
TMPY-04412	Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST) mitogen-activated protein kinase kinase kinase kinase 2<...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein, and MAP4K2, is cytoplasm and peripheral membrane protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. MAP4K2 contains one CNH domain and one protein kinase domain. Although this kinase is found in many tissues, its express...
TMPY-02595	DUSP14 Protein, Human, Recombinant (His & MBP) MKP6,MKP-L,dual specificity phosphatase 14	Human	E. coli
	Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (...
TMPY-02519	BLVRB Protein, Human, Recombinant (His) HEL-S-10,biliverdin reductase B,FLR,BVRB,SDR43U1	Human	E. coli
	Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step i...
TMPJ-01315	IL-1RL2 Protein, Mouse, Recombinant (His) Interleukin-1 receptor-like 2,IL1RL2,IL-36...	Mouse	HEK293 Cells
	Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene, belongs to the interleukin-1 receptor family.IL1RL2 is the receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. IL-1RL2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His)	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...
TMPJ-01050	GRB2 Protein, Human, Recombinant (His) Growth Factor Receptor-Bound Protein 2,SH2...	Human	E. coli
	As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted acti...
TMPJ-01314	IL-1RL2 Protein, Mouse, Recombinant (hFc) IL-36R,IL-36 receptor,IL-1Rrp2,IL1R-rp2,IL...	Mouse	HEK293 Cells
	Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene, belongs to the interleukin-1 receptor family.IL1RL2 is the receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. IL-1RL2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc ta...
TMPY-04544	MEK2 Protein, Human, Recombinant (GST) mitogen-activated protein kinase kinase 2,FLJ2<...	Human	Baculovirus Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ...
TMPY-04466	STK40 Protein, Human, Recombinant (His & GST) SHIK,SgK495,serine/threonine kinase 40	Human	Baculovirus Insect Cells
	STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs. Interestingly, cells overexpressing Stk40 exclusively contribute to the ExEn layer of chimeric embryos when injected into host blastocysts. In contrast, deletion of Stk40 in ES...
TMPY-02029	CDO Protein, Human, Recombinant (His) CDON1,HPE11,cell adhesion associated, oncogene regulated,CDO...	Human	HEK293 Cells
	Cell adhesion molecule-related, down-regulated by oncogenes (CDON), also known as CDO, is an Ig superfamily member, is a component of a cell surface receptor that positively regulates skeletal myogenesis. Brother of CDO (BOC) is a cell surface receptor that derives its name from the structurally related protein, CDON. They are components of a cell surface receptor that positively regulates myogenesis in vitro. Expression of Cdo and Boc in myoblast cell lines is downregulated by the ras oncogene,...
TMPY-04392	RSK3 Protein, Human, Recombinant (GST) HU-2,ribosomal protein S6 kinase, 90kDa, polypeptid...	Human	Baculovirus Insect Cells
	Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 a...
TMPY-01442	DMBT1 Protein, Human, Recombinant (His) GP340,deleted in malignant brain tumors 1,muclin	Human	HEK293 Cells
	Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo...
TMPJ-00850	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) Protein T1,suppression of tumorigenicity 2,Ly84,DER...	Mouse	HEK293 Cells
	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2.
TMPY-00891	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) neuropilin 1,VEGF165R,CD304,NP1,Neuropilin-1,NRP,BDCA4	Human	HEK293 Cells
	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2.
TMPY-02011	CD96 Protein, Human, Recombinant (His) CD96 molecule,TACTILE	Human	HEK293 Cells
	CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2.
TMPY-04113	KRAS Protein,Human,Recombinant(G12D & Q61H, His) Kirsten rat sarcoma viral oncogene homolog,KRAS2,KI...	Human	E. coli
	KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
TMPY-01613	Periostin/OSF-2 Protein, Mouse, Recombinant (His) A630052E07Rik,OSF-2,Osf2,PLF,AI74...	Mouse	HEK293 Cells
	Periostin/OSF-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 89 kDa and the accession number is Q62009-2.
TMPY-01717	VEGF164 Protein, Mouse, Recombinant vascular endothelial growth factor A,Vpf,Vegf,血管内皮生长因子	Mouse	Baculovirus Insect Cells
	VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2.
TMPY-02096	TACI Protein, Human, Recombinant (His) RYZN,IGAD2,CVID,TACI,TNFRSF14B,CVID2,tumor...	Human	HEK293 Cells
	TACI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is O14836-2.
TMPY-00341	FGFR3 Protein, Human, Recombinant (alpha IIIb, His) CEK2,HSFGFR3EX,fibroblast growth factor receptor 3,...	Human	HEK293 Cells
	FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2.
TMPY-06056	KRAS Protein, Human, Recombinant (G12D, His) KRAS1,K-RAS4B,Kirsten rat sarcoma viral oncogene homolog,RAL...	Human	E. coli
	KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2.
TMPY-00751	TrkB Protein, Human, Recombinant (His) trk-B,GP145-TrkB/GP95-TrkB,neurotrophic tyrosine kinase, rec...	Human	HEK293 Cells
	TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.
TMPY-01691	Clusterin Protein, Human, Recombinant (CLU34, His) SGP-2,AAG4,KUB1,CLI,CLU2,TRPM2,AP...	Human	HEK293 Cells
	Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2.
TMPY-04844	BTN3A1 Protein, Human, Recombinant (His) BTN3.1,butyrophilin subfamily 3 member A1,BTF5,BT3.1,CD2...	Human	HEK293 Cells
	BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2.
TMPY-05288	PLGF/PGF Protein, Human, Recombinant (aa 19-149) PLGF,PGFL,placental growth factor,D12S1900,SHGC-107...	Human	E. coli
	PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P49763-2.
TMPY-02820	SDF-1 Protein, Human, Recombinant (isoform a) SDF1,chemokine (C-X-C motif) ligand 12,IRH,SCYB1	Human	E. coli
	SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2.
TMPY-01935	c-Kit Protein, Human, Recombinant (His) PBT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog...	Human	HEK293 Cells
	c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2.
TMPY-04356	GSK3B Protein, Human, Recombinant (His) glycogen synthase kinase 3 beta,glycogen synthase kinase 3 β	Human	Baculovirus Insect Cells
	GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2.
TMPY-02500	YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) Gp39,AW208766,Brp39,chitinase 3 like 1	Mouse	HEK293 Cells
	YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is Q61362-2.
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST) v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k...	Human	Baculovirus Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an...
TMPY-01985	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated FCGR2,FCGR21,CD32A,FCG2,...	Human	HEK293 Cells
	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2.
TMPY-04644	PDGFB Protein, Human, Recombinant (His) platelet-derived growth factor beta polypeptide,SSV,c-sis,SI...	Human	P. pastoris (Yeast)
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted...
TMPY-05414	NKG2D/CD314 Protein, Mouse, Recombinant (hFc) D6H12S2489E,NKG2-D,killer cell le...	Mouse	Baculovirus Insect Cells
	NKG2D/CD314 Protein, Mouse, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is O54709-2.
TMPY-01871	IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) interleukin 5 receptor, alpha,IL5R,CD125,CDw12<...	Human	HEK293 Cells
	IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2.
TMPY-02792	GDNF Protein, Human, Recombinant (HEK293) HSCR3,ATF2,HFB1-GDNF,ATF1,glial cell derived neurot...	Human	HEK293 Cells
	GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
TMPY-01888	KRAS Protein,Human, Recombinant (Q61H, His) KRAS2,C-K-RAS,Kirsten rat sarcoma viral oncogene ho...	Human	E. coli
	KRAS Protein,Human, Recombinant (Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P01116-2.
TMPY-01359	ST2/IL-1 RL1 Protein, Human, Recombinant (His) IL1RL1,IL‑1 R4,DER4,ST2,IL33R,interleukin 1 recepto...	Human	HEK293 Cells
	ST2/IL-1 RL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q01638-2.
TMPY-00747	Nectin-2 Protein, Human, Recombinant (His) PVRR2,Nectin-2,poliovirus receptor-related...	Human	HEK293 Cells
	Nectin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
TMPY-05427	CD19 Protein, Human, Recombinant (hFc) CVID3,B4,CD19 molecule	Human	HEK293 Cells
	CD19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is P15391-2.
TMPJ-00335	TGFBR2 Protein, Mouse, Recombinant (His) TGFR-2,TGF-beta type II receptor,Transforming growt...	Mouse	HEK293 Cells
	TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.
TMPY-04051	c-Kit Protein, Human, Recombinant (hFc) SCFR,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene h...	Human	HEK293 Cells
	c-Kit Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is P10721-2.
TMPY-01033	IL-32 Protein, Human, Recombinant (isoform alpha, His) IL-32δ,IL-32beta,IL32,TAIFc,IL-3<...	Human	HEK293 Cells
	IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,...
TMPY-02172	Midkine Protein, Human, Recombinant midkine (neurite growth-promoting factor 2),NEGF	Human	Baculovirus Insect Cells
	Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angio...
TMPY-00005	FGF-8a Protein, Human, Recombinant fibroblast growth factor 8 (androgen-induced),FGF-8,AIGF,NEW...	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac...
TMPY-03425	Tau Protein, Human, Recombinant (His) PPND,FTDP-17,MTBT1,DDPAC,MAPTL,MTBT2,microtubule-as...	Human	E. coli
	MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP...
TMPY-01199	CD74 Protein, Human, Recombinant (His) II,DHLAG,Ia-GAMMA,CD74 molecule, major histocompatibility co...	Human	HEK293 Cells
	CD74 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is P04233-2.
TMPY-05586	CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated TMIGD2,IGPR-1,transmembrane and immunoglobulin doma...	Human	HEK293 Cells
	The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent in mouse and rat genomes. The immunoglobulin domain of IGPR-1 was predicted to be Ig V (variable) fold and was found to be highly similar to the Ig domain of myelin-associated glycoprotein.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy. CD28H/TMIGD2 Protein, Hu...
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重组蛋白

ERK2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04539

Species: Human

Expression System: Baculovirus Insect Cells

LAMTOR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02252

Species: Human

Expression System: E. coli

ERK2 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04571

Species: Mouse

Expression System: Baculovirus Insect Cells

Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04412

Species: Human

Expression System: Baculovirus Insect Cells

DUSP14 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPY-02595

Species: Human

Expression System: E. coli

BLVRB Protein, Human, Recombinant (His)

Cat.No: TMPY-02519

Species: Human

Expression System: E. coli

IL-1RL2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01315

Species: Mouse

Expression System: HEK293 Cells

MAPK3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01692

Species: Human

Expression System: E. coli

GRB2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01050

Species: Human

Expression System: E. coli

IL-1RL2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01314

Species: Mouse

Expression System: HEK293 Cells

MEK2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04544

Species: Human

Expression System: Baculovirus Insect Cells

STK40 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04466

Species: Human

Expression System: Baculovirus Insect Cells

CDO Protein, Human, Recombinant (His)

Cat.No: TMPY-02029

Species: Human

Expression System: HEK293 Cells

RSK3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04392

Species: Human

Expression System: Baculovirus Insect Cells

DMBT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01442

Species: Human

Expression System: HEK293 Cells

ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)

Cat.No: TMPJ-00850

Species: Mouse

Expression System: HEK293 Cells

Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)

Cat.No: TMPY-00891

Species: Human

Expression System: HEK293 Cells

CD96 Protein, Human, Recombinant (His)

Cat.No: TMPY-02011

Species: Human

Expression System: HEK293 Cells

KRAS Protein,Human,Recombinant(G12D & Q61H, His)

Cat.No: TMPY-04113

Species: Human

Expression System: E. coli

Periostin/OSF-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01613

Species: Mouse

Expression System: HEK293 Cells

VEGF164 Protein, Mouse, Recombinant

Cat.No: TMPY-01717

Species: Mouse

Expression System: Baculovirus Insect Cells

TACI Protein, Human, Recombinant (His)

Cat.No: TMPY-02096

Species: Human

Expression System: HEK293 Cells

FGFR3 Protein, Human, Recombinant (alpha IIIb, His)

Cat.No: TMPY-00341

Species: Human

Expression System: HEK293 Cells

KRAS Protein, Human, Recombinant (G12D, His)

Cat.No: TMPY-06056

Species: Human

Expression System: E. coli

TrkB Protein, Human, Recombinant (His)

Cat.No: TMPY-00751

Species: Human

Expression System: HEK293 Cells

Clusterin Protein, Human, Recombinant (CLU34, His)

Cat.No: TMPY-01691

Species: Human

Expression System: HEK293 Cells

BTN3A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04844

Species: Human

Expression System: HEK293 Cells

PLGF/PGF Protein, Human, Recombinant (aa 19-149)

Cat.No: TMPY-05288

Species: Human

Expression System: E. coli

SDF-1 Protein, Human, Recombinant (isoform a)

Cat.No: TMPY-02820

Species: Human

Expression System: E. coli

c-Kit Protein, Human, Recombinant (His)

Cat.No: TMPY-01935

Species: Human

Expression System: HEK293 Cells

GSK3B Protein, Human, Recombinant (His)

Cat.No: TMPY-04356

Species: Human

Expression System: Baculovirus Insect Cells

YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02500

Species: Mouse

Expression System: HEK293 Cells

C-ABL/ABL1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04396

Species: Human

Expression System: Baculovirus Insect Cells

CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-01985

Species: Human

Expression System: HEK293 Cells

PDGFB Protein, Human, Recombinant (His)

Cat.No: TMPY-04644

Species: Human

Expression System: P. pastoris (Yeast)

NKG2D/CD314 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-05414

Species: Mouse

Expression System: Baculovirus Insect Cells

IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)

Cat.No: TMPY-01871

Species: Human

Expression System: HEK293 Cells

GDNF Protein, Human, Recombinant (HEK293)

Cat.No: TMPY-02792

Species: Human

Expression System: HEK293 Cells

KRAS Protein,Human, Recombinant (Q61H, His)

Cat.No: TMPY-01888

Species: Human

Expression System: E. coli

ST2/IL-1 RL1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01359

Species: Human

Expression System: HEK293 Cells

Nectin-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00747

Species: Human

Expression System: HEK293 Cells

CD19 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05427

Species: Human

Expression System: HEK293 Cells

TGFBR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00335

Species: Mouse

Expression System: HEK293 Cells

c-Kit Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04051

Species: Human

Expression System: HEK293 Cells

IL-32 Protein, Human, Recombinant (isoform alpha, His)

Cat.No: TMPY-01033

Species: Human

Expression System: HEK293 Cells

Midkine Protein, Human, Recombinant

Cat.No: TMPY-02172

Species: Human

Expression System: Baculovirus Insect Cells

FGF-8a Protein, Human, Recombinant

Cat.No: TMPY-00005

Species: Human

Expression System: E. coli

Tau Protein, Human, Recombinant (His)

Cat.No: TMPY-03425

Species: Human

Expression System: E. coli

CD74 Protein, Human, Recombinant (His)

Cat.No: TMPY-01199

Species: Human

Expression System: HEK293 Cells

CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05586

Species: Human

Expression System: HEK293 Cells

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