购物车
- 全部删除
您的购物车当前为空
Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441)
还可以产品编号 TMAY-01522
别名 PRKM3, p44-MAPK, P44MAPK, p44-ERK1, P44ERK1, HUMKER1A, HS44KDAP, ERT2, ERK-2, Erk2, ERK-1, ERK1
Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441) 是一种 Rabbit 抗体，靶向 Phospho-MEK1/2 (Ser217, 2210)。Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441) 可用于 WB。
Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441)
Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441)
还可以产品编号 TMAY-01522 别名 PRKM3, p44-MAPK, P44MAPK, p44-ERK1, P44ERK1, HUMKER1A, HS44KDAP, ERT2, ERK-2, Erk2, ERK-1, ERK1
Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441) 是一种 Rabbit 抗体，靶向 Phospho-MEK1/2 (Ser217, 2210)。Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441) 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 679 | 5日内发货 | |
| 100 μL | ¥ 1,984 | 5日内发货 |
大包装 & 定制
加入购物车
TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
联系我们获取更多批次信息
资源下载
产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441) is a Rabbit antibody targeting Phospho-MEK1/2 (Ser217, 2210). Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441) can be used in WB. |
| 别名 | PRKM3, p44-MAPK, P44MAPK, p44-ERK1, P44ERK1, HUMKER1A, HS44KDAP, ERT2, ERK-2, Erk2, ERK-1, ERK1 |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 8K441 |
| 交叉反应 | Human;
Species predicted to react based on 100% sequence homology: Mouse, Rat, Cynomolgus, Bovin |
| 验证活性 | 1. Western blot analysis of extracts from serum-starved Raji, untreated (line A); treated with TPA (200 nM, 30 min) (line B); treated with TPA and λ-phosphatase (line C) using Phospho-MEK1/2 (Ser217, 221) Antibody, Rabbit MAb at 1:1000 dilution. 2. Western blot analysis of extracts from serum-starved Raji, untreated (-) or treated with TPA (200 nM, 30 min) (+), using Phospho-MEK1/2 (Ser217, 221) Antibody, Rabbit Mab at 1:1000 dilution (upper) or Anti-MEK1 Antibody, Rabbit Polyclonal (middle) at 1:500 dilution or Beta-Tubulin Loading Control Antibody, Mouse Mab at 1:20000 dilution. 3. Western blot analysis of extracts from serum-starved Raji, untreated (line A); treated with TPA (200 nM, 30 min), without peptide (line B) or antigen-specific phosphopeptide (line C) or antigen-specific peptide (line D) using Phospho-MEK1/2 (Ser217, 221) Antibody, Rabbit MAb at 1:1000 dilution. (Validation Experiment) 4. Western blot analysis of extracts from serum-starved Raji, treated with TPA (200 nM, 30 min), using Phospho-MEK1/2 (Ser217, 221) Antibody, Rabbit Mab and other brands’ antibodies (Company C) at dilution of 1:2000, 1:10000. (Validation Experiment) |
| 应用 | WB |
| 推荐剂量 | WB: 1:2000-1:20000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Ser218 and Ser222 of the Human MEK1 (Uniprot: Q02750-1) and Ser222 and Ser226 of the Human MEK2 (Uniprot: P36507). Human MEK1 residue Ser218 and Ser222 historically has been referenced as Ser217 and Ser221. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| 研究背景 | MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MEK1 is widely expressed, with extremely low levels in the brain. It lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon a wide variety of extra- and intracellular signals. As an essential component of the MAP kinase signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation, and development. Binding extracellular ligands such as growth factors, cytokines, and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1 and MEK2. MEK1 has been shown to export PPARG from the nucleus. The MAPK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. MKK1 catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Defects in MEK1 can cause Cardiofaciocutaneous Syndrome.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic phosphopeptide corresponding to residues around Ser218 and Ser222 of the Human MEK1 (Uniprot: Q02750-1) and Ser222 and Ser226 of the Human MEK2 (Uniprot: P36507). Human MEK1 residue Ser218 |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
SCI 文献
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
评论列表
预览
Related Tags: buy Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441) | purchase Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441) | Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441) cost | order Anti-Phospho-MEK1/2 (Ser217, 2210) Antibody (8K441)
嗨！有任何问题？点我咨询
评论内容