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顶部生物活性储存和溶解信息计算器

Anti-MAPK3 Antibody (6G827)

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Anti-MAPK3 Antibody (6G827)
产品编号 TMAC-01367

Anti-MAPK3 Antibody (6G827) 是一种 Rabbit 抗体，靶向 MAPK3。Anti-MAPK3 Antibody (6G827) 可用于 WB,IP。

Anti-MAPK3 Antibody (6G827)

Anti-MAPK3 Antibody (6G827)

Rating icon 还可以
Anti-MAPK3 Antibody (6G827)
产品编号 TMAC-01367

Anti-MAPK3 Antibody (6G827) 是一种 Rabbit 抗体，靶向 MAPK3。Anti-MAPK3 Antibody (6G827) 可用于 WB,IP。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-MAPK3 Antibody (6G827) is a Rabbit antibody targeting MAPK3. Anti-MAPK3 Antibody (6G827) can be used in WB,IP.
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of Erk1 (pT202/pY204)+Erk2 (pT185/pY187) on A431 lysates using anti-Erk1 (pT202/pY204)+Erk2 (pT185/pY187) antibody at 1/1,000 dilution.
应用
WB
IP
推荐剂量
WB: 1:1000-2000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at Tyrosine 204 and 187 and Threonine 177 and 160 residues mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both the Threonine 202 and Tyrosine 204 residues of ERK1 and Threonine 185 and Tyrosine 187 residues of ERK2 is required for full enzymatic activation. The structural consequences of dual-phosphorylation in the ERK2 include active site closure, alignment of key catalytic residues that interact with ATP, and remodeling of the activation loop. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthesized phosphopeptide: human Erk1/2 around the phosphorylation site of Thr 202 and Tyr204/Thr 185 and Tyr187
抗原种属
human
Uniprot ID
P27361
化学信息
分子量Theoretical: 42/44 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器

关键词

PRKM3PRKM 3p44-MAPKp44MAPKp44-ERK1p44-ERK 1Mitogen-activated protein kinase 3Microtubule-associated protein 2 kinaseMAPK3MAPK 3MAP kinase3MAP kinase isoform p44 (p44-MAPK)MAP kinase 3Insulin-stimulated MAP2 kinaseExtracellular signal-regulated kinase 1 (ERK-1)ERT2ERT 2ERK-1ERK1ERK 1

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