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Anti-Phospho-SMC1A (Ser957) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-SMC1A (Ser957)。Anti-Phospho-SMC1A (Ser957) Polyclonal Antibody 可用于 WB,IHC。
Anti-Phospho-SMC1A (Ser957) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-SMC1A (Ser957)。Anti-Phospho-SMC1A (Ser957) Polyclonal Antibody 可用于 WB,IHC。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,485 | 5日内发货 | |
100 μL | ¥ 2,245 | 5日内发货 |
产品描述 | Anti-Phospho-SMC1A (Ser957) Polyclonal Antibody is a Rabbit antibody targeting Phospho-SMC1A (Ser957). Anti-Phospho-SMC1A (Ser957) Polyclonal Antibody can be used in WB,IHC. |
别名 | SMC1A (p-Ser957), SMC1A (p-S957), p-SMC1A (Ser957), p-SMC1A (S957) |
Ig Type | IgG |
交叉反应 | Human |
验证活性 | 1. Western blot analysis of extracts from 293 cells untreated or treated with UV using SMC1 (Phospho-Ser957) Antibody TMAC-03805. 2. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using SMC1 (Phospho-Ser957) Antibody TMAC-03805 (left) or the same antibody preincubated with blocking peptide (right). |
应用 | |
抗体种类 | Polyclonal |
宿主来源 | Rabbit |
构建方式 | Polyclonal Antibody |
纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
性状 | Liquid |
缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
研究背景 | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. |
偶联 | Unconjugated |
其他可选修饰符 | Phospho |
免疫原 | Peptide sequence around phosphorylation site of serine 957 (G-S-S(p)-Q-G) derived from Human SMC1 |
抗原种属 | human |
Uniprot ID |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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