Nrf2

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

Cat. No.	Product Name	CAS No.	Purity
T60487	DDO-7263 化合物DDO-7263	2254004-96-9	98%
T60487	DDO-7263 是一种 1,2,4-Oxadiazole 衍生物，通过与 Rpn6 结合上调 Nrf2，从而阻断 26S 蛋白酶体的组装和随后Nrf2 的泛素化降解。DDO-7263 是一种有效的Nrf2激活剂，能够激活 Nrf2-ARE 信号通路并发挥抗炎活性。
T30087	Antroquinonol 安卓奎诺尔	1010081-09-0	98%
T30087	Antroquinonol 是一种来源于 Antrodia camphorata 的泛醌衍生物，具有抗炎和抗癌活性。Antroquinonol 通过增强 Nrf2 信号通路降低氧化应激，抑制局灶节段性肾小球硬化小鼠的炎症和硬化。Antroquinonol 具有治疗非小细胞肺癌的潜力，可用于结肠癌的研究。
TN1058	Pelargonidin chloride 氯化天竺葵素	134-04-3	98%
TN1058	Pelargonidin chloride 是一种氧化氮自由基的清除剂，具有抗氧化作用。
T11251	Ezetimibe ketone 化合物 T11251	191330-56-0	98%
T11251	Ezetimibe, a compound known as a Niemann-Pick C1-like1 (NPC1L1) inhibitor and a potent Nrf2 activator, effectively inhibits cholesterol absorption. Additionally,...
TN4038	Eupatolide 泽兰内酯	6750-25-0	98%
TN4038	Eupatolide 是从 Inula japonica 的花中分离出来的，具有抗炎活性。 Eupatolide 可用于研究乳腺癌细胞对 TRAIL 的耐药性。
TN5278	Zederone 化合物 TN5278	7727-79-9	98%
TN5278	Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
TN1548	6"-O-Malonyldaidzin 6''-O-丙二酰基大豆苷	124590-31-4	98%
TN1548	Daidzin 6''-O-malonate 是一种丙二酰化异黄酮，存在于大豆种子中。它可能具有保护眼睛的作用。
TP2109	TAT 14 NRF2激活剂多肽	1362661-34-4	98%
TP2109	TAT-14 是由14 个氨基酸组成的多肽，是 Nrf2激活因子，表现出抗炎活性。它通过靶向 Nrf2 上 Keap1 的结合位点而非 Nrf2 mRNA 表达来提高 Nrf2 蛋白水平。
T15474	Hesperin 化合物 T15474	4430-35-7	98%
T15474	Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2.
TMA1570	Sappanone A 化合物 TMA1570	102067-84-5	98%
TMA1570	Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
TN4064	Flavoglaucin 化合物 TN4064	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TMA0237	Carlinoside 化合物 TMA0237	59952-97-5	98%
TMA0237	Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nuclea...
TN4160	Goniothalamin 化合物Goniothalamin	17303-67-2	98%
TN4160	Goniothalamin 在各种癌细胞系中诱导细胞凋亡并具有胃保护活性。
T9112	(-)-Perillaldehyde 紫苏醛	18031-40-8	98%
T9112	L-Perillaldehyde 是紫苏草精油的主要成分，吸入后经由嗅觉神经功能表现出抗抑郁功能。
TN2336	Rehmapicrogenin 地黄苦苷元	135447-39-1	98%
TN2336	Rehmapicrogenin 调节 Nrf2/ARE 信号通路。Nrf2/ARE 信号通路是氧化应激最重要的途径。
TN4420	Latifolin 化合物 TN4420	10154-42-4	98%
TN4420	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
T16352	NSC23925 化合物 T16352	858474-14-3	98%
T16352	NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
TN1670	Ganodermanondiol 灵芝酮二醇	107900-76-5	98%
TN1670	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
TN1151	Procyanidol B4 原花青素B4	29106-51-2	98%
TN1151	Procyanidin B4 reveals significant antioxidant activity
TN3726	Cudraflavone B 化合物 TN3726	19275-49-1	98%
TN3726	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...