Name: Anti-HGF/SF Antibody (TAK-701)
Brand: TargetMol
SKU: T9901A-1423
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-HGF/SF Antibody (TAK-701) represents a highly specialized humanized monoclonal antibody specifically engineered to target the human hepatocyte growth factor which acts as a pivotal ligand for the c-Met receptor tyrosine kinase across various malignancies, effectively facilitating the measurable neutralization of HGF-induced signaling to evaluate its role in cancer cell survival and metastasis during strictly monitored laboratory observation periods.
体外活性	在利用 NSCLC 细胞系和分泌 HGF 的成纤维细胞进行的共培养实验中，Anti-HGF/SF Antibody (TAK-701) 阻断了 HGF 诱导的 c-MET 磷酸化并逆转了吉非替尼耐药 [1]。
体内活性	在携带肿瘤源性 HGF 的 NSCLC 小鼠模型中，通过全身给药方式给予 Anti-HGF/SF Antibody (TAK-701) 抑制了肿瘤生长并增强了 EGFR 抑制剂的效力 [1]。
别名	抗HGF/SF抗体 (TAK-701), TAK-701
克隆号	TAK-701
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P14210
靶点	HGF/SF

储存&溶解度

存储

Anti-HGF/SF Antibody (TAK-701)