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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MUC1 Antibody (7P595)

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货号 TMAB-09090

Anti-MUC1 Antibody (7P595) 是一种 Rabbit 抗体，靶向 MUC1。Anti-MUC1 Antibody (7P595) 可用于 WB,IHC-P,ICC/IF,IP,FCM,IHC-Fr,IF。

Anti-MUC1 Antibody (7P595)

Anti-MUC1 Antibody (7P595)

一键复制产品信息
Rating icon 还可以
货号 TMAB-09090

Anti-MUC1 Antibody (7P595) 是一种 Rabbit 抗体，靶向 MUC1。Anti-MUC1 Antibody (7P595) 可用于 WB,IHC-P,ICC/IF,IP,FCM,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-MUC1 Antibody (7P595) is a Rabbit antibody targeting MUC1. Anti-MUC1 Antibody (7P595) can be used in WB,IHC-P,ICC/IF,IP,FCM,IHC-Fr,IF.
Ig Type
IgG
克隆号
7P595
反应种属
Human,Mouse,Rat
应用WBIHC-PICC/IFIPFCMIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; ICC/IF: 1:50-200; IP: 1:20-50; FCM: 1:50-100; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Secreted; Cell membrane. Cytoplasm. Nucleus. On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus and Apical cell membrane. Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.
组织特异性Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 is expressed in tumor cells only.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
浓度1mg/ml
研究背景MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.
抗原信息
免疫原
A synthesized peptide: human Mucin 1
抗原种属
Human
基因名称
MUC1
基因ID
4582
蛋白名称
Mucin-1
Uniprot ID
P15941
功能
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
化学信息
分子量Theoretical: 138 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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