C1A

C1A is an inhibitor of HDAC6 which modulates downstream autophagy substrates and leads to growth inhibition of a diverse set of cancer cell lines.

Benazoline oxalate salt is a pharmacological active compound that inhibits casein kinase Iε (CKIε) or CKIδ phosphorylation of the PER2 protein.

Gentamicin C1a，作为半合成抗生素Etimicin的前体，显示出抗菌活性，并且是Gentamicin复合物中的主要成分。

(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2 , γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1

Dc1a是一种从沙漠灌木蜘蛛Diguetia canities分离的毒素，有效促进德国小蠊Nav通道(BgNav1)的开放。

Propargyl-O-C1-amido-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-O-C1-amido (ERα ligand 1) forms a complex with the cIAP1 ligand Bestatin, leading to the creation of SNIPER[1].

Propargyl-O-C1-amido-PEG3-C2-NHS ester is a non-cleavable 3-unit polyethylene glycol (PEG) linker employed for the chemical synthesis of antibody-drug conjugates (ADCs).

Anti-CD47 (h4C1) 抗体可用于Block, ELISA, FC等相关的研究。

Anti-human mouse CD47 (VxP037-01LC1) 抗体可用于blocking等相关的研究。

Propargyl-O-C1-amido-PEG2-C2-NHS ester is a non-cleavable 2-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

DBCO-PEG3-C1-acid 作为一种抗体-药物偶联物 (ADC) 连接体，用作细菌促进的叠氮化物-炔烃点击化学反应中的反应手柄。

Nutlin-C1-amido-PEG4-C2-N3 is a novel compound that functions as a ligand-linker conjugate for the E3 ligase. It is a synthesized molecule incorporating the MDM2 ligand derived from Nutlin 3, and a 4-unit PEG linker. This compound is specifically designed for utilization in PROTAC technology.

Soluble epoxide hydrolase (sEH) PROTAC 1a是一种利用蛋白质降解靶向嵌合体(PROTAC)技术，通过连接区域将cereblon配体1与sEH抑制剂t-TUCB结合。该化合物通过促进sEH的降解，特异性抑制sEH的水解酶活性(IC50 = 0.8 nM)，相较于其磷酸酶活性(IC50 = >10,000 nM)具有较高选择性。sEH PROTAC 1a还特定促进细胞质中而非过氧体中的sEH降解，并通过溶酶体而非蛋白酶体实现其降解。它能够降低thapsigargin诱导的HepG2与293T细胞中磷酸化的inositol-requiring enzyme 1α (IRE1α)水平和X-box结合蛋白1 (XBP1)剪接，表明能减少ER应激。

Biotin-PEG2-C1-aldehyde is a polyethylene glycol (PEG)-based linker utilized in synthesizing proteolysis targeting chimeras (PROTACs) [1].

Azide-PEG3-C1-Ala is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bromoacetamide-PEG3-C1-acid is a PEG-based PROTAC linker utilized for PROTAC synthesis.