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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550)

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货号 TMAB-11306

Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) 是一种 Rabbit 抗体，靶向 Phospho-SMC1 alpha (Ser957)。Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550)

Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550)

一键复制产品信息
Rating icon 还可以
货号 TMAB-11306

Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) 是一种 Rabbit 抗体，靶向 Phospho-SMC1 alpha (Ser957)。Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) is a Rabbit antibody targeting Phospho-SMC1 alpha (Ser957). Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
克隆号
9G550
反应种属
Human
应用WBIHC-PIHC-FrICC/IFIF
推荐剂量
WB: 1:1000-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; ICC/IF: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus. Chromosome. Chromosome, centromere, kinetochore. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesion complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesion complexes remain. At anaphase, the RAD21 subunit of the cohesion complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesion complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis
组织特异性The disease is caused by mutations affecting the gene represented in this entry. Disease description:A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. Characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped.
抗原信息
免疫原
A synthesized peptide: human SMC1 alpha around the phosphorylation site of S957
抗原种属
Human
基因名称
SMC1A
基因ID
27127
蛋白名称
Structural maintenance of chromosomes protein 1A
Uniprot ID
Q14683
功能
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesion complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
化学信息
分子量Theoretical: 143 kDa. Actual: 160 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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