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Anti-Melan A Antibody (8P504) 是一种 Rabbit 抗体,靶向 Melan A。Anti-Melan A Antibody (8P504) 可用于 WB,IHC-P,FCM,IHC-Fr,IF,ICC/IF。
Anti-Melan A Antibody (8P504) 是一种 Rabbit 抗体,靶向 Melan A。Anti-Melan A Antibody (8P504) 可用于 WB,IHC-P,FCM,IHC-Fr,IF,ICC/IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,390 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
| 产品描述 | Anti-Melan A Antibody (8P504) is a Rabbit antibody targeting Melan A. Anti-Melan A Antibody (8P504) can be used in WB,IHC-P,FCM,IHC-Fr,IF,ICC/IF. |
| Ig Type | IgG |
| 克隆号 | 8P504 |
| 反应种属 | Human |
| 应用 | WBIHC-PFCMIHC-FrIFICC/IF |
| 推荐剂量 | WB: 1:500-2000; IHC-P: 1:50-200; FCM: 1:50-100; IHC-Fr: 1:50-200; IF: 1:50-200; ICC/IF: 1:50-200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation. |
| 组织特异性 | Expression is restricted to melanoma and melanocyte cell lines and retina. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | Melan A, a product of the MART-1 gene, is a melanocyte differentiation marker recognized by autologous cytotoxic T lymphocytes. Other melanoma-associated markers recognized by autologous cytotoxic T cells are reported to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1 and GAGE-1. The analysis of these different molecules and their expression in individual melanomas may be of help in the study of their particular molecular roles in melanocyte differentiation and tumorigenesis. |
| 免疫原 | A synthesized peptide: human MART1 |
| 抗原种属 | Human |
| 基因名称 | MLANA |
| 基因ID | |
| 蛋白名称 | Melanoma antigen recognized by T-cells 1 |
| Uniprot ID | |
| 功能 | Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. |
| 分子量 | Theoretical: 13 kDa. |
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
| 存储 | store at low temperature | -20°C for 1 year |