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Search Results for " her2 "

Targets Recommended: EGFR HER

158

抑制剂 & 化合物

3

天然产物

2

化合物库

1

TargetMol 试剂盒

33

重组蛋白

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Cat. No.	Product Name
L2191	抗乳腺癌化合物库		1939 compounds
	1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；
L2192	抗胰腺癌化合物库		2238 compounds
	2238 种与胰腺癌相关的化合物，可以用于高通量和高内涵筛选；

化合物库

抗乳腺癌化合物库

Cat.No: L2191

Compounds: 1939

抗胰腺癌化合物库

Cat.No: L2192

Compounds: 2238

Cat. No.	Product Name	Form	Specificity Of Inhibition
CL0098	HER2 inhibitor kit HER2 inhibitor kit

TargetMol 试剂盒

HER2 inhibitor kit

Cat.No: CL0098

Cat. No.	Product Name	Target	Signaling Pathways
T2518	ARRY-380 (analog ) HER2-Inhibitor-1,ARRY380,ARRY-380 analog	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	ARRY-380 analog (HER2-Inhibitor-1) 是EGFR (ErbB1)的抑制剂。
TP1583	HER2/neu (654-662) GP2
	Affibody (affibody) ligands that are specific for the extracellular domain of human epidermal growth factor receptor 2 (HER2/neu) have been selected by phage display technology from a combinatorial protein library based on the 58 amino acid residue staphy
TP1583L	HER2/neu (654-662) GP2 acetate	HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	HER2/neu (654-662) GP2 acetate 来源于人表皮生长因子受体 2 (HER2-Neu, 654-662)。 HER2/neu (654-662) GP2 acetate 诱导对各种上皮癌有反应的 HLA-A2 限制性细胞毒性 T 淋巴细胞。
T63881	HER2-IN-8
	HER2-IN-8 是 HER-2 抑制剂，能够用于癌症和炎症相关疾病的研究。
T64254	EGFR/HER2-IN-5
	EGFR/HER2-IN-5 是一种不可逆的、口服具有活力的双重抑制剂，能够抑制 EGFR 的活性 (IC50: 0.6 nM)。EGFR/HER2-IN-4 对 L858R 和 T790M 突变显示出有效的 EGFR 激酶抑制活性。EGFR/HER2-IN-4 在体内表现出明显的抗肿瘤作用，能够用于研究肺癌。
T62487	HER2-IN-12
	HER2-IN-12 是一种 HER2 抑制剂，其 IC50 值为 121 nM，能够用于研究癌症（如乳腺癌）。
T75165	HER2-IN-14
	HER2-IN-14（Compound 34），作为一种HER2抑制剂，展现出18 nM的IC50值。此外，该化合物对wt-EGFR也有抑制作用，IC50值为6.3 μM。
T62271	HER2-IN-9
	HER2-IN-9 是一种口服具有活力的 HER2 抑制剂 (IC50: 0.03 μM)。HER2-IN-9 对 HER-2 阳性的乳腺癌细胞增殖和迁移有抑制作用，能够用于研究乳腺癌。
T75164	HER2-IN-13
	HER2-IN-13（Compound 33），作为一种HER2抑制剂，展现出8 nM的IC50值。此外，对wt-EGFR也具有一定的抑制效果，其IC50值为0.40 μM。
T63432	HER2-IN-5
	HER2-IN-5 是一种口服具有活力的 HER-2 的有效抑制剂
T60896	HER2-IN-11
	HER2-IN-11 是能够诱导细胞凋亡的补骨脂素衍生物。HER2-IN-11 显示出光激活细胞毒性，并且具有抗乳腺癌活性。
T61596	EGFR/HER2/DHFR-IN-1
	EGFR/HER2/DHFR-IN-1 is a highly selective and potent anticancer compound specifically targeting MCF-7 breast cancer cells. It acts as a multi-inhibitor, targeting the EGFR/HER2 kinase and DHFR enzymes, with IC50 values of 0.153 μM, 0.108 μM, and 0.291 μM, respectively. Its mechanism of action involves cell cycle arrest at the G1/S phase and induction of apoptosis in cells [1].
T63441	HER2-IN-6
	HER2-IN-6 是 HER2 的有效抑制剂。HER2-IN-6 具有潜力进行野生和/或突变 EGFR 和/或 HER2 激酶介导的肿瘤的研究。
T64003	HER2-IN-7
	HER2-IN-7 是 HER2 的有效抑制剂。其中 ErbB 家族信号的失调调节增殖、侵袭、转移、血管生成和肿瘤细胞存活。HER2-IN-7 对 ErbBs (尤其是HER2) 相关疾病表现出研究潜力，包括癌症。
T60572	HER2-IN-10
	HER2-IN-10 是一种可以诱导细胞凋亡的补骨脂素衍生物。HER2-IN-10 显示出抗乳腺癌活性和光激活细胞毒性
T63401	EGFR/HER2/TS-IN-1
	EGFR/HER2/TS-IN-1 是 EGFR、HER2和TS (Thymidylate synthase)抑制剂，他们的IC50值分别为 0.203、0.088 和 0.168 μM，具有诱导 MCF7 细胞凋亡（apoptosis）的作用。
T82492	EGFR/HER2/DHFR-IN-3	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/HER2/DHFR-IN-3（compound 4c）是一种针对EGFR和HER2的高效双重抑制剂，其IC50分别为0.138 μM和0.092 μM。该化合物同时对DHFR具有抑制作用，IC50为0.193 M。在生物活性方面，EGFR/HER2/DHFR-IN-3能够导致MCF7乳腺癌细胞周期在S期发生阻滞，并进而诱导细胞凋亡。
T62746	EGFR/HER2/CDK9-IN-1
	EGFR/HER2/CDK9-IN-1 (Compound 4) 是一种有效的 EGFR/HER2/CDK9 抑制剂，他们的 IC50 值分别为 90.17、131.39 和 67.04 nM。EGFR/HER2/CDK9-IN-1 表现出明显的抗肿瘤作用。
T63357	EGFR/HER2/CDK9-IN-2
	EGFR/HER2/CDK9-IN-2 是 EGFR/HER2/CDK9 的有效抑制剂，他们的 IC50s 值分别为 145.35、129.07 和 117.13 nM，表现出明显的抗肿瘤作用。
T63161	EGFR/HER2/CDK9-IN-3
	EGFR/HER2/CDK9-IN-3 (Compound 10) 是一种有效的 EGFR (IC50: 191.08 nM)、HER2 (IC50: 132.65 nM) 和 CDK9 (IC50: 113.98 nM) 抑制剂。EGFR/HER2/CDK9-IN-3 表现出明显的抗肿瘤作用。
T62776	EGFR/HER2-IN-2
	EGFR/HER2-IN-2 (Compound ZINC35560729) 是一种 EGFR 和 HER2 双重抑制剂，作用于 EGFR (IC50: 5.02 μM) 和 HER2 (IC50: 0.83 μM)。
T62777	EGFR/HER2-IN-3
	EGFR/HER2-IN-3 (Compound ZINC21942954) 是一种双重的 EGFR 和 HER2 抑制剂。
T72854	EGFR/HER2-IN-9
	EGFR/HER2-IN-9 是一种 EGFR 和 HER2抑制剂，对 EGFR、EGFR T790M 和 HER2 的 IC50分别为 3.2、8.3 和 14 nM。
T64253	EGFR/HER2-IN-4
	EGFR/HER2-IN-4 是一种不可逆的、口服具有活力的双重抑制剂，能够抑制 EGFR 的活性 (IC50: 0.6 nM)。EGFR/HER2-IN-4 对 L858R 和 T790M 突变显示出有效的 EGFR 激酶抑制活性。EGFR/HER2-IN-4 在体内表现出明显的抗肿瘤作用，能够用于研究肺癌。
T61272	EGFR/HER2-IN-7
	EGFR/HER2-IN-7 is a highly selective and potent anticancer compound specifically designed to target MCF-7 breast cancer cells. It functions as a dual inhibitor, targeting both EGFR/HER2 kinases and DHFR (dihydrofolate reductase). Its inhibitory activities are measured with IC50 values of 0.18 μM for EGFR, 0.146 μM for HER2, and 0.907 μM for DHFR [1].
T63532	EGFR/HER2/TS-IN-2
	EGFR/HER2/TS-IN-2 是 EGFR (IC50: 0.173 μM)、HER2 (IC50: 0.125 μM) 和 TS (IC50: 1.12 μM) 的有效抑制剂。EGFR/HER2/TS-IN-2 对 MDA-MB-231 癌细胞表现出细胞毒性作用 (IC50: 1.69 μM)。
T82493	EGFR/HER2/DHFR-IN-2	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/HER2/DHFR-IN-2 (Compound 4b) 是针对EGFR、HER2和DHFR的三重抑制剂，IC50分别为0.248、0.156、0.138 μM。该化合物对包括Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7在内的多种癌细胞系展现出显著的抗癌活性(IC50分别为9.14、7.33、14.18、24.87、20.07、6.16 μM)，并能有效减缓乳腺癌肿瘤的生长。
T11917	Lys-SMCC-DM1 Lys-Nε-MCC-DM1	Microtubule Associated	Cytoskeletal Signaling
	DM1 是一种微管蛋白抑制剂。 Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) 是 DM1 的活性代谢物。
T9912	Trastuzumab	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Trastuzumab 是人源化单克隆抗体，以高亲和力与HER2选择性结合，可用于 HER2 阳性转移性乳腺癌和 HER2 阳性胃癌的研究。
T60938	EGFR/HER2-IN-8
	EGFR/HER2-IN-8 (compound 34) 是EGFR/HER2和DHFR 的抑制剂，其对 EGFR，HER2 和 DHFR 的IC50值分别为 0.45，0.244 和 5.669 μM。EGFR/HER2-IN-8 可用于癌症研究，它对多种癌细胞系表现出抗癌活性，具有高安全性和选择性指数。
T61732	EGFR/HER2-IN-6
	EGFR/HER2-IN-6 (compound 43) is a dual EGFR/HER2 and DHFR inhibitor with potent activity against EGFR kinase, HER2 kinase, and DHFR, characterized by IC50 values of 0.122 μM, 0.078 μM, and 0.585 μM, respectively. This compound displays notable anticancer properties in various cancer cell lines, while demonstrating a favorable safety profile and selectivity indices. Consequently, EGFR/HER2-IN-6 holds promise as a valuable tool in cancer research [1].
T6039	TAK-285 TAK285,TAK 285	EGFR; MEK; HER; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Tyrosine Kinase/Adaptors
	TAK-285 是一种新型 HER2 和 EGFR(HER1) 双重抑制剂，IC50 分别为 17 和 23 nM。它可穿过血脑屏障，有抗肿瘤活性，对 HER1/2 的选择性是 HER4 的 10 倍以上。
T11249L	Dxd Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ	Topoisomerase	DNA Damage/DNA Repair
	Dxd (OQM5SD32BQ) 是一种有效的DNA 拓扑异构酶 I 抑制剂，IC50值为 0.31 μM，用作HER2靶向ADC 的偶联药物。
T1785	Palbociclib PD 0332991,帕博西尼,帕布昔利布	CDK	Cell Cycle/Checkpoint
	Palbociclib (PD 0332991) 是一种 CDK 抑制剂，抑制 CDK4 和 CDK6 (IC50=11/16 nM)，具有口服活性。Palbociclib 具有抗肿瘤活性，有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T21312	Afatinib 阿法替尼,Afatinib free base,BIBW 2992	EGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Afatinib (BIBW 2992) 是一种不可逆的 EGFR 家族抑制剂，抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。
T6239	Palbociclib monohydrochloride PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl	CDK	Cell Cycle/Checkpoint
	Palbociclib monohydrochloride (PD 0332991 hydrochloride) 是一种口服的细胞周期蛋白依赖性激酶 (CDK) 抑制剂，具有潜在的抗肿瘤活性。它抑制 CDK4和 CDK6，IC50分别为11 nM，16 nM。它有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T6240	Palbociclib Isethionate Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐	CDK	Cell Cycle/Checkpoint
	Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。
T1773	Afatinib Dimaleate 马来酸阿法替尼,双马来酸盐阿法替尼,BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate	EGFR; HER; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Afatinib Dimaleate (BIBW 2992MA2) 是一种可口服的苯胺基-喹唑啉衍生物和受体酪氨酸激酶表皮生长因子受体家族的抑制剂，具有抗肿瘤活性。它抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。
T9304	(S)-Sunvozertinib N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	(S)-Sunvozertinib (DZD9008) 是 Sunvozertinib 的 S-对映体，能够抑制EGFR 外显子 20 NPH 和 ASV 插入、EGFR L858R/T790M 突变及 Her2 外显子 20 YVMA 插入，也能够抑制BTK。
T63643	BI-4142	HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BI-4142 是一种具有口服活性、高效和选择性的 HER2 抑制剂，抑制癌细胞增殖，抑制her2依赖性细胞系并抑制下游信号传导。
T34760	SYR127063 SYR-127063,BDBM 92454,SYR 127063,BDBM-92454,BDBM92454	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	SYR127063 (BDBM-92454) 是一种有效的选择性 HER2 抑制剂，以反应构象与 HER2 结合。
T6124	Mubritinib 木利替尼,TAK-165	EGFR; FGFR; JAK; PDGFR	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Mubritinib (TAK-165) 是选择性的EGFR2/HER2抑制剂，IC50值为6 nM。
T7819	TAS0728	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	TAS0728 是一种 HER2 抑制剂，与HER2的 C805 位点共价结合，IC50值为 13 nM。它抑制 HER2、HER3 及其下游效应蛋白的磷酸化，具有抗肿瘤活性。
T9909	Pertuzumab 帕妥珠单抗,帕妥株单抗	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Pertuzumab 是人源化单克隆抗体，是HER2二聚化抑制剂，可用于转移性 HER2 阳性乳腺癌的研究。
T12594	Pyrotinib dimaleate SHR-1258 dimaleate	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Pyrotinib dimaleate (SHR-1258 dimaleate) 是选择性的 EGFR/HER2双重抑制剂，IC50值分别为 13 和 38 nM。
T5398	BMS 599626 2HCl (873837-23-1(HCl)) AC480 dihydrochloride	HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) 是 HER1 和 HER2 的选择性抑制剂（IC50：20 nM 和 30 nM），对 HER4 的效力降低约 8 倍，对 Lck、VEGFR2、c-Kit、MET 等的效力降低 100 倍以上。
T9072	Tuxobertinib BDTX-189	EGFR; HER; BTK; RIP kinase	Angiogenesis; Apoptosis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors
	Tuxobertinib (BDTX-189) 是一种高效可口服的选择性 EGFR 和 HER2变构突变抑制剂，具有抗癌活性。它对 EGFR、HER2、BLK 和 RIPK2 的 KD 值分别为 0.2、0.76、13 和 1.2 nM。
T5390	BMS-599626 Hydrochloride AC480 Hydrochloride	HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BMS-599626 Hydrochloride (AC480 Hydrochloride) 是一种口服生物有效的HER1、HER2和HER4酪氨酸激酶抑制剂(IC50分别为22、32和190 nM)，具有潜在的抗肿瘤活性。BMS-599626 Hydrochloride 抑制人表皮生长因子受体HER1, HER2和HER4，从而抑制过表达这些受体的肿瘤细胞的增殖。
T69534	Zongertinib BI 764532,BI 1810631	Tyrosine Kinases; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Zongertinib 是一种人类HER2选择性酪氨酸激酶抑制剂，是一种高度选择性共价结合在HER2酪氨酸激酶域 (TKD)的新型TK。Zongertinib 具有抗肿瘤活性，对 pHER2 和 EGF 具有抑制作用。
T11213	Epertinib hydrochloride S-22611 hydrochloride	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Epertinib hydrochloride (S-22611 hydrochloride) 是口服可逆的选择性EGFR、HER2和HER4抑制剂，IC50值分别为 1.48、7.15 和 2.49 nM，具有抗肿瘤活性。

化合物

ARRY-380 (analog )

Cat.No: T2518

Synonym: HER2-Inhibitor-1,ARRY380,ARRY-380 analog

Target: EGFR, HER

HER2/neu (654-662) GP2

Cat.No: TP1583

HER2/neu (654-662) GP2 acetate

Cat.No: TP1583L

Target: HER

Cat.No: T63881

EGFR/HER2-IN-5

Cat.No: T64254

Cat.No: T62487

Cat.No: T75165

Cat.No: T62271

Cat.No: T75164

Cat.No: T63432

Cat.No: T60896

EGFR/HER2/DHFR-IN-1

Cat.No: T61596

Cat.No: T63441

Cat.No: T64003

Cat.No: T60572

EGFR/HER2/TS-IN-1

Cat.No: T63401

EGFR/HER2/DHFR-IN-3

Cat.No: T82492

Target: EGFR

EGFR/HER2/CDK9-IN-1

Cat.No: T62746

EGFR/HER2/CDK9-IN-2

Cat.No: T63357

EGFR/HER2/CDK9-IN-3

Cat.No: T63161

EGFR/HER2-IN-2

Cat.No: T62776

EGFR/HER2-IN-3

Cat.No: T62777

EGFR/HER2-IN-9

Cat.No: T72854

EGFR/HER2-IN-4

Cat.No: T64253

EGFR/HER2-IN-7

Cat.No: T61272

EGFR/HER2/TS-IN-2

Cat.No: T63532

EGFR/HER2/DHFR-IN-2

Cat.No: T82493

Target: EGFR

Cat.No: T11917

Synonym: Lys-Nε-MCC-DM1

Target: Microtubule Associated

Cat.No: T9912

Target: EGFR

EGFR/HER2-IN-8

Cat.No: T60938

EGFR/HER2-IN-6

Cat.No: T61732

Cat.No: T6039

Synonym: TAK285,TAK 285

Target: EGFR, MEK, HER, Aurora Kinase

Cat.No: T11249L

Synonym: Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ

Target: Topoisomerase

Cat.No: T1785

Synonym: PD 0332991,帕博西尼,帕布昔利布

Target: CDK

Cat.No: T21312

Synonym: 阿法替尼,Afatinib free base,BIBW 2992

Target: EGFR, Autophagy

Palbociclib monohydrochloride

Cat.No: T6239

Synonym: PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl

Target: CDK

Palbociclib Isethionate

Cat.No: T6240

Synonym: Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐

Target: CDK

Afatinib Dimaleate

Cat.No: T1773

Synonym: 马来酸阿法替尼,双马来酸盐阿法替尼,BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate

Target: EGFR, HER, Autophagy

(S)-Sunvozertinib

Cat.No: T9304

Synonym: N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008

Target: EGFR, HER

Cat.No: T63643

Target: HER

Cat.No: T34760

Synonym: SYR-127063,BDBM 92454,SYR 127063,BDBM-92454,BDBM92454

Target: EGFR, HER

Cat.No: T6124

Synonym: 木利替尼,TAK-165

Target: EGFR, FGFR, JAK, PDGFR

Cat.No: T7819

Target: EGFR, HER

Cat.No: T9909

Synonym: 帕妥珠单抗,帕妥株单抗

Target: EGFR

Pyrotinib dimaleate

Cat.No: T12594

Synonym: SHR-1258 dimaleate

Target: EGFR, HER

BMS 599626 2HCl (873837-23-1(HCl))

Cat.No: T5398

Synonym: AC480 dihydrochloride

Target: HER

Cat.No: T9072

Synonym: BDTX-189

Target: EGFR, HER, BTK, RIP kinase

BMS-599626 Hydrochloride

Cat.No: T5390

Synonym: AC480 Hydrochloride

Target: HER

Cat.No: T69534

Synonym: BI 764532,BI 1810631

Target: Tyrosine Kinases, HER

Epertinib hydrochloride

Cat.No: T11213

Synonym: S-22611 hydrochloride

Target: EGFR, HER

Cat. No.	Product Name	Target	Signaling Pathways
T6290	Tanespimycin 坦螺旋霉素,17-AAG,CP 127374,NSC 330507,KOS 953	Apoptosis; Mitophagy; HSP; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Metabolism; Microbiology/Virology
	Tanespimycin (KOS 953) 是一种 Hsp90 抑制剂，可选择性抑制 BT474 肿瘤细胞 Hsp90，IC50为 5 nM。它消耗细胞内 STK38/NDR1，并降低 STK38 激酶活性，还能下调stk38基因表达。
T4S0544	Furanodienone 呋喃二烯酮,莪术呋喃二烯酮	Apoptosis; HER	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Furanodienone 是来源于姜黄根茎的一种主要生物活性成分，可诱导细胞凋亡。
T3673	Mollugin 大叶茜草素,Rubimaillin	HER; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。

天然产物

Cat.No: T6290

Synonym: 坦螺旋霉素,17-AAG,CP 127374,NSC 330507,KOS 953

Target: Apoptosis, Mitophagy, HSP, Antibacterial, Antibiotic, Autophagy

Cat.No: T4S0544

Synonym: 呋喃二烯酮,莪术呋喃二烯酮

Target: Apoptosis, HER

Cat.No: T3673

Synonym: 大叶茜草素,Rubimaillin

Target: HER, JAK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02314	HER2/ERBB2 Protein, Mouse, Recombinant (His) HER2,c-erbB2,erb-b2 rece...	Mouse	HEK293 Cells
	HER2/ERBB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is P70424.
TMPY-02469	HER2/ERBB2 Protein, Mouse, Recombinant (hFc) EGFR2,c-erbB2,l11Jus8,Erbb-2,mKIA...	Mouse	HEK293 Cells
	HER2/ERBB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.7 kDa and the accession number is P70424.
TMPY-00167	HER2/ERBB2 Protein, Human, Recombinant HER-2/neu,erb-b2 receptor tyrosin...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1.
TMPJ-00778	HER2/ERBB2 Protein, Human, Recombinant (His) TKR1,Metastatic lymph node gene 19 protein,ERBB2,Pr...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 90-120 KDa and the accession number is P04626.
TMPY-05239	HER2/ERBB2 Protein, Human, Recombinant , Biotinylated CD340,ENVW,ENV,HER2,HERV7Q,HE...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant , Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1.
TMPY-01137	HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His) erb-b2 receptor tyrosine kinase 2,NEU,ENVW...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1.
TMPY-04684	HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His) HERVWENV,MLN 19,HERV7Q,HERVW,CD34...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is P04626-1.
TMPY-04698	HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His) HERV-7q,TKR1,HERV7Q,ENV,HER-2...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is P04626-1.
TMPY-00636	HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) erb-b2 receptor tyrosine kinase 2,EGFR...	Cynomolgus	HEK293 Cells
	HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.8 kDa and the accession number is G7PUM4.
TMPY-01944	HER2/ERBB2 Protein, Rat, Recombinant (His) EGFR2,erb-b2 receptor tyrosine kinase ...	Rat	HEK293 Cells
	HER2/ERBB2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.2 kDa and the accession number is AAH61863.1.
TMPY-03719	HER2/ERBB2 Protein, Canine, Recombinant (His) erb-b2 receptor tyrosine kinase 2,EGFR...	Canine	HEK293 Cells
	HER2/ERBB2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.4 kDa and the accession number is A8WED5.
TMPK-00428	HER2/ErbB2 Protein, Human, Recombinant (His & Avi) MLN 19,HER2,HER-2,HE...	Human	HEK293 Cells
	ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane.
TMPK-00429	HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi) HERV7Q,HER-2,HER2	Human	HEK293 Cells
	HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 18.5 kDa and the accession number is P04626-1.
TMPK-00430	HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi), Biotinylated MLN19,HERV7Q,HERVW,MLN 19,TKR1,her	Human	HEK293 Cells
	HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 18.5 kDa and the accession number is P04626-1.
TMPY-00745	HER2/ERBB2 Protein, Human, Recombinant (hFc) NEU,CD340,HER-2/neu,HERV7Q,TKR1,e...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.1 kDa and the accession number is P04626-1.
TMPJ-00776	HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated Tyrosine kinase-type cell surface receptor HER2...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 120-140 KDa and the accession number is P04626.
TMPY-05368	HER2/ERBB2 Protein, Human, Recombinant (hFc), Biotinylated HERVW,ERVWE1,MLN 19,HERV-W-ENV,HER	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.1 kDa and the accession number is P04626-1.
TMPJ-00777	HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc) TKR1,Proto-oncogene Neu,EGFR2,Tyrosine kinase-type ...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-145 KDa and the accession number is P04626.
TMPY-06612	HER2/ERBB2 Protein, Human, Recombinant (mFc) HER2,MLN 19,erb-b2 receptor tyros...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 95.75 kDa and the accession number is NP_004439.2.
TMPY-05315	HER2/ERBB2 Protein, Human, Recombinant (His & Avi), Biotinylated ERVWE1,HER-2/neu,NEU,HERV-7q,erb-...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 72.6 kDa and the accession number is P04626-1.
TMPY-04538	HER2/ERBB2 Protein, Human, Recombinant (aa 676-1255, His & GST) TKR1,HERV-7q,ERVWE1,EGFR2,HERV7Q,...	Human	Baculovirus Insect Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 676-1255, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 92 kDa and the accession number is P04626-1.
TMPY-04955	HER2/ERBB2 Protein, Human, Recombinant (His), Amine-Labeled Biotinylated HER2,MLN 19,HERVW,NEU,ERVWE1,EGFR...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (His), Amine-Labeled Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1.
TMPY-05754	HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His), Amine-Labeled Biotinylated MLN19,HERV-7q,MLN 19,HER-2,ERVWE1...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His), Amine-Labeled Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is AAA75493.1.
TMPY-01945	HER2/ERBB2 Protein, Rhesus, Recombinant (hFc) EGFR2,erb-b2 receptor tyrosine kinase ...	Rhesus	HEK293 Cells
	HER2/ERBB2 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.3 kDa and the accession number is XP_001090430.1.
TMPY-01942	HER2/ERBB2 Protein, Rat, Recombinant erb-b2 receptor tyrosine kinase 2,EGFR...	Rat	HEK293 Cells
	HER2/ERBB2 Protein, Rat, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 70.6 kDa and the accession number is AAH61863.1.
TMPY-00465	HER2/ERBB2 Protein, Cynomolgus, Recombinant (hFc) erb-b2 receptor tyrosine kinase 2,EGFR...	Cynomolgus	HEK293 Cells
	HER2/ERBB2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.4 kDa.
TMPY-01943	HER2/ERBB2 Protein, Rat, Recombinant (hFc) erb-b2 receptor tyrosine kinase 2,EGFR...	Rat	HEK293 Cells
	HER2/ERBB2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 97 kDa and the accession number is AAH61863.1.
TMPY-01946	HER2/ERBB2 Protein, Rhesus, Recombinant (His) EGFR2,erb-b2 receptor tyrosine kinase ...	Rhesus	HEK293 Cells
	HER2/ERBB2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is XP_001090430.1.
TMPY-06856	HER2/ERBB2 Protein, Cynomolgus, Recombinant (His & Avi) erb-b2 receptor tyrosine kinase 2,EGFR...	Cynomolgus	HEK293 Cells
	HER2/ERBB2 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 72.63 kDa and the accession number is XP_001090430.1.
TMPJ-00791	HER2/ERBB2 Protein, Rat, Recombinant (E. coli, His) p185erbB2,Epidermal growth factor receptor-related ...	Rat	E. coli
	ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB...
TMPK-01019	EPHA5 Protein, Mouse, Recombinant (His) TYRO4,HEK7,EHK-1,EphA5,EK7,BSK,Rek7,EHK1,TYRO4HEK7CEK7	Mouse	HEK293 Cells
	The aim of the present study was to evaluate ephrin type-A receptor 5 (EphA5) expression and its clinicopathological significance in gastric cancer. Gastric cancer tissues were analyzed by immunohistochemistry. The association between EphA5 expression and clinicopathological parameters, human epidermal growth factor receptor 2 (HER2) status and Ki-67 proliferation index was statistically analyzed.
TMPY-03398	FHIT Protein, Human, Recombinant (His) FRA3B,AP3Aase,fragile histidine triad	Human	E. coli
	Fragile histidine triad, also known as FHIT, may play a key role in differentiating humans from apes. Fragile histidine triad gene belongs to the histidine triad gene family. It has been shown that fragile histidine triad synergizes with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. Fragile histidine triad gene works as a tumor suppressor as it has been demonstrated in animal studies. The exact molecular function of FHIT is still partially unclear. It als...
TMPY-04484	ACK1 Protein, Human, Recombinant (GST) ACK-1,ACK1,p21cdc42Hs,ACK,tyrosine kinase,...	Human	Baculovirus Insect Cells
	ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 mediates CDC42-dependent cell migration via phosphorylation of BCAR1. The ACK1 protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. ACK1 integrates signals from plethora of liga...

重组蛋白

HER2/ERBB2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02314

Species: Mouse

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02469

Species: Mouse

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant

Cat.No: TMPY-00167

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00778

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant , Biotinylated

Cat.No: TMPY-05239

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)

Cat.No: TMPY-01137

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His)

Cat.No: TMPY-04684

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His)

Cat.No: TMPY-04698

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-00636

Species: Cynomolgus

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-01944

Species: Rat

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Canine, Recombinant (His)

Cat.No: TMPY-03719

Species: Canine

Expression System: HEK293 Cells

HER2/ErbB2 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00428

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00429

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00430

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00745

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPJ-00776

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05368

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc)

Cat.No: TMPJ-00777

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-06612

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05315

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (aa 676-1255, His & GST)

Cat.No: TMPY-04538

Species: Human

Expression System: Baculovirus Insect Cells

HER2/ERBB2 Protein, Human, Recombinant (His), Amine-Labeled Biotinylated

Cat.No: TMPY-04955

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His), Amine-Labeled Biotinylated

Cat.No: TMPY-05754

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-01945

Species: Rhesus

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Rat, Recombinant

Cat.No: TMPY-01942

Species: Rat

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-00465

Species: Cynomolgus

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-01943

Species: Rat

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-01946

Species: Rhesus

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Cynomolgus, Recombinant (His & Avi)

Cat.No: TMPY-06856

Species: Cynomolgus

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPJ-00791

Species: Rat

Expression System: E. coli

EPHA5 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01019

Species: Mouse

Expression System: HEK293 Cells

FHIT Protein, Human, Recombinant (His)

Cat.No: TMPY-03398

Species: Human

Expression System: E. coli

ACK1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04484

Species: Human

Expression System: Baculovirus Insect Cells

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