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Search Results for " p50 "

Targets Recommended: Apoptosis Epigenetic Reader Domain Histone Methyltransferase

15

抑制剂 & 化合物

4

天然产物

1

化合物库

12

重组蛋白

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Cat. No.	Product Name
L3800	NF-κB 通路分子库		729 compounds
	729 个 NF-κB 信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

NF-κB 通路分子库

Cat.No: L3800

Compounds: 729

Cat. No.	Product Name	Target	Signaling Pathways
T13336	VTP50469	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	VTP50469 是一种高选择性和口服活性的Menin-MLL 相互作用抑制剂，具有有效的抗白血病活性，Ki 为 104 pM。
T24584	P505-15 Acetate PRT 062607 Acetate,P505 15 Acetate,PRT-062607 Acetate,PRT062607 Acetate,P50515 Acetate	Tyrosinase	Proteases/Proteasome
	P505-15 Acetate 是脾脏酪氨酸激酶的选择性抑制剂，通过抑制白细胞免疫功能和炎症起作用，导致关节炎评分降低和组织学损伤减轻。
T80132	CBP501 Affinity Peptide
	CBP501 Affinity Peptide为Chk激酶抑制剂，具有消除DNA损伤剂诱导的G2停滞作用，主要应用于癌症研究领域。
TP2164	TP508 TFA (121341-81-9 free base) TP508 TFA	Others	Others
	TP508 TFA is a nonproteolytic thrombin peptide. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates the production of NO in human endothelial cells. It activates endothelial cells and stem cells to revascularize and regenerates tissues.
TP1853	TP508
	TP508 is a 23 amino acid synthetic peptide representing residues 508-530 of human prothrombin which is identified as a potential receptor-binding domain based on competition for high-affinity thrombin binding to fibroblasts.TP508 (Chrysalin) is an investi
T62657	SHP504
	SHP504 是一种 SHP2 磷酸酶的抑制剂，能够作用于 SHP21–525 (IC50: 21 μM)。
T69846	VTP50469 mesylate
	VTP-50469 is a novel, potent, selective, orally-available MeninMLL1 inhibitor, being effectively against MLL-rearranged and NPM1c+ leukemia, selectively killing cell lines with MLLrearrangements and NPM1c+ mutations.
T24736	RP5063 Hydrochloride RP-5063 HCl,RP 5063 HCl,RP 5063 Hydrochloride,RP-5063 Hydrochloride,RP5063 HCl
	RP5063 Hydrochloride is a modulator of multimodal serotonin receptors.
T13336L	VTP50469 fumarate	Others	Others
	VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.
T75763	TP508 TFA
	TP508 TFA为含23个氨基酸的非蛋白质水解凝血酶肽, 属凝血酶分子受体结合结构域部分。该化合物能激活内皮NO synthase(eNOS)，促进人内皮细胞内NO生成，进而通过激活内皮细胞及干细胞，促进血管及组织再生。
T69091	CBP501
	CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle.
T72785	PRMT5:MEP50 PPI
	PRMT5:MEP50 PPI是一款新型的抑制剂，专门针对PRMT5:MEP50蛋白-蛋白相互作用，展现了抗肿瘤活性，并对肺癌及前列腺癌细胞具有显著的抗增殖效果。
T78846	EP12	Apoptosis	Apoptosis
	EP12是一种c-Myc抑制剂及c-MycG4稳定剂，能够诱导多发性骨髓瘤细胞的细胞凋亡(apoptosis)及DNA损伤，并通过干扰NF-κB信号通路破坏P65/P50的核转位，从而抑制多发性骨髓瘤的生长。
T38153	NF-κB Inhibitor (trifluoroacetate salt)
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5
T37559	NF-κB Control
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α. NF-κB control is a peptide that is identical in sequence to NF-κB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids...

化合物

Cat.No: T13336

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

P505-15 Acetate

Cat.No: T24584

Synonym: PRT 062607 Acetate,P505 15 Acetate,PRT-062607 Acetate,PRT062607 Acetate,P50515 Acetate

Target: Tyrosinase

CBP501 Affinity Peptide

Cat.No: T80132

TP508 TFA (121341-81-9 free base)

Cat.No: TP2164

Synonym: TP508 TFA

Target: Others

Cat.No: TP1853

Cat.No: T62657

VTP50469 mesylate

Cat.No: T69846

RP5063 Hydrochloride

Cat.No: T24736

Synonym: RP-5063 HCl,RP 5063 HCl,RP 5063 Hydrochloride,RP-5063 Hydrochloride,RP5063 HCl

VTP50469 fumarate

Cat.No: T13336L

Target: Others

Cat.No: T75763

Cat.No: T69091

PRMT5:MEP50 PPI

Cat.No: T72785

Cat.No: T78846

Target: Apoptosis

NF-κB Inhibitor (trifluoroacetate salt)

Cat.No: T38153

Cat.No: T37559

Cat. No.	Product Name	Target	Signaling Pathways
TWS1977	Kamebakaurin 尾叶香茶菜丙素,Kamebakaurine	NF-κB	NF-κB
	Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物，是一种NF-κB 的抑制剂，能够抑制 p50 的 DNA 结合活性。
T3012	Mangiferin Alpizarin,Chinomin,芒果,Hedysarid	Apoptosis; Others; NF-κB; Nrf2	Apoptosis; Immunology/Inflammation; NF-κB; Others
	Mangiferin (Hedysarid) 是一种Nrf2激活剂。它抑制NF-κB 亚基p65和p50的核移位，具有抗氧化、抗糖尿病、抗高尿酸血症、抗病毒、抗癌和抗炎活性。
TN3922	Effusanin E	PARP; NF-κB; Caspase; COX; Antifection	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p65 proteins to down-regulate COX-2 expression .
TN4635	Neoechinulin A	NADPH-oxidase; Beta Amyloid; ASK; IκB/IKK; p38 MAPK; TNF; NOS; NF-κB; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regu

天然产物

Cat.No: TWS1977

Synonym: 尾叶香茶菜丙素,Kamebakaurine

Target: NF-κB

Cat.No: T3012

Synonym: Alpizarin,Chinomin,芒果,Hedysarid

Target: Apoptosis, Others, NF-κB, Nrf2

Cat.No: TN3922

Target: PARP, NF-κB, Caspase, COX, Antifection

Cat.No: TN4635

Target: NADPH-oxidase, Beta Amyloid, ASK, IκB/IKK, p38 MAPK, TNF, NOS, NF-κB, COX, Prostaglandin Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01181	CD40 Protein, Human, Recombinant (His) CDW40,CD40 molecule, TNF receptor superfamily member 5,TNFRS...	Human	HEK293 Cells
	CD40 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.7 kDa and the accession number is A0A0S2Z3C7.
TMPY-05957	CD40 Protein, Mouse, Recombinant (His) Bp50,HIGM1,TRAP,T-BAM,GP39,AI326936,p50,IG...	Mouse	HEK293 Cells
	CD40 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.81 kDa and the accession number is P27512-1.
TMPY-03558	CDC37 Protein, Mouse, Recombinant p50Cdc37,cell division cycle 37,p50	Mouse	Baculovirus Insect Cells
	CDC37 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 44.7 kDa and the accession number is Q61081.
TMPY-03534	CDC37 Protein, Mouse, Recombinant (His & GST) cell division cycle 37,p50,p50Cdc37	Mouse	Baculovirus Insect Cells
	CDC37 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 72.4 kDa and the accession number is Q61081.
TMPY-05599	CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated TNFRSF5,Bp50,CD40 molecule, TNF receptor superfamil...	Human	HEK293 Cells
	CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 47.7 kDa and the accession number is A0A0S2Z3C7.
TMPY-05614	CD40 Protein, Human, Recombinant (His & Avi), Biotinylated Bp50,p50,CDW40,CD40 molecule, TNF receptor...	Human	HEK293 Cells
	CD40 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 22.4 kDa and the accession number is A0A0S2Z3C7.
TMPY-00482	CD40 Protein, Human, Recombinant (hFc) CDW40,TNFRSF5,CD40 molecule, TNF receptor superfamily member...	Human	HEK293 Cells
	CD40 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is A0A0S2Z3C7.
TMPY-05359	CD40 Protein, Human, Recombinant (mFc) Bp50,TNFRSF5,CDW40,p50,CD40 molecule, TNF ...	Human	HEK293 Cells
	CD40 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45.5 kDa and the accession number is NP_001309350.1.
TMPY-05425	CD40 Protein, Mouse, Recombinant (hFc) IGM,AI326936,TRAP,T-BAM,p50,IMD3,Tnfrsf5,HIGM1,GP39...	Mouse	HEK293 Cells
	CD40 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is P27512-1.
TMPY-06024	CD40 Protein, Mouse, Recombinant (His & Avi), Biotinylated T-BAM,CD40 molecule, TNF receptor superfamily member 5,IGM,T...	Mouse	HEK293 Cells
	CD40 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 22.5 kDa and the accession number is P27512-1.
TMPY-04994	CD40 Protein, Mouse, Recombinant (rFc) HIGM1,IGM,IMD3,p50,GP39,T-BAM,Bp50,Tnfrsf5...	Mouse	HEK293 Cells
	CD40 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 45.4 kDa and the accession number is P27512-1.
TMPY-02387	NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST) NFKB3,p65,v-rel avian reticuloendotheliosis viral oncogene h...	Human	E. coli
	RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an eff...

重组蛋白

CD40 Protein, Human, Recombinant (His)

Cat.No: TMPY-01181

Species: Human

Expression System: HEK293 Cells

CD40 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05957

Species: Mouse

Expression System: HEK293 Cells

CDC37 Protein, Mouse, Recombinant

Cat.No: TMPY-03558

Species: Mouse

Expression System: Baculovirus Insect Cells

CDC37 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-03534

Species: Mouse

Expression System: Baculovirus Insect Cells

CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-05599

Species: Human

Expression System: HEK293 Cells

CD40 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05614

Species: Human

Expression System: HEK293 Cells

CD40 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00482

Species: Human

Expression System: HEK293 Cells

CD40 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05359

Species: Human

Expression System: HEK293 Cells

CD40 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-05425

Species: Mouse

Expression System: HEK293 Cells

CD40 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06024

Species: Mouse

Expression System: HEK293 Cells

CD40 Protein, Mouse, Recombinant (rFc)

Cat.No: TMPY-04994

Species: Mouse

Expression System: HEK293 Cells

NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST)

Cat.No: TMPY-02387

Species: Human

Expression System: E. coli

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