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Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103)
还可以产品编号 TMAY-01653
Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103) 是一种 Rabbit 抗体，靶向 Phospho-HER2/ErbB2 (Tyr1221, 1222)。Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103) 可用于 WB。
Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103)
Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103)
还可以产品编号 TMAY-01653
Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103) 是一种 Rabbit 抗体，靶向 Phospho-HER2/ErbB2 (Tyr1221, 1222)。Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103) 可用于 WB。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103) is a Rabbit antibody targeting Phospho-HER2/ErbB2 (Tyr1221, 1222). Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103) can be used in WB. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 6Q103 |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of extracts from serum-starved SkBr3, untreated (-) or treated with EGF (200 ng/mL, 10 min; +), using Phospho-HER2/ErbB2 (Tyr1221, 1222) rabbit Monoclonal Antibody at 1:200000 dilution (upper) or Anti-Her2/ERBB2 Antibody, Mouse Monoclonal at 1:500 dilution (lower). 2. Western blot analysis of extracts from serum-starved SkBr3, untreated (line A); treated with EGF (200 ng/mL, 10 min), without peptide (line B) or antigen-specific phosphopeptide (line C) or antigen-specific peptide (line D) using Phospho-HER2/ErbB2 (Tyr1221, 1222) rabbit monoclonal Antibody at 1:200000 dilution. (Validation Experiment) 3. Western blot analysis of extracts from serum-starved SkBr3, untreated (line A); treated with EGF (200 ng/mL, 10 min) (line B); treated with EGF and λ-phosphatase (line C) using Phospho-HER2/ErbB2 (Tyr1221, 1222) rabbit monoclonal Antibody at 1:200000 dilution. (Validation Experiment) 4. Western blot analysis of extracts from serum-starved SkBr3, treated with EGF (200 ng/mL, 10 min), using Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody, Rabbit Mab and other brands’ antibodies (Company C) at dilution of 1:300000, 1:100000 and 1:10000. (Validation Experiment) |
| 应用 | WB |
| 推荐剂量 | WB: 1:10000-1:200000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around (Tyr1221, 1222) of human HER2/ErbB2. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| 研究背景 | Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic phosphopeptide corresponding to residues around (Tyr1221, 1222) of human HER2/ErbB2. |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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