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Search Results for " c-met "

Targets Recommended: c-Met/HGFR c-Met/HGFR

141

抑制剂 & 化合物

9

天然产物

1

TargetMol 试剂盒

25

重组蛋白

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Cat. No.	Product Name	Form	Specificity Of Inhibition
CL0089	c-Met/HGFR inhibitor kit c-Met/HGFR inhibitor kit

TargetMol 试剂盒

c-Met/HGFR inhibitor kit

Cat.No: CL0089

Cat. No.	Product Name	Target	Signaling Pathways
T10655	c-Met inhibitor 1 3-[(2-甲基-2H-吲唑-5-基)硫基]-6-(1-甲基-1H-吡唑-4-基)-1,2,4-三唑并[4,3-B]哒嗪	c-Met/HGFR	Tyrosine Kinase/Adaptors
	c-Met inhibitor 1 是一种 c-Met 受体信号通路抑制剂，可用于癌症的治疗，包括胶质母细胞瘤、胃癌和胰腺癌。
T9990	c-Met-IN-15	Antibacterial	Microbiology/Virology
	c-Met-IN-15 具有抗菌活性。
T5349	SCR-1481B1 麦他替尼胺丁三醇,c-Met inhibitor 2	VEGFR; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	SCR-1481B1 (c-Met inhibitor 2) 能够作用于依赖 Met 激活的癌症，对 VEGFR 具有抑制作用。
T10654	c-Met-IN-2	c-Met/HGFR	Tyrosine Kinase/Adaptors
	c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.
T10653	c-met-IN-1	c-Met/HGFR	Tyrosine Kinase/Adaptors
	c-met-IN-1 is a potent and selective c-Met inhibitor (IC50: 1.1 nM) with antitumor activity.
T7900	BAY-474	c-Met/HGFR	Tyrosine Kinase/Adaptors
	BAY-474 是酪氨酸蛋白激酶 c-MET 抑制剂，能够用于表观遗传学探针。
T67859	C-Met inhibitor D9	c-Met/HGFR	Tyrosine Kinase/Adaptors
	C-Met inhibitor D9 是一种c-Met 激酶抑制剂。
T6154	SU11274 Met Kinase Inhibitor,PKI-SU11274	Apoptosis; VEGFR; FGFR; c-Met/HGFR; CDK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	SU11274 (Met Kinase Inhibitor) 是一种选择性的 Met 抑制剂，IC50值为 10 nM。它对 PGDFRβ，EGFR 或 Tie2 没有抑制作用。
T2680	NVP-BVU972	c-Met/HGFR	Tyrosine Kinase/Adaptors
	NVP-BVU972 是 Met 选择性抑制剂 (IC50:14 nM) ，它对其它的激酶抑制性较低。
T2293	SGX-523	Raf; p38 MAPK; c-Met/HGFR; Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors
	SGX523 是选择性的和 ATP 竞争性的MET 抑制剂 (IC50:4 nM)。它对 MET 的选择性其它他蛋白激酶高 1000 倍。它具有抗肿瘤特性。
T6094	MK-2461 MK2461	c-Met/HGFR	Tyrosine Kinase/Adaptors
	MK-2461 是 ATP 竞争性的 c-Met 抑制剂, 平均 IC50 值为 2.5 nM。
T6095	JNJ-38877605	c-Met/HGFR	Tyrosine Kinase/Adaptors
	JNJ38877605 是 ATP 竞争性 c-Met 抑制剂 (IC50:4 nM)，对c-Met 的抑制性比对其它 200 种酪氨酸和丝氨酸-苏氨酸激酶的抑制性高 600 倍。
T8409	SYN1143 RON-IN-1,AMG-1	c-Met/HGFR	Tyrosine Kinase/Adaptors
	SYN1143 (AMG-1) 是人 RON 和 c-Met 的有效抑制剂。体外激酶测定表明 SYN1143 对人 RON 和 c-Met 的 IC50 分别为 9 和 4 nmol/L。
T9123	DS-1205	TAM Receptor	Tyrosine Kinase/Adaptors
	DS-1205b free base 是有效的AXL 激酶选择性抑制剂，IC50为 1.3 nM。它对MER，MET 和TRKA 也有抑制作用，IC50分别为 63、104 和 407 nM。它可以抑制细胞迁移和肿瘤生长。
T4332	c-Kit-IN-1 PDGFR inhibitor 1,DCC-2618	c-Met/HGFR; c-Kit	Tyrosine Kinase/Adaptors
	c-Kit-IN-1 (DCC-2618) 是c-Kit 和c-Met 抑制剂(IC50<200 nM)。
T6117	Tivantinib ARQ 197	Apoptosis; c-Met/HGFR	Apoptosis; Tyrosine Kinase/Adaptors
	Tivantinib (ARQ 197) 是一种高选择性c-Met 酪氨酸激酶抑制剂，Ki 为 355 nM。
T6378	AMG-458 AMG 458	c-Met/HGFR	Tyrosine Kinase/Adaptors
	AMG-458 是一种口服有活力的c-Met 选择性抑制剂，其对人和小鼠的Ki 分别为 1.2 nM 和 2.0 nM。
T11162	EGFR-IN-8	EGFR; c-Met/HGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-8 是 EGFR 和 c-Met 的双重抑制剂。 EGFR-IN-8可用于靶向 EGFR TKI 耐药的 NSCLC 的研究。
T3274	S49076	FGFR; c-Met/HGFR; TAM Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	S49076 是一种新型 MET、AXL/MER 和 FGFR1/2/3 高效抑制剂，IC50<20 nM。
T6260	AMG-208 AMG 208	P450; c-Met/HGFR	Metabolism; Tyrosine Kinase/Adaptors
	AMG-208 是一种选择性的、口服有活性的c-Met/RON 双抑制剂，对c-Met 的IC50为 9 nM。他也是CYP3A4抑制剂(IC50:32 μM)。它具有抗癌作用。
T6128	PHA-665752 PHA 665752,PHA665752	Apoptosis; VEGFR; FGFR; c-Met/HGFR; Bcr-Abl; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PHA-665752 是一种选择性的 ATP 竞争活性位点 c-Met 激酶抑制剂，Ki 为 4 nM，IC50为 9 nM。它对 c-Met 的选择性比一组不同的酪氨酸和丝氨酸苏氨酸激酶高 50 倍。它诱导细胞凋亡和细胞周期阻滞，具有细胞还原性抗肿瘤活性。
T2419	BMS-794833	VEGFR; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	BMS794833 是一种 VEGFR2 和 Met 的抑制剂，它们的 IC50值分别为 15 和 1.7 nM。
T37596	Terevalefim	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Terevalefim 是干细胞生长因子的一种类似物，对c-Met 受体有选择性激活作用。
T13194	CSF1R-IN-2	c-Fms; c-Met/HGFR; Src	Angiogenesis; Tyrosine Kinase/Adaptors
	CSF1R-IN-2 是一种口服具有活力的、有效的 SRC，MET 和 c-FMS 抑制剂，它们的 IC50 值分别为 0.12 nM，0.14 nM 和 0.76 nM。
TQ0041	Ningetinib Tosylate	VEGFR; c-Met/HGFR; TAM Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Ningetinib Tosylate 是口服具有活力的、小分子酪氨酸激酶抑制剂，能够抑制 c-Met (IC50:6.7 nM)，VEGFR2 (IC50:1.9 nM) 和 Axl (IC50<1.0 nM)。
T5467	SAR125844 SAR125884	Apoptosis; c-Met/HGFR	Apoptosis; Tyrosine Kinase/Adaptors
	SAR125844 是高度选择性可逆ATP 竞争性的MET 受体酪氨酸激酶抑制剂，其IC50值为4.2 nM。能抑制细胞中MET 的自磷酸化。
T5478	SRI 31215 TFA SRI 31215	c-Met/HGFR	Tyrosine Kinase/Adaptors
	SRI 31215 TFA 是 matriptase、hepsin、肝细胞生长因子激活剂(HGFA)的三重抑制剂，IC50值分别为 0.69 μM、0.65 μM、0.3 μM。它能够阻断 pro-HGF 的活化，模拟 HAI-1/2 的活性。
T6907	NPS-1034 NPS1034,NPS 1034	Apoptosis; c-Met/HGFR; TAM Receptor	Apoptosis; Tyrosine Kinase/Adaptors
	NPS-1034 是一种AXL 和MET 的双重抑制剂，其IC50值分别为 10.3 和 48 nM。
T15617	JNJ-38877618 OMO-1	c-Met/HGFR	Tyrosine Kinase/Adaptors
	JNJ-38877618 (OMO-1)是一种口服有活性的 Met 激酶选择性抑制剂，其对野生型和突变体的 IC50值分别为2和3 nM。
T2676	PF-04217903	c-Met/HGFR	Tyrosine Kinase/Adaptors
	PF04217903 是一种高效的、 ATP 竞争性的c-Met 激酶抑制剂(Ki=4.8 nM)，相对于 208 个激酶，PF04217903 显示出 1000 倍以上的选择性。它抗血管生成作用。
T2496	(Z)-Semaxinib SU5416	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	(Z)-Semaxinib (SU5416) 是一种有效的选择性 VEGFR(Flk-1/KDR) 抑制剂 (IC50: 1.23 μM)，对 VEGFR 的选择性是 PDGFRβ 的 20 倍，对 FGFR、InsR 和 EGFR 没有抑制作用。 Semaxanib 是一种具有潜在抗肿瘤活性的喹诺酮衍生物。
T3209	AMG-337 AMG337	c-Met/HGFR	Tyrosine Kinase/Adaptors
	AMG-337 是有效的、ATP 竞争性的、高度选择性的MET 激酶抑制剂，IC50 < 5 nM。
T9052	XL092 CL-092,JUN04542	VEGFR; c-Met/HGFR; TAM Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	XL092 (JUN04542) 是一种ATP 竞争性的、口服有效的多受体酪氨酸激酶 (RTKs) 抑制剂，在细胞分析中的MET (IC50:15 nM)、VEGFR2 (IC50:1.6 nM)、AXL (IC50:3.4 nM) 和 MER (IC50:7.2 nM)。它具有抗肿瘤作用，具有用于研究激酶依赖性疾病的潜力。
T5414	Glumetinib SCC244	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Glumetinib (SCC244) 是一种高选择性、ATP 竞争性的、口服具有活力的 c-Met 抑制剂。它对 c-Met 的选择性超过 312 种激酶，包括 c-Met 家族成员 RON 和高度同源的激酶 Axl、Mer、TyrO3。它具有抗肿瘤作用。
T6517	Golvatinib E-7050,戈伐替尼	VEGFR; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Golvatinib (E-7050) 是一种 c-Met (IC50:14 nM) 和 VEGFR2 (IC50:16 nM) 的双重抑制剂。
TQ0219	MK-8033	c-Met/HGFR	Tyrosine Kinase/Adaptors
	MK-8033 是一种新型ATP 竞争性c-Met/Ron 双重抑制剂，对野生型c-Met 的IC50=1 nM，对c-Met N1100Y 的IC50=2.0 nM。
T2699	BMS 777607 BMS777607,BMS-777607,BMS 817378	c-Met/HGFR; TAM Receptor	Tyrosine Kinase/Adaptors
	BMS 777607 (BMS 817378) 是 Met-related 抑制剂，能够抑制 c-Met (IC50:3.9 nM)，Axl (IC50:1.1 nM)，Ron (IC50:1.8 nM) 和 Tyro3 (IC50:4.3 nM) 的活性。
TQ0021	Ningetinib CT-053,CT053PTSA,宁格替尼	VEGFR; c-Met/HGFR; TAM Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Ningetinib (CT-053) 是口服具有活力的、小分子酪氨酸激酶抑制剂，能够抑制 c-Met (IC50:6.7 nM)，VEGFR2 (IC50:1.9 nM) 和 Axl (IC50<1.0 nM)。
T10585	Bozitinib CBT-101,PLB-1001	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Bozitinib (PLB-1001) 是一种可透过血脑屏障的、高效的、选择性的的、 ATP 竞争性的小分子 c-MET 激酶抑制剂，能够与酪氨酸激酶超家族的常规 ATP 结合口袋结合。
T4426	CEP-40783 CEP 40783,RXDX-106	c-Met/HGFR; TAM Receptor	Tyrosine Kinase/Adaptors
	CEP-40783 (RXDX-106) 是一种有口服活性的，高效的，选择性的 AXL (IC50:7 nM) 和 c-Met (IC50:12 nM) 抑制剂。
T3455	Merestinib LY2801653	Discoidin Domain Receptor (DDR); FLT; c-Met/HGFR; ROS; ROS Kinase	Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Merestinib (LY2801653) 是一种有效的口服生物可利用的具有抗肿瘤活性的c-Met 抑制剂。
T8825	Capmatinib 2HCl.H2O INCB28060 2HCl.H2O,INC-280 2HCl.H2O,NVP-INC280 2HCl.H2O	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) 是一种具有潜在抗肿瘤活性的原癌基因 c-Met (HGFR) 的口服生物可利用抑制剂。
TQ0210	Savolitinib AZD-6094,Volitinib,沃利替尼,赛沃替尼,HMPL-504	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Savolitinib (Volitinib) 是一种高效选择性、口服生物利用度c-Met 抑制剂，能够抑制 c-Met (IC50:5 nM)和 p-Met (IC50:3 nM)。它以 ATP 竞争的方式选择性结合并抑制 c-Met 的激活，破坏 c-Met 信号转导途径，具有抗肿瘤作用。
T1661	Crizotinib PF-02341066,克唑替尼	c-Met/HGFR; ROS; ALK; Autophagy; ROS Kinase	Angiogenesis; Autophagy; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Crizotinib (PF-02341066) 是 c-MET 和 ALK 受体的 ATP 竞争性小分子酪氨酸激酶抑制剂，IC50为 8和20 nM。在细胞的实验中，它抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化。它也是 ROS1抑制剂。它有肿瘤生长抑制作用。
T2516	Amuvatinib MP470,HPK 56	Apoptosis; FLT; c-Met/HGFR; c-RET; DNA/RNA Synthesis; PDGFR; c-Kit	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	Amuvatinib (MP470) 是一种多靶点酪氨酸激酶抑制剂，对突变 c-Kit，PDGFRα，Flt3，c-Met 和 c-Ret 具有活性。它还是一种 DNA 修复抑制剂，靶向蛋白 DNA 修复 RAD51，从而破坏 DNA 损伤修复，具有抗肿瘤活性。
T1963	Capmatinib NVP-INC280,INC-280,卡马替尼,INCB28060	Apoptosis; c-Met/HGFR	Apoptosis; Tyrosine Kinase/Adaptors
	Capmatinib (INCB28060) 是一种具有口服活性的，选择性的，ATP 竞争性的c-Met 激酶抑制剂，IC50值为0.13 nM。它有效抑制 c-Met 依赖性肿瘤细胞的增殖和迁移，可诱导细胞凋亡，有抗肿瘤活性。
T2054	Altiratinib DCC-2701	VEGFR; Tie-2; FLT; Trk receptor; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂，能够抑制 MET (IC50:2.7 nM)，TIE2 (IC50:8 nM)，VEGFR2 (IC50:9.2 nM)，FLT3 (IC50:9.3 nM)，Trk1 (IC50:0.85 nM)，Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。
T8416	Capmatinib xHCl INCB28060,Capmatinib hydrochloride(free base),INC280	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Capmatinib xHCl (INCB28060) 是一种有效的、口服活性的、选择性的和 ATP 竞争性 c-Met 激酶抑制剂，有效地阻断体外激酶活性 (IC50 = 0.13 nM) 以及在细胞中的组成型或 HGF 刺激活性(IC50 值范围从 0.3 到1.1纳米)。
TP2382	Gastrin hexapeptide Tyr-gly-trp-met-asp-phe-NH2,Gastrin C-terminal hexapeptide
	Gastrin hexapeptide is a hexapeptide from porcine antral mucosa.
T6351	MGCD-265 analog MGCD-265,Glesatinib	Apoptosis; VEGFR; c-Met/HGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	MGCD-265 analog (Glesatinib) 是一种口服生物可利用的多靶点酪氨酸激酶抑制剂，具有抗肿瘤活性，对 c-Met 和 VEGFR2 的 IC50 分别为 29 nM 和 10 nM。

化合物

c-Met inhibitor 1

Cat.No: T10655

Synonym: 3-[(2-甲基-2H-吲唑-5-基)硫基]-6-(1-甲基-1H-吡唑-4-基)-1,2,4-三唑并[4,3-B]哒嗪

Target: c-Met/HGFR

Cat.No: T9990

Target: Antibacterial

Cat.No: T5349

Synonym: 麦他替尼胺丁三醇,c-Met inhibitor 2

Target: VEGFR, c-Met/HGFR

Cat.No: T10654

Target: c-Met/HGFR

Cat.No: T10653

Target: c-Met/HGFR

Cat.No: T7900

Target: c-Met/HGFR

C-Met inhibitor D9

Cat.No: T67859

Target: c-Met/HGFR

Cat.No: T6154

Synonym: Met Kinase Inhibitor,PKI-SU11274

Target: Apoptosis, VEGFR, FGFR, c-Met/HGFR, CDK, Autophagy

Cat.No: T2680

Target: c-Met/HGFR

Cat.No: T2293

Target: Raf, p38 MAPK, c-Met/HGFR, Bcr-Abl

Cat.No: T6094

Synonym: MK2461

Target: c-Met/HGFR

Cat.No: T6095

Target: c-Met/HGFR

Cat.No: T8409

Synonym: RON-IN-1,AMG-1

Target: c-Met/HGFR

Cat.No: T9123

Target: TAM Receptor

Cat.No: T4332

Synonym: PDGFR inhibitor 1,DCC-2618

Target: c-Met/HGFR, c-Kit

Cat.No: T6117

Synonym: ARQ 197

Target: Apoptosis, c-Met/HGFR

Cat.No: T6378

Synonym: AMG 458

Target: c-Met/HGFR

Cat.No: T11162

Target: EGFR, c-Met/HGFR

Cat.No: T3274

Target: FGFR, c-Met/HGFR, TAM Receptor

Cat.No: T6260

Synonym: AMG 208

Target: P450, c-Met/HGFR

Cat.No: T6128

Synonym: PHA 665752,PHA665752

Target: Apoptosis, VEGFR, FGFR, c-Met/HGFR, Bcr-Abl, Autophagy

Cat.No: T2419

Target: VEGFR, c-Met/HGFR

Cat.No: T37596

Target: c-Met/HGFR

Cat.No: T13194

Target: c-Fms, c-Met/HGFR, Src

Ningetinib Tosylate

Cat.No: TQ0041

Target: VEGFR, c-Met/HGFR, TAM Receptor

Cat.No: T5467

Synonym: SAR125884

Target: Apoptosis, c-Met/HGFR

Cat.No: T5478

Synonym: SRI 31215

Target: c-Met/HGFR

Cat.No: T6907

Synonym: NPS1034,NPS 1034

Target: Apoptosis, c-Met/HGFR, TAM Receptor

Cat.No: T15617

Synonym: OMO-1

Target: c-Met/HGFR

Cat.No: T2676

Target: c-Met/HGFR

Cat.No: T2496

Synonym: SU5416

Target: VEGFR

Cat.No: T3209

Synonym: AMG337

Target: c-Met/HGFR

Cat.No: T9052

Synonym: CL-092,JUN04542

Target: VEGFR, c-Met/HGFR, TAM Receptor

Cat.No: T5414

Synonym: SCC244

Target: c-Met/HGFR

Cat.No: T6517

Synonym: E-7050,戈伐替尼

Target: VEGFR, c-Met/HGFR

Cat.No: TQ0219

Target: c-Met/HGFR

Cat.No: T2699

Synonym: BMS777607,BMS-777607,BMS 817378

Target: c-Met/HGFR, TAM Receptor

Cat.No: TQ0021

Synonym: CT-053,CT053PTSA,宁格替尼

Target: VEGFR, c-Met/HGFR, TAM Receptor

Cat.No: T10585

Synonym: CBT-101,PLB-1001

Target: c-Met/HGFR

Cat.No: T4426

Synonym: CEP 40783,RXDX-106

Target: c-Met/HGFR, TAM Receptor

Cat.No: T3455

Synonym: LY2801653

Target: Discoidin Domain Receptor (DDR), FLT, c-Met/HGFR, ROS, ROS Kinase

Capmatinib 2HCl.H2O

Cat.No: T8825

Synonym: INCB28060 2HCl.H2O,INC-280 2HCl.H2O,NVP-INC280 2HCl.H2O

Target: c-Met/HGFR

Cat.No: TQ0210

Synonym: AZD-6094,Volitinib,沃利替尼,赛沃替尼,HMPL-504

Target: c-Met/HGFR

Cat.No: T1661

Synonym: PF-02341066,克唑替尼

Target: c-Met/HGFR, ROS, ALK, Autophagy, ROS Kinase

Cat.No: T2516

Synonym: MP470,HPK 56

Target: Apoptosis, FLT, c-Met/HGFR, c-RET, DNA/RNA Synthesis, PDGFR, c-Kit

Cat.No: T1963

Synonym: NVP-INC280,INC-280,卡马替尼,INCB28060

Target: Apoptosis, c-Met/HGFR

Cat.No: T2054

Synonym: DCC-2701

Target: VEGFR, Tie-2, FLT, Trk receptor, c-Met/HGFR

Capmatinib xHCl

Cat.No: T8416

Synonym: INCB28060,Capmatinib hydrochloride(free base),INC280

Target: c-Met/HGFR

Gastrin hexapeptide

Cat.No: TP2382

Synonym: Tyr-gly-trp-met-asp-phe-NH2,Gastrin C-terminal hexapeptide

MGCD-265 analog

Cat.No: T6351

Synonym: MGCD-265,Glesatinib

Target: Apoptosis, VEGFR, c-Met/HGFR

Cat. No.	Product Name	Target	Signaling Pathways
T13108	Pamufetinib H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115	VEGFR; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Pamufetinib (TAS-115) 是VEGFR 和c-Met/HGFR 抑制剂，能够抑制 rVEGFR2 (IC50:30 nM)和 rMET (IC50:32 nM)的活性。
T5656	(±)-Norcantharidin Endothall anhydride,去甲斑蝥素,Norcantharidin	EGFR; c-Met/HGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	(±)-Norcantharidin (Endothall anhydride) 是一种人类结肠癌中 c-Met 和 EGFR 的双重抑制剂，可研究抗癌，具有抗血管生成活性。
T2894	Norcantharidin Norcantharadine,去甲斑蝥素,Endothall anhydride	EGFR; c-Met/HGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Norcantharidin (Norcantharadine) 是一种合成的抗癌化合物，是人类结肠癌中 c-Met 和 EGFR 的双重抑制剂。
T3S0335	Soyasaponin Bb Soyasaponin I,大豆皂苷Bb	NF-κB; Caspase	Apoptosis; NF-κB; Proteases/Proteasome
	Soyasaponin Bb (Soyasaponin I) 是一种分离自菜豆科中的大豆皂苷，可用作醛糖还原酶差异抑制剂。
T5S1331	Herbacetin	c-Met/HGFR; Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Herbacetin 是一种亚麻籽中的天然类黄酮，具有多种药理活性，如抗氧化、抗炎、抗癌作用。它是鸟氨酸脱羧酶Ornithine decarboxylase (ODC)变构抑制剂，能够直接与 ODC 上的 Asp44，Asp243 和 Glu384 结合。其中鸟氨酸脱羧酶是多胺生物合成中的限速酶。
TJS0339	Coumarin-3-carboxylic acid 香豆素-3-羧酸,3-Carboxycoumarin	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Coumarin-3-carboxylic acid (3-Carboxycoumarin) 是一种合成香豆素的重要起始化合物。其中香豆素是具有多种生物活性的天然产物。它的镧系复合物对 K-562 细胞具有抗增殖活性。
T16035	Meleagrin	Others	Others
	Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities.
TN1549	Damnacanthal 丹宁卡	IL Receptor; Akt; Syk	Angiogenesis; Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis.
TN4023	Eucalyptin	Antifection	Microbiology/Virology
	Eucalyptin has antioxidant and antimicrobial properties, it exhibits potent antimicrobial activities against seven micro-organisms with minimum inhibitory concentrations (MIC) ranging from 1.0 to 31 mg/L. Eucalyptin A exhibits potent inhibition on HGF/c-M

天然产物

Cat.No: T13108

Synonym: H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115

Target: VEGFR, c-Met/HGFR

(±)-Norcantharidin

Cat.No: T5656

Synonym: Endothall anhydride,去甲斑蝥素,Norcantharidin

Target: EGFR, c-Met/HGFR

Cat.No: T2894

Synonym: Norcantharadine,去甲斑蝥素,Endothall anhydride

Target: EGFR, c-Met/HGFR

Cat.No: T3S0335

Synonym: Soyasaponin I,大豆皂苷Bb

Target: NF-κB, Caspase

Cat.No: T5S1331

Target: c-Met/HGFR, Akt

Coumarin-3-carboxylic acid

Cat.No: TJS0339

Synonym: 香豆素-3-羧酸,3-Carboxycoumarin

Target: VEGFR

Cat.No: T16035

Target: Others

Cat.No: TN1549

Synonym: 丹宁卡

Target: IL Receptor, Akt, Syk

Cat.No: TN4023

Target: Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01896	HGFR/c-Met Protein, Mouse, Recombinant (His) MET proto-oncogene, receptor tyro...	Mouse	HEK293 Cells
	HGFR/c-Met Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102 kDa and the accession number is EDL13881.1.
TMPY-01296	HGFR/c-Met Protein, Human, Recombinant (His) AUTS9,MET proto-oncogene, recepto...	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is A0A024R759.
TMPK-00499	HGFR/c-Met Protein, Cynomolgus, Recombinant (His) MET,oncogene MET,cME...	Cynomolgus	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ...
TMPY-01895	HGFR/c-Met Protein, Mouse, Recombinant (hFc) c-Met,AI838057,MET proto-onc<...	Mouse	HEK293 Cells
	HGFR/c-Met Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128 kDa and the accession number is A4FUV6.
TMPK-00457	HGFR/c-Met Protein, Human, Recombinant (His & Avi) cMET,Met (c-Met...	Human	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ...
TMPY-05441	HGFR/c-Met Protein, Human, Recombinant (hFc) HGFR,DFNB97,RCCP2,AUTS9,c-Met...	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128.4 kDa and the accession number is A0A024R759.
TMPY-00718	HGFR/c-Met Protein, Human, Recombinant (His & hFc) DFNB97,RCCP2,AUTS9,MET proto-on	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 129.5 kDa and the accession number is A0A024R759.
TMPY-05607	HGFR/c-Met Protein, Human, Recombinant (His & Avi), Biotinylated MET proto-oncogene, receptor tyro...	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 104.9 kDa and the accession number is A0A024R759.
TMPY-04379	HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST) MET proto-oncogene, receptor tyro...	Human	Baculovirus Insect Cells
	HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.8 kDa and the accession number is P08581-1.
TMPJ-00415	HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated SF receptor,HGF receptor,Scatter ...	Human	HEK293 Cells
	Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domai...
TMPY-00548	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) MET proto-oncogene, receptor tyro...	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is G7MM61.
TMPY-03581	HGFR/c-Met Protein, Rat, Recombinant (hFc) MET proto-oncogene, receptor tyro...	Rat	HEK293 Cells
	HGFR/c-Met Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128.1 kDa and the accession number is Q2IBC7.
TMPY-02068	HGFR/c-Met Protein, Canine, Recombinant (His) MET proto-oncogene, receptor tyro...	Canine	HEK293 Cells
	HGFR/c-Met Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is Q75ZY9.
TMPY-00634	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant MET proto-oncogene, receptor tyro...	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 102.3 kDa and the accession number is G7MM61.
TMPY-06657	HGFR/c-Met Protein, Rat, Recombinant (His) MET proto-oncogene, receptor tyro...	Rat	HEK293 Cells
	HGFR/c-Met Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102.53 kDa and the accession number is XP_006236191.1.
TMPY-00546	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (hFc) MET proto-oncogene, receptor tyro...	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128.3 kDa and the accession number is G7MM61.
TMPY-06278	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated MET proto-oncogene, receptor tyro...	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is NP_001162100.2.
TMPJ-00375	HGF Protein, Human, Recombinant (His) Scatter factor,Hepatocyte growth ...	Human	HEK293 Cells
	HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET. HGF regulates epithelia...
TMPK-00369	HGF Protein, Human, Recombinant (hFc) HGF,F-TCF,HGFB,SF,F-TCFB,肝细胞生长因子,DFNB39,He...	Human	HEK293 Cells
	Hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity. HGF has a role in the metabolic flux of glucose in different insulin sensitive cell types; plays a key role in β-cell homeostasis; and is capable of modulating the inflammatory response.HGF plays a central role in these metabolic disorders,HGF levels could be employed as a biomarker for disease status/progression, and HGF/c-Met signaling pa...
TMPY-02028	RON/CD136 Protein, Human, Recombinant (His) CD136,macrophage stimulating 1 rec	Human	HEK293 Cells
	The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in...
TMPJ-00891	Kallikrein 2/KLK2 Protein, Human, Recombinant (His) hGK-1,Kallikrein-2,Tissue Kallikrein-2,KLK2,Glandular Kallik...	Human	HEK293 Cells
	Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-\|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-\|-Xaa or Leu-\|-Xaa. KLK2 ...
TMPJ-01184	CPA4 Protein, Mouse, Recombinant (His) CPA4,Carboxypeptidase A4	Mouse	HEK293 Cells
	Carboxypeptidase A4 (CPA4) is a member of the peptidase M14 family. CPA4 is metalloprotease that could be involved in the histone hyperacetylation pathway. CPA4 binds one zinc ion per subunit and could catalyze to release of a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val.They have distinct expression patterns and different specificities for example, preferentially cleaving aromatic (carboxypeptidase As) or basic (carboxypeptidase Bs) residues. Several, such as...
TMPK-01450	HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi), Biotinylated KRAS1,MHC,K-RAS4B,KRAS,CFC2,K-RAS...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01456	HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein, Human, MHC (His & Avi) KRAS2,NS,MHC,C-K-RAS,KRAS1,K-RAS2A,K-RAS2B...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01451	HLA-C 03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi) NS3,K-RAS4A,K-Ras 2,NS,KRAS1,RASK2,MHC,KI-RAS,KRAS,...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

重组蛋白

HGFR/c-Met Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01896

Species: Mouse

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His)

Cat.No: TMPY-01296

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00499

Species: Cynomolgus

Expression System: HEK293 Cells

HGFR/c-Met Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01895

Species: Mouse

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00457

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05441

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00718

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05607

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST)

Cat.No: TMPY-04379

Species: Human

Expression System: Baculovirus Insect Cells

HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated

Cat.No: TMPJ-00415

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)

Cat.No: TMPY-00548

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

HGFR/c-Met Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03581

Species: Rat

Expression System: HEK293 Cells

HGFR/c-Met Protein, Canine, Recombinant (His)

Cat.No: TMPY-02068

Species: Canine

Expression System: HEK293 Cells

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant

Cat.No: TMPY-00634

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

HGFR/c-Met Protein, Rat, Recombinant (His)

Cat.No: TMPY-06657

Species: Rat

Expression System: HEK293 Cells

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (hFc)

Cat.No: TMPY-00546

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated

Cat.No: TMPY-06278

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

HGF Protein, Human, Recombinant (His)

Cat.No: TMPJ-00375

Species: Human

Expression System: HEK293 Cells

HGF Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00369

Species: Human

Expression System: HEK293 Cells

RON/CD136 Protein, Human, Recombinant (His)

Cat.No: TMPY-02028

Species: Human

Expression System: HEK293 Cells

Kallikrein 2/KLK2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00891

Species: Human

Expression System: HEK293 Cells

CPA4 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01184

Species: Mouse

Expression System: HEK293 Cells

HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01450

Species: Human

Expression System: HEK293 Cells

HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01456

Species: Human

Expression System: HEK293 Cells

HLA-C 03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01451

Species: Human

Expression System: HEK293 Cells

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