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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-Her2/ERBB2 Antibody (2N22)

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货号 TMAY-00039

别名 erb-b2 receptor tyrosine kinase 2, EGFR2

Anti-Her2/ERBB2 Antibody (2N22) 是一种 Rabbit 抗体，靶向 Her2/ERBB2。Anti-Her2/ERBB2 Antibody (2N22) 可用于 ELISA,ICC/IF,IHC-P。

Anti-Her2/ERBB2 Antibody (2N22)

Anti-Her2/ERBB2 Antibody (2N22)

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货号 TMAY-00039 别名 erb-b2 receptor tyrosine kinase 2, EGFR2

Anti-Her2/ERBB2 Antibody (2N22) 是一种 Rabbit 抗体，靶向 Her2/ERBB2。Anti-Her2/ERBB2 Antibody (2N22) 可用于 ELISA,ICC/IF,IHC-P。

规格价格库存数量
20 μL
¥ 790
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Her2/ERBB2 Antibody (2N22) is a Rabbit antibody targeting Her2/ERBB2. Anti-Her2/ERBB2 Antibody (2N22) can be used in ELISA,ICC/IF,IHC-P.
别名erb-b2 receptor tyrosine kinase 2, EGFR2
Ig Type
Rabbit IgG
克隆号
2N22
反应种属
Human
特异性
Human Her2/ERBB2
Has cross-reactivity in ELISA with
Human HER2 / ErbB2 (Cytoplasmic Domain, 676-1255) (His & GST Tag)
Human HER2 / ErbB2 (ECD,1-652) (His Tag)
Human HER2 / ErbB2 (ECD, domain I) (His Tag)
Human HER2 / ErbB2 (ECD, domain IV) (His Tag)
Human ErbB1 / EGFR
Human ErbB3 / HER3
Human ErbB4 / HER4
验证活性
1. Immunofluorescence staining of Human ErbB2 in SKBR3 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Rabbit anti-Human ErbB2 monoclonal antibody (1:100) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody ( green ) and counterstained with DAPI ( blue ). Positive staining was localized to plasma membrane.
2. Immunochemical staining of human ERBB2 in human breast carcinoma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
应用ELISAICC/IFIHC-P
推荐剂量
ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500; ICC-IF: 1:50-1:1000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human ErbB2 / HER2 cytoplasmic domain (rhErbB2; TMPY-04538; NP_004439.2; Lys 676-Val 1255).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human ErbB2 protein (TMPY-04538)
抗原种属
Human
研究领域
Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs)
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.
存储-20°C for 1 year

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