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Anti-Her2/ERBB2 Antibody (6Y940)
还可以产品编号 TMAY-00034
Anti-Her2/ERBB2 Antibody (6Y940) 是一种 Mouse 抗体，靶向 Her2/ERBB2。Anti-Her2/ERBB2 Antibody (6Y940) 可用于 FCM,ICC/IF。
Anti-Her2/ERBB2 Antibody (6Y940)
Anti-Her2/ERBB2 Antibody (6Y940)
还可以产品编号 TMAY-00034
Anti-Her2/ERBB2 Antibody (6Y940) 是一种 Mouse 抗体，靶向 Her2/ERBB2。Anti-Her2/ERBB2 Antibody (6Y940) 可用于 FCM,ICC/IF。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Her2/ERBB2 Antibody (6Y940) is a Mouse antibody targeting Her2/ERBB2. Anti-Her2/ERBB2 Antibody (6Y940) can be used in FCM,ICC/IF. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6Y940 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunofluorescence staining of Human ERBB2 in MCF7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with mouse anti-Human ERBB2 monoclonal antibody (1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody(green). Positive staining was localized to cell membrane. 2. Flow cytometric analysis of anti-Human ErbB2 on MCF-7 cells. |
| 应用 | FCM,ICC/IF |
| 推荐剂量 | ICC-IF: 1:20-1:100; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human HER2 / ErbB2 (rh HER2 / ErbB2; TMPY-01137; NP_004439.2; Met1-Thr652). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0 |
| 研究背景 | Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human HER2 / ErbB2 protein (TMPY-01137) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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