Name: Anti-ASIC1 Antibody
Brand: TargetMol
SKU: T9901A-1268
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-ASIC1 Antibody is a humanized monoclonal antibody that binds specifically to the extracellular domain of acid-sensing ion channel 1 (ASIC1). This product blocks mediated cation currents (primarily sodium ions), effectively reducing neuronal hyperexcitability and acidotoxicity induced by tissue acidosis. It serves as an important pharmacological tool for researching chronic pain, ischemic stroke, and neurodegenerative diseases.
体外活性	在电生理和细胞实验中，Anti-ASIC1 Antibody表现出对人 ASIC1 胞外环的高结合亲和力，并能以浓度依赖性方式有效抑制转染的 HEK293 细胞或原代皮层神经元中由 pH 5.0 诱发的内向电流 [1]。
体内活性	在利用缺血性卒中（如大脑中动脉闭塞，MCAO）或炎症性疼痛的小鼠/大鼠模型进行的药理学研究中，系统或中枢给予Anti-ASIC1 Antibody导致梗死体积显著缩小，并通阻断酸毒性和神经元死亡显著缓解了痛相关行为，证实了其强效的神经保护和镇痛功效 [1][2]。
别名	抗ASIC1抗体
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P78348
靶点	ASIC1

储存&溶解度

存储

Anti-ASIC1 Antibody