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Anti-HDAC1 Antibody (6C472)
还可以产品编号 TMAH-00533
Anti-HDAC1 Antibody (6C472) 是一种抗体，靶向 HDAC1。Anti-HDAC1 Antibody (6C472) 可用于 ELISA, WB。
Anti-HDAC1 Antibody (6C472)
Anti-HDAC1 Antibody (6C472)
还可以产品编号 TMAH-00533
Anti-HDAC1 Antibody (6C472) 是一种抗体，靶向 HDAC1。Anti-HDAC1 Antibody (6C472) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,195 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-HDAC1 Antibody (6C472) is an antibody targeting HDAC1. Anti-HDAC1 Antibody (6C472) can be used in ELISA, WB. |
| Ig Type | Rabbit IgG |
| 克隆号 | 6C472 |
| 交叉反应 | Human |
| 验证活性 | Western Blot -Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, Jurkat whole cell lysate, HL60 whole cell lysate -All lanes: HDAC1 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 56 kDa -Observed band size: 60 kDa |
| 应用 | ELISA, WB |
| 推荐剂量 | WB:1:500-1:5000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human HDAC1 |
| 抗原种属 | Human |
| 基因ID | 3065 |
| Uniprot ID | |
| 研究领域 | Isotype/Loading Controls, Epigenetics and Nuclear Signaling, Cardiovascular, Stem cells |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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