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Anti-Phospho-HER2/ERBB2 (Thr 686) Antibody (1M462)
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产品编号 TMAC-01802
别名 p-HER2/ERBB2 (Thr 686), p-HER2/ERBB2 (T 686), HER2/ERBB2 (p-Thr 686), HER2/ERBB2 (p-T 686)
Anti-Phospho-HER2/ERBB2 (Thr 686) Antibody (1M462) 是一种 Mouse 抗体，靶向 Phospho-HER2/ERBB2 (Thr 686)。Anti-Phospho-HER2/ERBB2 (Thr 686) Antibody (1M462) 可用于 WB,IP。
Anti-Phospho-HER2/ERBB2 (Thr 686) Antibody (1M462)
Anti-Phospho-HER2/ERBB2 (Thr 686) Antibody (1M462)
还可以产品编号 TMAC-01802 别名 p-HER2/ERBB2 (Thr 686), p-HER2/ERBB2 (T 686), HER2/ERBB2 (p-Thr 686), HER2/ERBB2 (p-T 686)
Anti-Phospho-HER2/ERBB2 (Thr 686) Antibody (1M462) 是一种 Mouse 抗体，靶向 Phospho-HER2/ERBB2 (Thr 686)。Anti-Phospho-HER2/ERBB2 (Thr 686) Antibody (1M462) 可用于 WB,IP。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
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| 产品描述 | Anti-Phospho-HER2/ERBB2 (Thr 686) Antibody (1M462) is a Mouse antibody targeting Phospho-HER2/ERBB2 (Thr 686). Anti-Phospho-HER2/ERBB2 (Thr 686) Antibody (1M462) can be used in WB,IP. |
| 别名 | p-HER2/ERBB2 (Thr 686), p-HER2/ERBB2 (T 686), HER2/ERBB2 (p-Thr 686), HER2/ERBB2 (p-T 686) |
| 克隆号 | 1M462 |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of Neu phosphorylation in serum starved A431 (A), and serum starved A431 treated for 15 minutes with PMA (B), LPA (C), Ceramide (D), Bradykinin (E) and Bombesin (F) whole cell lysates. |
| 应用 | |
| 推荐剂量 | WB: 1:100-1000; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | PBS with < 0.1% sodium azide and 0.1% gelatin. |
| 研究背景 | Neu (ErbB-2 erythroblastic leukemia viral oncogene homolog 2, HER-2, NGL, TKR1, c-erb B2) oncogene was originally cloned from a rat neuroglioblastoma. Human Neu is referred to as HER-2 since the protein structure resembles human epidermal growth factor receptor (HER). ErbB-2 refers to a high level of similarity to ErbB (avian erythroblastosis oncogene B), later found to code for EGFR (HER). Tyr 1248-phosphorylated Neu localizes with Mucin 4/sialomucin complex at the apical surfaces of ductal and alveolar cells in rodent lactating gland. Phosphorylation of Neu at Tyr 1139 promotes association of GRB2 and GRB7 through an Src homology 2 (SH2) domain-dependent interaction and contributes to the etiology of certain breast, gastric and esophageal cancers and testicular germ cell tumors. Neu phosphorylation on Tyr 1221 and Tyr 1248 promotes association of Shc (SH2 domain-containing transforming protein 1) through an SH2 domain. Neu phosphorylation at Tyr 1196 and Tyr 1248 promotes association of Shc through a PTB (phosphotyrosine binding) domain. SH2 and PTB domains recognize tyrosine phosphorylated proteins in a sequence-specific fashion and transduce extracellular signals via subcellular targeting, directing assembly of complexes and modulating enzymatic activity. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Amino acid residues surrounding Threonine 686 of Neu of human origin |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Theoretical: 185 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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