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Anti-HER2/ERBB2 Antibody (2R301)
还可以产品编号 TMAH-00401
别名 TKR1, NGL, NEU, MLN19, MLN 19, HERVW, HERV7Q, herstatin, HER-2, HER2, ERVWE1, ERBB2, ENVW, ENV, EGFR2, CD340
Anti-HER2/ERBB2 Antibody (2R301) 是一种抗体，靶向 HER2/ERBB2。Anti-HER2/ERBB2 Antibody (2R301) 可用于 ELISA。
Anti-HER2/ERBB2 Antibody (2R301)
Anti-HER2/ERBB2 Antibody (2R301)
还可以产品编号 TMAH-00401 别名 TKR1, NGL, NEU, MLN19, MLN 19, HERVW, HERV7Q, herstatin, HER-2, HER2, ERVWE1, ERBB2, ENVW, ENV, EGFR2, CD340
Anti-HER2/ERBB2 Antibody (2R301) 是一种抗体，靶向 HER2/ERBB2。Anti-HER2/ERBB2 Antibody (2R301) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-HER2/ERBB2 Antibody (2R301) is an antibody targeting HER2/ERBB2. Anti-HER2/ERBB2 Antibody (2R301) can be used in ELISA. |
| 别名 | TKR1, NGL, NEU, MLN19, MLN 19, HERVW, HERV7Q, herstatin, HER-2, HER2, ERVWE1, ERBB2, ENVW, ENV, EGFR2, CD340 |
| Ig Type | Human IgG1 |
| 克隆号 | 2R301 |
| 交叉反应 | Human |
| 验证活性 | The Binding Activity of Human ERBB2 with Anti-ERBB2 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ERBB2 at 2 μg/mL can bind Anti-ERBB2 recombinant antibody, the EC50 is 2.455-3.565 ng/mL. |
| 应用 | ELISA |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Early endosome. Cytoplasm, perinuclear region. Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human ERBB2 Protein |
| 抗原种属 | Human |
| 基因ID | 2064 |
| Uniprot ID | |
| 研究领域 | Cancer, Tags & Cell Markers, Immunology, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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